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SPC24 gene

Known as: SPC24, NDC80 kinetochore complex component, SPBC24 SPC24, S. CEREVISIAE, HOMOLOG OF, SPC24 
National Institutes of Health

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1 relation

Broader (1)

Genes

Papers overview

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2018
2018
Dynamic acetylation of the kinetochore-associated protein HEC1 ensures accurate microtubule–kinetochore attachment
Faithful chromosome segregation during mitosis is critical for maintaining genome integrity in cell progeny and relies on… 
2018
2018
MUN (MERISTEM UNSTRUCTURED), encoding a SPC24 homolog of NDC80 kinetochore complex, affects development through cell division in Arabidopsis thaliana
Kinetochore, a protein super-complex on the centromere of chromosomes, mediates chromosome segregation during cell division by… 
2017
2017
SPC24 promotes osteosarcoma progression by increasing EGFR/MAPK signaling
In this study, we investigated the role of the spindle checkpoint protein SPC24 in osteosarcoma progression. SPC24 knockdown in… 
2015
2015
A novel prognostic biomarker SPC24 up-regulated in hepatocellular carcinoma
SPC24 is an important component of the nuclear division cycle 80 (Ndc80) kinetochore complex, which plays an essential role in… 
Highly Cited
2013
Highly Cited
2013
A structural basis for kinetochore recruitment of the Ndc80 complex via two distinct centromere receptors
The Ndc80 complex is the key microtubule‐binding element of the kinetochore. In contrast to the well‐characterized interaction of… 
2012
2012
Looping in on Ndc80 – How does a protein loop at the kinetochore control chromosome segregation?
Segregation of chromosomes during mitosis requires the interaction of dynamic microtubules with the kinetochore, a large protein… 
2010
2010
Perturbation of Spc25 expression affects meiotic spindle organization, chromosome alignment and spindle assembly checkpoint in mouse oocytes.
Spc25 is a component of the Ndc80 complex which consists of Ndc80, Nuf2, Spc24, and Spc25. Previous work has shown that Spc25 is… 
2002
2002
Spc24 interacts with Mps2 and is required for chromosome segregation, but is not implicated in spindle pole body duplication
Mps2 (monopolar spindle protein) is a coiled‐coil protein found at the spindle pole body (SPB) and at the nuclear envelope that… 
Highly Cited
2001
Highly Cited
2001
The Ndc80p Complex from Saccharomyces cerevisiae Contains Conserved Centromere Components and Has a Function in Chromosome Segregation
We have purified a complex from Saccharomyces cerevisiae containing the spindle components Ndc80p, Nuf2p, Spc25p, and Spc24p… 
Highly Cited
2001
Highly Cited
2001
The budding yeast proteins Spc24p and Spc25p interact with Ndc80p and Nuf2p at the kinetochore and are important for kinetochore clustering and checkpoint control
Here, we show that the budding yeast proteins Ndc80p, Nuf2p, Spc24p and Spc25p interact at the kinetochore. Consistently, Ndc80p… 
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