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SR 49059

Known as: SR-49059, SR49059 
National Institutes of Health

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1 relation

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relcovaptan

Papers overview

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Highly Cited
2014
Highly Cited
2014
Neuroanatomical distribution of oxytocin and vasopressin 1a receptors in the socially monogamous coppery titi monkey (Callicebus cupreus)
Highly Cited
2013
Highly Cited
2013
Regulation of bone remodeling by vasopressin explains the bone loss in hyponatremia
Significance In this study, we show that a primitive brain hormone, arginine vasopressin (AVP), which has hitherto been… 
Highly Cited
2013
Highly Cited
2013
Mice Heterozygous for the Oxytocin Receptor Gene (Oxtr+/−) Show Impaired Social Behaviour but not Increased Aggression or Cognitive Inflexibility: Evidence of a Selective Haploinsufficiency Gene…
We characterised the behavioural phenotype of mice heterozygous (Oxtr+/−) for the oxytocin receptor gene (Oxtr) and compared it… 
Highly Cited
2007
Highly Cited
2007
Functional rescue of vasopressin V2 receptor mutants in MDCK cells by pharmacochaperones: relevance to therapy of nephrogenic diabetes insipidus.
Intracellular retention of a functional vasopressin V2 receptor (V2R) is a major cause of congenital nephrogenic diabetes… 
Highly Cited
2005
Highly Cited
2005
Pharmacologic chaperones as a potential treatment for X-linked nephrogenic diabetes insipidus.
In many mendelian diseases, some mutations result in the synthesis of misfolded proteins that cannot reach a transport-competent… 
Highly Cited
2004
Highly Cited
2004
Pharmacochaperones Post-translationally Enhance Cell Surface Expression by Increasing Conformational Stability of Wild-type and Mutant Vasopressin V2 Receptors*
Some membrane-permeable antagonists restore cell surface expression of misfolded receptors retained in the endoplasmic reticulum… 
Highly Cited
2004
Highly Cited
2004
Functional rescue of the constitutively internalized V2 vasopressin receptor mutant R137H by the pharmacological chaperone action of SR49059.
In most cases, nephrogenic diabetes insipidus results from mutations in the V2 vasopressin receptor (V2R) gene that cause… 
Highly Cited
2004
Highly Cited
2004
Oxytocin- and vasopressin-induced growth of human small-cell lung cancer is mediated by the mitogen-activated protein kinase pathway.
Malignant growth of small-cell lung carcinoma is promoted by various neuroendocrine autocrine/paracrine loops. Therefore, to… 
Highly Cited
2002
Highly Cited
2002
Effects of Nonpeptide V1 Vasopressin Receptor Antagonist SR-49059 on Infarction Volume and Recovery of Function in a Focal Embolic Stroke Model
Background and Purpose— Cerebral edema develops very early after the onset of focal cerebral ischemia and may be a major factor… 
Highly Cited
1993
Highly Cited
1993
Biochemical and pharmacological properties of SR 49059, a new, potent, nonpeptide antagonist of rat and human vasopressin V1a receptors.
SR 49059, a new potent and selective orally active, nonpeptide vasopressin (AVP) antagonist has been characterized in several in… 
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