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SSR 149415

Known as: SSR-149415, SSR149415 
National Institutes of Health

Papers overview

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Review
2006
Review
2006
An overview of SSR149415, a selective nonpeptide vasopressin V(1b) receptor antagonist for the treatment of stress-related disorders.
Vasopressin (AVP) and corticotropin-releasing factor (CRF) are key mediators in the organism's neuro-adaptive response to stress… 
Highly Cited
2006
Highly Cited
2006
Differential roles of amygdaloid nuclei in the anxiolytic- and antidepressant-like effects of the V1b receptor antagonist, SSR149415, in rats
RationaleSSR149415 ((2S, 4R)-1-[5-chloro-1-[(2,4-dimethoxyphenyl)sulfonyl]-3-(2-methoxyphenyl)-2-oxo-2,3-dihydro-1H-indol-3-yl]-4… 
Highly Cited
2006
Highly Cited
2006
Selective blockade of NK2 or NK3 receptors produces anxiolytic- and antidepressant-like effects in gerbils
Highly Cited
2005
Highly Cited
2005
AVP V1b selective antagonist SSR149415 blocks aggressive behaviors in hamsters
Highly Cited
2005
Highly Cited
2005
Mechanisms of Cell-surface Rerouting of an Endoplasmic Reticulum-retained Mutant of the Vasopressin V1b/V3 Receptor by a Pharmacological Chaperone*
Cell-surface expression and biological functions of several intracellular-retained G protein-coupled receptors are restored by… 
Highly Cited
2005
Highly Cited
2005
Evidence that the Lateral Septum is Involved in the Antidepressant-Like Effects of the Vasopressin V1b Receptor Antagonist, SSR149415
Previous experiments with the first selective nonpeptide vasopressin V1b receptor antagonist SSR149415 ((2S, 4R)-1-[5-chloro-1… 
Highly Cited
2005
Highly Cited
2005
Separation-induced ultrasonic vocalization in rat pups: Further pharmacological characterization
Highly Cited
2002
Highly Cited
2002
Anxiolytic- and antidepressant-like effects of the non-peptide vasopressin V1b receptor antagonist, SSR149415, suggest an innovative approach for the treatment of stress-related disorders
The limbic localization of the arginine vasopressin V1b receptor has prompted speculation as to a potential role of this receptor… 
Highly Cited
2002
Highly Cited
2002
Characterization of (2S,4R)-1-[5-chloro-1-[(2,4-dimethoxyphenyl)sulfonyl]-3-(2-methoxy-phenyl)-2-oxo-2,3-dihydro-1H-indol-3-yl]-4-hydroxy-N,N-dimethyl-2-pyrrolidine carboxamide (SSR149415), a…
(2S,4R)-1-[5-Chloro-1-[(2,4-dimethoxyphenyl)sulfonyl]-3-(2-methoxy-phenyl)-2-oxo-2,3-dihydro-1H-indol-3-yl]-4-hydroxy-N,N… 
Review
2002
Review
2002
Nonpeptide vasopressin receptor antagonists: development of selective and orally active V1a, V2 and V1b receptor ligands.
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