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Alcoholism is a devastating condition that represents a progression from initial alcohol use to dependence. Although most… Expand BACKGROUND
Depression and anxiety disorders have been linked to dysfunction of the hypothalamo-pituitary-adrenal (HPA) axis and… Expand Arginine-vasopressin is a hormone that plays an important part in circulatory and water homoeostasis. The three arginine… Expand There is a growing interest in the potential anxiolytic- and antidepressant-like effects of compounds that target neurokinin… Expand Vasopressin (AVP) and corticotropin-releasing factor (CRF) are key mediators in the organism's neuro-adaptive response to stress… Expand Arginine vasopressin (AVP) has been implicated in a variety of physiological and behavioral responses to stress. Synthesis of… Expand Repeated exposure to stress is known to induce structural remodelling and reduction of neurogenesis in the dentate gyrus… Expand The complexity of the stress response would appear to provide multiple opportunities for intervention, but treatment strategies… Expand The limbic localization of the arginine vasopressin V1b receptor has prompted speculation as to a potential role of this receptor… Expand (2S,4R)-1-[5-Chloro-1-[(2,4-dimethoxyphenyl)sulfonyl]-3-(2-methoxy-phenyl)-2-oxo-2,3-dihydro-1H-indol-3-yl]-4-hydroxy-N,N… Expand