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SR 49059
Known as:
SR-49059
, SR49059
National Institutes of Health
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Papers overview
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Highly Cited
2014
Highly Cited
2014
Neuroanatomical distribution of oxytocin and vasopressin 1a receptors in the socially monogamous coppery titi monkey (Callicebus cupreus)
S. M. Freeman
,
H. Walum
,
+4 authors
L. Young
Neuroscience
2014
Corpus ID: 3754229
Highly Cited
2013
Highly Cited
2013
Regulation of bone remodeling by vasopressin explains the bone loss in hyponatremia
R. Tamma
,
Li Sun
,
+12 authors
M. Zaidi
Proceedings of the National Academy of Sciences
2013
Corpus ID: 6823099
Significance In this study, we show that a primitive brain hormone, arginine vasopressin (AVP), which has hitherto been…
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Highly Cited
2013
Highly Cited
2013
Mice Heterozygous for the Oxytocin Receptor Gene (Oxtr+/−) Show Impaired Social Behaviour but not Increased Aggression or Cognitive Inflexibility: Evidence of a Selective Haploinsufficiency Gene…
M. Sala
,
D. Braida
,
+7 authors
B. Chini
Journal of neuroendocrinology
2013
Corpus ID: 21642173
We characterised the behavioural phenotype of mice heterozygous (Oxtr+/−) for the oxytocin receptor gene (Oxtr) and compared it…
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Highly Cited
2007
Highly Cited
2007
Functional rescue of vasopressin V2 receptor mutants in MDCK cells by pharmacochaperones: relevance to therapy of nephrogenic diabetes insipidus.
J. Robben
,
M. Sze
,
N. Knoers
,
P. Deen
AJP - Renal Physiology
2007
Corpus ID: 16970
Intracellular retention of a functional vasopressin V2 receptor (V2R) is a major cause of congenital nephrogenic diabetes…
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Highly Cited
2005
Highly Cited
2005
Pharmacologic chaperones as a potential treatment for X-linked nephrogenic diabetes insipidus.
V. Bernier
,
J. Morello
,
+8 authors
D. Bichet
Journal of the American Society of Nephrology
2005
Corpus ID: 23162171
In many mendelian diseases, some mutations result in the synthesis of misfolded proteins that cannot reach a transport-competent…
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Highly Cited
2004
Highly Cited
2004
Pharmacochaperones Post-translationally Enhance Cell Surface Expression by Increasing Conformational Stability of Wild-type and Mutant Vasopressin V2 Receptors*
S. Wüller
,
B. Wiesner
,
+7 authors
A. Oksche
Journal of Biological Chemistry
2004
Corpus ID: 1647978
Some membrane-permeable antagonists restore cell surface expression of misfolded receptors retained in the endoplasmic reticulum…
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Highly Cited
2004
Highly Cited
2004
Functional rescue of the constitutively internalized V2 vasopressin receptor mutant R137H by the pharmacological chaperone action of SR49059.
V. Bernier
,
M. Lagacé
,
M. Lonergan
,
M. Arthus
,
D. Bichet
,
M. Bouvier
Molecular Endocrinology
2004
Corpus ID: 29847478
In most cases, nephrogenic diabetes insipidus results from mutations in the V2 vasopressin receptor (V2R) gene that cause…
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Highly Cited
2004
Highly Cited
2004
Oxytocin- and vasopressin-induced growth of human small-cell lung cancer is mediated by the mitogen-activated protein kinase pathway.
C. Péqueux
,
B. Keegan
,
M. Hagelstein
,
V. Geenen
,
J. Legros
,
W. North
Endocrine-Related Cancer
2004
Corpus ID: 30897847
Malignant growth of small-cell lung carcinoma is promoted by various neuroendocrine autocrine/paracrine loops. Therefore, to…
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Highly Cited
2002
Highly Cited
2002
Effects of Nonpeptide V1 Vasopressin Receptor Antagonist SR-49059 on Infarction Volume and Recovery of Function in a Focal Embolic Stroke Model
A. Shuaib
,
Chen Xu Wang
,
Tao Yang
,
Raza Noor
Stroke
2002
Corpus ID: 709128
Background and Purpose— Cerebral edema develops very early after the onset of focal cerebral ischemia and may be a major factor…
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Highly Cited
1993
Highly Cited
1993
Biochemical and pharmacological properties of SR 49059, a new, potent, nonpeptide antagonist of rat and human vasopressin V1a receptors.
C. Serradeil-Le Gal
,
J. Wagnon
,
+7 authors
G. Le Fur
Journal of Clinical Investigation
1993
Corpus ID: 24285323
SR 49059, a new potent and selective orally active, nonpeptide vasopressin (AVP) antagonist has been characterized in several in…
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