SNJ-1945
National Institutes of Health
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Purpose AMD is the leading cause of human vision loss after 65 years of age. Several mechanisms have been proposed: (1) age…
PURPOSE
Activation of calpains (calpain 2 and Lp82) in rodent lenses readily causes proteolysis and cataract formation. In…
Citation: Nakajima T, Shearer TR, Azuma M. Loss of calpastatin leads to activation of calpain in human lens epithelial cells…
The susceptibility of the normal cellular prion protein isoform, cellular prion protein (PrPC), to proteolytic digestion has been…
Purpose: Calpains are calcium-activated, intracellular, non-lysosomal, cysteine proteases that hydrolyze lens crystallins and…
Axonally specific microtubule-associated protein tau is an important component of neurofibrillary tangles found in AD (Alzheimer…
We have previously shown that a newly developed calpain inhibitor, SNJ-1945 (SNJ), with good aqueous solubility prevents the…
22 We have previously indicated that calpain-inbitor-1 prevents the heart from ischemia23 reperfusion injury associated with the…
Calpain-mediated proteolysis has been involved in neuronal cell death of retinal neurological degeneration. An aldehyde-based…