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SPP1 protein, human

Known as: Nephropontin protein, human, ETA-1 protein, human, Bone Sialoprotein 1 
Osteopontin (314 aa, ~35 kDa) is encoded by the human SPP1 gene. This protein is involved in the regulation of both tissue mineralization and cell… 
National Institutes of Health

Related topics

Related topics

19 relations
Bone Mineralization Regulation PathwayCell AdhesionCell MovementEnvironment-to-Cell Communication

Broader (1)

osteopontin

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2008
Highly Cited
2008
Engagement of the type I interferon receptor on dendritic cells inhibits T helper 17 cell development: role of intracellular osteopontin.
Highly Cited
2005
Highly Cited
2005
Post-translationally modified residues of native human osteopontin are located in clusters: identification of 36 phosphorylation and five O-glycosylation sites and their biological implications.
OPN (osteopontin) is an integrin-binding highly phosphorylated glycoprotein, recognized as a key molecule in a multitude of… 
Review
1999
Review
1999
Osteopontin Function in Pathology: Lessons from Osteopontin-Deficient Mice
Osteopontin (OPN) is a soluble secreted phosphoprotein that binds with high affinity to several different integrins. While… 
Highly Cited
1998
Highly Cited
1998
Transcriptional regulation of osteopontin gene in vivo by PEBP2αA/CBFA1 and ETS1 in the skeletal tissues
Osteopontin (Opn) and polyoma enhancer-binding protein (PEBP) 2αA/core binding factor (CBFA) 1 have been suggested to play… 
Highly Cited
1994
Highly Cited
1994
Modulation of crystal formation by bone phosphoproteins: structural specificity of the osteopontin-mediated inhibition of hydroxyapatite formation.
Osteopontin is a phosphorylated sialoprotein containing a conserved sequence of contiguous aspartic acid residues. This protein… 
Highly Cited
1994
Highly Cited
1994
Adhesive properties of osteopontin: regulation by a naturally occurring thrombin-cleavage in close proximity to the GRGDS cell-binding domain.
Osteopontin (OPN) is a secreted adhesive glycoprotein with a functional glycine-arginine-glycine-aspartate-serine (GRGDS) cell… 
Highly Cited
1993
Highly Cited
1993
Osteopontin mRNA is expressed by smooth muscle-derived foam cells in human atherosclerotic lesions of the aorta.
Osteopontin is a phosphorylated, sialic acid-rich, noncollagenous bone matrix protein containing the Arg-Gly-Asp-Ser amino acid… 
Highly Cited
1993
Highly Cited
1993
Structure and expression of the mRNA encoding urinary stone protein (osteopontin).
Highly Cited
1991
Highly Cited
1991
Expression of bone matrix proteins associated with mineralized tissue formation by adult rat bone marrow cells in vitro: Inductive effects of dexamethasone on the osteoblastic phenotype
The nature and tissue distribution of non‐collagenous bone proteins synthesized by adult rat bone marrow cells, induced to… 
Highly Cited
1983
Highly Cited
1983
Mechanism of immune suppression by ultraviolet irradiation in vivo. I. Evidence for the existence of a unique photoreceptor in skin and its role in photoimmunology
UV irradiation of mice causes a systemic immune alteration that can be detected either by suppression of the immunologic… 
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