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SPRED2 gene

Known as: SPRED2, Spred-2, FLJ31917 
 
National Institutes of Health

Papers overview

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2018
2018
SPRED2 deficiency may lead to lung ischemia–reperfusion injury via ERK1/2 signaling pathway activation
PurposeInflammatory changes during lung ischemia–reperfusion injury (IRI) are related to the activation of the extracellular… Expand
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2016
2016
Tumor suppressor Spred2 interaction with LC3 promotes autophagosome maturation and induces autophagy-dependent cell death
The tumor suppressor Spred2 (Sprouty-related EVH1 domain-2) induces cell death in a variety of cancers. However, the underlying… Expand
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2016
2016
A Novel Role of Spred2 in the Colonic Epithelial Cell Homeostasis and Inflammation
Rapid and adequate mucosal healing is important for a remission of ulcerative colitis (UC) patients. Here, we examined whether… Expand
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2015
2015
Negative regulation of TGFβ-induced lens epithelial to mesenchymal transition (EMT) by RTK antagonists.
An eclectic range of ocular growth factors with differing actions are present within the aqueous and vitreous humors that bathe… Expand
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2013
2013
Evidence for downregulation of the negative regulator SPRED2 in clinical prostate cancer
Background:SPRED1 and 2 are key negative regulators of MAPK signalling in mammalian cells. Here, we investigate the expression… Expand
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2012
2012
Tyrosines 303/343/353 within the Sprouty-related domain of Spred2 are essential for its interaction with p85 and inhibitory effect on Ras/ERK activation.
Sprouty-related EVH1 domain (Spred) proteins modulate growth factor receptor signaling by inhibiting the Ras/ERK pathway. In… Expand
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2012
2012
Defining an EPOR- Regulated Transcriptome for Primary Progenitors, including Tnfr-sf13c as a Novel Mediator of EPO- Dependent Erythroblast Formation
Certain concepts concerning EPO/EPOR action modes have been challenged by in vivo studies: Bcl-x levels are elevated in maturing… Expand
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2011
2011
Regulation of human hepatocellular carcinoma cells by Spred2 and correlative studies on its mechanism.
Members of the Spred gene family are negative regulators of the Ras/Raf-1/ERK pathway, which has been associated with several… Expand
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2010
2010
Spred2 expression during mouse development.
SPREDs (Sprouty-related proteins with Ena/Vasodilator-stimulated phosphoprotein homology-1 domain) are known membrane-associated… Expand
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2010
2010
Spred2 is involved in imatinib-induced cytotoxicity in chronic myeloid leukemia cells.
Spreds, a recently established class of negative regulators of the Ras-ERK (extracellular signal-regulated kinase) pathway, are… Expand
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