Skip to search formSkip to main contentSkip to account menu

SPAST gene

Known as: SPASTIN, SPG4, SPAST 
National Institutes of Health

Related topics

Related topics

2 relations
SPAST gene mutations found [Identifier] in Blood or Tissue by Molecular genetics method NarrativeSpastic paraplegia 4, autosomal dominant

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2012
Review
2012
Microtubule-severing enzymes at the cutting edge
ATP-dependent severing of microtubules was first reported in Xenopus laevis egg extracts in 1991. Two years later this… 
Highly Cited
2010
Highly Cited
2010
Hereditary spastic paraplegia proteins REEP1, spastin, and atlastin-1 coordinate microtubule interactions with the tubular ER network.
Hereditary spastic paraplegias (HSPs; SPG1-45) are inherited neurological disorders characterized by lower extremity spastic… 
Review
2010
Review
2010
Microtubule-severing enzymes.
Highly Cited
2010
Highly Cited
2010
Acetylation of Microtubules Influences Their Sensitivity to Severing by Katanin in Neurons and Fibroblasts
Here we investigated whether the sensitivity of microtubules to severing by katanin is regulated by acetylation of the… 
Highly Cited
2008
Highly Cited
2008
Structural basis of microtubule severing by the hereditary spastic paraplegia protein spastin
Spastin, the most common locus for mutations in hereditary spastic paraplegias, and katanin are related microtubule-severing AAA… 
Highly Cited
2008
Highly Cited
2008
Spastin Couples Microtubule Severing to Membrane Traffic in Completion of Cytokinesis and Secretion
Mutations in the gene encoding the microtubule (MT)‐severing protein spastin are the most common cause of hereditary spastic… 
Review
2007
Review
2007
Hereditary spastic paraplegias: an update
Purpose of reviewHereditary spastic paraplegias are a genetically heterogeneous group of diseases. Recent advances concerning… 
Highly Cited
2005
Highly Cited
2005
The hereditary spastic paraplegia protein spastin interacts with the ESCRT-III complex-associated endosomal protein CHMP1B.
Pure hereditary spastic paraplegia is characterized by length-dependent degeneration of the distal ends of long axons. Mutations… 
Highly Cited
2002
Highly Cited
2002
SPG20 is mutated in Troyer syndrome, an hereditary spastic paraplegia
Troyer syndrome (TRS) is an autosomal recessive complicated hereditary spastic paraplegia (HSP) that occurs with high frequency… 
Review
2001
Review
2001
Mutations in a newly identified GTPase gene cause autosomal dominant hereditary spastic paraplegia
The hereditary spastic paraplegias (HSPs; Strümpell-Lorrain syndrome, MIM number 18260) are a diverse class of disorders… 
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)