Skip to search formSkip to main contentSkip to account menu

SPARC gene

Known as: Secreted Protein, Acidic, Cysteine-Rich (Osteonectin) Gene, SECRETED PROTEIN, ACIDIC, CYSTEINE-RICH, secreted protein acidic and cysteine rich 
This gene is involved in the regulation of cellular morphology, extracellular matrix deposition and cell cycle progression.
National Institutes of Health

Related topics

Related topics

10 relations
Bone remodelingCRIP1 protein, humanCalcium BindingCell Cycle Control

Broader (1)

Genes

Narrower (1)

SPARC wt Allele

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2011
Highly Cited
2011
Secreted Protein Acidic and Rich in Cysteine Is a Matrix Scavenger Chaperone
Secreted Protein Acidic and Rich in Cysteine (SPARC) is one of the major non-structural proteins of the extracellular matrix (ECM… 
2007
2007
Overexpression of SPARC protein contrasts with its transcriptional silencing by aberrant hypermethylation of SPARC CpG-rich region in endometrial carcinoma.
Secreted protein acidic and rich in cysteine (SPARC) is a secreted matricellular glycoprotein involved in crucial processes that… 
Highly Cited
2006
Highly Cited
2006
Correlation of reversion-inducing cysteine-rich protein with kazal motifs (RECK) and extracellular matrix metalloproteinase inducer (EMMPRIN), with MMP-2, MMP-9, and survival in colorectal cancer.
Highly Cited
2003
Highly Cited
2003
Matrix metalloproteinase inhibitor reversion‐inducing cysteine‐rich protein with Kazal motifs
The recently described reversion‐inducing cysteine‐rich protein with Kazal motifs (RECK) inhibits membrane Type 1 matrix… 
1995
1995
SPARC gene expression is reduced in early diabetes-related kidney growth.
Renal enlargement is a characteristic feature of diabetes in humans and experimental animals that may predict subsequent renal… 
Highly Cited
1994
Highly Cited
1994
Changes in calcium and collagen IV binding caused by mutations in the EF hand and other domains of extracellular matrix protein BM-40 (SPARC, osteonectin).
Recombinant expression in a human kidney cell-line was used to prepare mutant human BM-40 with deletions including the N-terminal… 
1994
1994
Osteonectin/SPARC regulates cellular secretion rates of fibronectin and laminin extracellular matrix proteins.
Osteonectin (OTN) has been implicated in controlling cell adhesivity onto substratum and extracellular matrix (ECM) remodeling… 
Highly Cited
1991
Highly Cited
1991
Expression of osteonectin, decorin, and transforming growth factor-beta 1 genes in fibroblasts cultured from patients with systemic sclerosis and morphea.
A characteristic feature of fibroblasts cultured from affected skin areas of patients with systemic sclerosis (SSc) and localized… 
Highly Cited
1990
Highly Cited
1990
cDNA sequence analysis of a 29-kDa cysteine-rich surface antigen of pathogenic Entamoeba histolytica.
A gamma gt11 cDNA library was constructed from poly(U)-Sepharose-selected Entamoeba histolytica trophozoite RNA in order to clone… 
Highly Cited
1988
Highly Cited
1988
Antigenic variation of a cysteine-rich protein in Giardia lamblia
The WB isolate of Giardia lamblia expresses a cysteine-rich 170-kD surface antigen (CRP170) that undergoes antigenic variation… 
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)