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SPT5 transcriptional elongation factor

Known as: SPT5 Protein, hSPT5, DSIF Large Subunit 
Transcription elongation factor SPT5 (1087 aa, ~121 kDa) is encoded by the human SUPT5H gene. This protein plays a role in both transcriptional… Expand
National Institutes of Health

Related topics

Related topics

13 relations
Chromatin Remodeling FactorGenes, RegulatorNucleoplasmProtein Complex Subunit
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Broader (2)

Chromosomal Proteins, Non-HistoneTranscriptional Elongation Factors

Papers overview

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2018
2018
Repeat-associated non-ATG (RAN) translation
Microsatellite expansions cause more than 40 neurological disorders, including Huntington's disease, myotonic dystrophy, and… Expand
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2018
2018
6th KOW domain of human hSpt5
 
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2015
2015
Suppressor of Ty homolog-5, a novel tumor-specific human telomerase reverse transcriptase promoter-binding protein and activator in colon cancer cells
The human telomerase reverse transcriptase (hTERT) promoter promotes differential hTERT gene expression in tumor cells and normal… Expand
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Highly Cited
2001
Highly Cited
2001
Positive transcription elongation factor B phosphorylates hSPT5 and RNA polymerase II carboxyl-terminal domain independently of cyclin-dependent kinase-activating kinase.
The CDK9-cyclin T kinase complex, positive transcription elongation factor b (P-TEFb), stimulates the process of elongation of… Expand
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2001
2001
The peptidyl-prolyl isomerase Pin1 interacts with hSpt5 phosphorylated by Cdk9.
We identify and characterize several phosphorylated forms of the hSpt5 subunit of the DRB sensitivity-inducing factor (DSIF). A… Expand
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Highly Cited
1999
Highly Cited
1999
Transcription elongation factor hSPT5 stimulates mRNA capping.
RNA polymerase II nascent transcripts are capped during pausing before elongation. Here we report that hSPT5, the human homolog… Expand
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1999
1999
Tat-SF1 protein associates with RAP30 and human SPT5 proteins.
The potent transactivator Tat recognizes the transactivation response RNA element (TAR) of human immunodeficiency virus type 1… Expand
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1999
1999
Tat-SF 1 Protein Associates with RAP 30 and Human SPT 5 Proteins
The potent transactivator Tat recognizes the transactivation response RNA element (TAR) of human immunodeficiency virus type 1… Expand
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Highly Cited
1998
Highly Cited
1998
DSIF, a novel transcription elongation factor that regulates RNA polymerase II processivity, is composed of human Spt4 and Spt5 homologs.
We report the identification of a transcription elongation factor from HeLa cell nuclear extracts that causes pausing of RNA… Expand
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1996
1996
Isolation, sequencing, and mapping of the human homologue of the yeast transcription factor, SPT5.
We isolated the human homologue, SUPT5H, of the yeast transcription factor, SPT5. The human homologue is 1088 aa long compared to… Expand
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