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SNJ-1945

National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
Contribution of Calpain and Caspases to Cell Death in Cultured Monkey RPE Cells
Purpose AMD is the leading cause of human vision loss after 65 years of age. Several mechanisms have been proposed: (1) age… 
2014
2014
Loss of calpastatin leads to activation of calpain in human lens epithelial cells.
PURPOSE Activation of calpains (calpain 2 and Lp82) in rodent lenses readily causes proteolysis and cataract formation. In… 
2014
2014
Lens Loss of Calpastatin Leads to Activation of Calpain in Human Lens Epithelial Cells
Citation: Nakajima T, Shearer TR, Azuma M. Loss of calpastatin leads to activation of calpain in human lens epithelial cells… 
2012
2012
Release of Full-Length PrPC from Cultured Neurons Following Neurotoxic Challenge
The susceptibility of the normal cellular prion protein isoform, cellular prion protein (PrPC), to proteolytic digestion has been… 
2011
2011
Involvement of Calpain 2 in Ionomycin-induced Cell Death in Cultured Mouse Lens Epithelial Cells
Purpose: Calpains are calcium-activated, intracellular, non-lysosomal, cysteine proteases that hydrolyze lens crystallins and… 
Highly Cited
2010
Highly Cited
2010
Dual vulnerability of tau to calpains and caspase-3 proteolysis under neurotoxic and neurodegenerative conditions
Axonally specific microtubule-associated protein tau is an important component of neurofibrillary tangles found in AD (Alzheimer… 
2010
2010
A cardioprotective agent of a novel calpain inhibitor, SNJ-1945, exerts beta1 actions on left ventricular mechanical work and energetics.
We have previously shown that a newly developed calpain inhibitor, SNJ-1945 (SNJ), with good aqueous solubility prevents the… 
2009
2009
Cardioprotective effects of a novel calpain inhibitor , SNJ-1945 for 1 reperfusion injury after cardioplegic cardiac arrest 2 3 4
22 We have previously indicated that calpain-inbitor-1 prevents the heart from ischemia23 reperfusion injury associated with the… 
2007
2007
Contribution of calpains to photoreceptor cell death in N-methyl-N-nitrosourea-treated rats
2006
2006
Retinal penetration of calpain inhibitors in rats after oral administration.
Calpain-mediated proteolysis has been involved in neuronal cell death of retinal neurological degeneration. An aldehyde-based… 
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