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SNJ-1945

National Institutes of Health

Papers overview

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2017
2017
Purpose AMD is the leading cause of human vision loss after 65 years of age. Several mechanisms have been proposed: (1) age… 
2014
2014
PURPOSE Activation of calpains (calpain 2 and Lp82) in rodent lenses readily causes proteolysis and cataract formation. In… 
2014
2014
Citation: Nakajima T, Shearer TR, Azuma M. Loss of calpastatin leads to activation of calpain in human lens epithelial cells… 
2012
2012
The susceptibility of the normal cellular prion protein isoform, cellular prion protein (PrPC), to proteolytic digestion has been… 
2011
2011
Purpose: Calpains are calcium-activated, intracellular, non-lysosomal, cysteine proteases that hydrolyze lens crystallins and… 
Highly Cited
2010
Highly Cited
2010
Axonally specific microtubule-associated protein tau is an important component of neurofibrillary tangles found in AD (Alzheimer… 
2010
2010
We have previously shown that a newly developed calpain inhibitor, SNJ-1945 (SNJ), with good aqueous solubility prevents the… 
2009
2009
22 We have previously indicated that calpain-inbitor-1 prevents the heart from ischemia23 reperfusion injury associated with the… 
2006
2006
Calpain-mediated proteolysis has been involved in neuronal cell death of retinal neurological degeneration. An aldehyde-based…