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SPRED2 gene

Known as: SPRED2, Spred-2, FLJ31917 
National Institutes of Health

Papers overview

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2018
2018
SPRED2 deficiency may lead to lung ischemia–reperfusion injury via ERK1/2 signaling pathway activation
PurposeInflammatory changes during lung ischemia–reperfusion injury (IRI) are related to the activation of the extracellular… 
2016
2016
A Novel Role of Spred2 in the Colonic Epithelial Cell Homeostasis and Inflammation
Rapid and adequate mucosal healing is important for a remission of ulcerative colitis (UC) patients. Here, we examined whether… 
2016
2016
Tumor suppressor Spred2 interaction with LC3 promotes autophagosome maturation and induces autophagy-dependent cell death
The tumor suppressor Spred2 (Sprouty-related EVH1 domain-2) induces cell death in a variety of cancers. However, the underlying… 
2015
2015
Negative regulation of TGFβ-induced lens epithelial to mesenchymal transition (EMT) by RTK antagonists.
2013
2013
Evidence for downregulation of the negative regulator SPRED2 in clinical prostate cancer
Background:SPRED1 and 2 are key negative regulators of MAPK signalling in mammalian cells. Here, we investigate the expression… 
2012
2012
Tyrosines 303/343/353 within the Sprouty-related domain of Spred2 are essential for its interaction with p85 and inhibitory effect on Ras/ERK activation.
2011
2011
Regulation of human hepatocellular carcinoma cells by Spred2 and correlative studies on its mechanism.
2010
2010
Spred2 is involved in imatinib-induced cytotoxicity in chronic myeloid leukemia cells.
2010
2010
Spred2 expression during mouse development
SPREDs (Sprouty‐related proteins with Ena/Vasodilator‐stimulated phosphoprotein homology‐1 domain) are known membrane‐associated… 
2010
2010
Spred2 inhibits TGF‐β1‐induced urokinase type plasminogen activator expression, cell motility and epithelial mesenchymal transition
TGF‐β1 is a potent inductor of malignance in cancer cells. TGF‐β1 stimulates the expression of extracellular matrix degrading… 
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