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SPRED2 gene

Known as: SPRED2, Spred-2, FLJ31917 
 
National Institutes of Health

Topic mentions per year

Topic mentions per year

2003-2015
012320032015

Papers overview

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2016
2016
A Novel Role of Spred2 in the Colonic Epithelial Cell Homeostasis and Inflammation
Rapid and adequate mucosal healing is important for a remission of ulcerative colitis (UC) patients. Here, we examined whether… (More)
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2013
2013
Rheumatoid arthritis in Latin Americans enriched for Amerindian ancestry is associated with loci in chromosomes 1, 12, and 13, and the HLA class II region.
OBJECTIVE To identify susceptibility loci for rheumatoid arthritis (RA) in Latin American individuals with admixed European and… (More)
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2013
2013
Evidence for downregulation of the negative regulator SPRED2 in clinical prostate cancer
Background:SPRED1 and 2 are key negative regulators of MAPK signalling in mammalian cells. Here, we investigate the expression… (More)
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2012
2012
Tyrosines 303/343/353 within the Sprouty-related domain of Spred2 are essential for its interaction with p85 and inhibitory effect on Ras/ERK activation.
Sprouty-related EVH1 domain (Spred) proteins modulate growth factor receptor signaling by inhibiting the Ras/ERK pathway. In… (More)
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2011
2011
Regulation of human hepatocellular carcinoma cells by Spred2 and correlative studies on its mechanism.
Members of the Spred gene family are negative regulators of the Ras/Raf-1/ERK pathway, which has been associated with several… (More)
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2010
2010
Spred2 expression during mouse development.
SPREDs (Sprouty-related proteins with Ena/Vasodilator-stimulated phosphoprotein homology-1 domain) are known membrane-associated… (More)
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2010
2010
Spred2 is involved in imatinib-induced cytotoxicity in chronic myeloid leukemia cells.
Spreds, a recently established class of negative regulators of the Ras-ERK (extracellular signal-regulated kinase) pathway, are… (More)
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2010
2010
Spred2 inhibits TGF-beta1-induced urokinase type plasminogen activator expression, cell motility and epithelial mesenchymal transition.
TGF-beta1 is a potent inductor of malignance in cancer cells. TGF-beta1 stimulates the expression of extracellular matrix… (More)
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2009
2009
Spred2 interaction with the late endosomal protein NBR1 down-regulates fibroblast growth factor receptor signaling
The potential for modulation of growth factor signaling by endocytic trafficking of receptors is well recognized, but the… (More)
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2003
2003
Molecular cloning of mammalian Spred-3 which suppresses tyrosine kinase-mediated Erk activation.
We have reported on Spred-1 and Spred-2, which inhibit MAP kinase activation by interacting with c-kit and ras/raf. Here, we… (More)
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