FAQ

SPT5 transcriptional elongation factor

Known as: SPT5 Protein, hSPT5, DSIF Large Subunit 
Transcription elongation factor SPT5 (1087 aa, ~121 kDa) is encoded by the human SUPT5H gene. This protein plays a role in both transcriptional… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1996-2015
01219962015

Related topics

Related topics

13 relations
Chromatin Remodeling FactorGenes, RegulatorNucleoplasmProtein Complex Subunit
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Broader (2)

Chromosomal Proteins, Non-HistoneTranscriptional Elongation Factors

Related mentions per year

Related mentions per year

1939-2018
19401960198020002020
SPT5 transcriptional elongation factor
Genes, Regulator
RNA Processing
Transcriptional Regulation
chromatin remodeling
Nucleoplasm

Papers overview

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2016
2016
SLEEP. Measuring the passage of brain time.
sciencemag.org SCIENCE G R A P H IC : V . A L T O U N IA N / S C IE N C E ner SUPT5H (homolog of Spt5), or both, reduced C9orf72… (More)
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2015
2015
Suppressor of Ty homolog-5, a novel tumor-specific human telomerase reverse transcriptase promoter-binding protein and activator in colon cancer cells.
The human telomerase reverse transcriptase (hTERT) promoter promotes differential hTERT gene expression in tumor cells and normal… (More)
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2012
2012
Mutations in the Transcription Elongation Factor SPT5 Disrupt a Reporter for Dosage Compensation in Drosophila
In Drosophila, the MSL (Male Specific Lethal) complex up regulates transcription of active genes on the single male X-chromosome… (More)
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Review
2009
Review
2009
Insights into the function of the human P-TEFb component CDK9 in the regulation of chromatin modifications and co-transcriptional mRNA processing.
Cyclin-dependent kinase-9 (CDK9) was originally characterized as a transcription elongation factor which regulates RNA Polymerase… (More)
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2001
2001
Positive transcription elongation factor B phosphorylates hSPT5 and RNA polymerase II carboxyl-terminal domain independently of cyclin-dependent kinase-activating kinase.
The CDK9-cyclin T kinase complex, positive transcription elongation factor b (P-TEFb), stimulates the process of elongation of… (More)
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Highly Cited
1999
Highly Cited
1999
Transcription elongation factor hSPT5 stimulates mRNA capping.
RNA polymerase II nascent transcripts are capped during pausing before elongation. Here we report that hSPT5, the human homolog… (More)
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1999
1999
Structure and function of the human transcription elongation factor DSIF.
5,6-Dichloro-1-beta-D-ribofuranosylbenzimidazole (DRB) is a classic inhibitor of transcription elongation by RNA polymerase II… (More)
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1999
1999
Tat-SF1 protein associates with RAP30 and human SPT5 proteins.
The potent transactivator Tat recognizes the transactivation response RNA element (TAR) of human immunodeficiency virus type 1… (More)
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Highly Cited
1998
Highly Cited
1998
DSIF, a novel transcription elongation factor that regulates RNA polymerase II processivity, is composed of human Spt4 and Spt5 homologs.
We report the identification of a transcription elongation factor from HeLa cell nuclear extracts that causes pausing of RNA… (More)
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1996
1996
Isolation, sequencing, and mapping of the human homologue of the yeast transcription factor, SPT5.
We isolated the human homologue, SUPT5H, of the yeast transcription factor, SPT5. The human homologue is 1088 aa long compared to… (More)
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