SPAST gene

Known as: SPASTIN, SPG4, SPAST 
 
National Institutes of Health

Papers overview

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Review
2012
Review
2012
ATP-dependent severing of microtubules was first reported in Xenopus laevis egg extracts in 1991. Two years later this… (More)
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Review
2012
Review
2012
Hereditary spastic paraplegia (SPG) is a clinically and genetically heterogeneous group of neurodegenerative disorders that are… (More)
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Highly Cited
2011
Highly Cited
2011
After partitioning of cytoplasmic contents by cleavage furrow ingression, animal cells remain connected by an intercellular… (More)
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Highly Cited
2010
Highly Cited
2010
Here we investigated whether the sensitivity of microtubules to severing by katanin is regulated by acetylation of the… (More)
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Highly Cited
2008
Highly Cited
2008
Neurons express two different microtubule-severing proteins, namely P60-katanin and spastin. Here, we performed studies on… (More)
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Highly Cited
2007
Highly Cited
2007
Chromosomes move toward mitotic spindle poles by a Pacman-flux mechanism linked to microtubule depolymerization: chromosomes… (More)
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Highly Cited
2006
Highly Cited
2006
BACKGROUND Hereditary spastic paraplegia (HSP) is a genetically heterogeneous neurodegenerative disease. The most frequent cause… (More)
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Highly Cited
2005
Highly Cited
2005
Hereditary spastic paraplegias (HSPs), a group of neurodegenerative disorders characterized by lower-extremity spasticity and… (More)
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Highly Cited
2005
Highly Cited
2005
There is broad agreement that cells reconfigure their microtubules through rapid bouts of assembly and disassembly, as described… (More)
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Highly Cited
1999
Highly Cited
1999
Autosomal dominant hereditary spastic paraplegia (AD-HSP) is a genetically heterogeneous neurodegenerative disorder characterized… (More)
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