Skip to search formSkip to main content
You are currently offline. Some features of the site may not work correctly.

SPRED2 gene

Known as: SPRED2, Spred-2, FLJ31917 
 
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
SPRED2 deficiency may lead to lung ischemia–reperfusion injury via ERK1/2 signaling pathway activation
PurposeInflammatory changes during lung ischemia–reperfusion injury (IRI) are related to the activation of the extracellular… Expand
  • figure 1
  • figure 2
  • figure 3
2016
2016
Tumor suppressor Spred2 interaction with LC3 promotes autophagosome maturation and induces autophagy-dependent cell death
The tumor suppressor Spred2 (Sprouty-related EVH1 domain-2) induces cell death in a variety of cancers. However, the underlying… Expand
2016
2016
A Novel Role of Spred2 in the Colonic Epithelial Cell Homeostasis and Inflammation
Rapid and adequate mucosal healing is important for a remission of ulcerative colitis (UC) patients. Here, we examined whether… Expand
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
2015
2015
Negative regulation of TGFβ-induced lens epithelial to mesenchymal transition (EMT) by RTK antagonists.
An eclectic range of ocular growth factors with differing actions are present within the aqueous and vitreous humors that bathe… Expand
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
2013
2013
Evidence for downregulation of the negative regulator SPRED2 in clinical prostate cancer
Background:SPRED1 and 2 are key negative regulators of MAPK signalling in mammalian cells. Here, we investigate the expression… Expand
  • figure 1
  • figure 2
  • figure 3
2012
2012
Tyrosines 303/343/353 within the Sprouty-related domain of Spred2 are essential for its interaction with p85 and inhibitory effect on Ras/ERK activation.
Sprouty-related EVH1 domain (Spred) proteins modulate growth factor receptor signaling by inhibiting the Ras/ERK pathway. In… Expand
2011
2011
Regulation of human hepatocellular carcinoma cells by Spred2 and correlative studies on its mechanism.
Members of the Spred gene family are negative regulators of the Ras/Raf-1/ERK pathway, which has been associated with several… Expand
2010
2010
Spred2 is involved in imatinib-induced cytotoxicity in chronic myeloid leukemia cells.
Spreds, a recently established class of negative regulators of the Ras-ERK (extracellular signal-regulated kinase) pathway, are… Expand
2010
2010
Spred2 expression during mouse development
SPREDs (Sprouty‐related proteins with Ena/Vasodilator‐stimulated phosphoprotein homology‐1 domain) are known membrane‐associated… Expand
2010
2010
Spred2 inhibits TGF‐β1‐induced urokinase type plasminogen activator expression, cell motility and epithelial mesenchymal transition
TGF‐β1 is a potent inductor of malignance in cancer cells. TGF‐β1 stimulates the expression of extracellular matrix degrading… Expand
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy, Terms of Service, and Dataset License
ACCEPT & CONTINUE