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SNJ-1945

National Institutes of Health

Papers overview

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2014
2014
SNJ‐1945, a calpain inhibitor, protects SH‐SY5Y cells against MPP+ and rotenone
Complex pathophysiology of Parkinson's disease involves multiple CNS cell types. Degeneration in spinal cord neurons alongside… 
2014
2014
The role of calpain in an in vivo model of oxidative stress-induced retinal ganglion cell damage.
2014
2014
Contribution of calpain to myoglobin efflux from cardiomyocytes during ischaemia and after reperfusion in anaesthetized rats
Calpain activation has a putative role in ischaemia‐reperfusion injury of cardiomyocytes. This study clarified the in vivo… 
2013
2013
Pharmacological analysis of the cortical neuronal cytoskeletal protective efficacy of the calpain inhibitor SNJ‐1945 in a mouse traumatic brain injury model
The efficacy of the amphipathic ketoamide calpain inhibitor SNJ‐1945 in attenuating calpain‐mediated degradation of the neuronal… 
Highly Cited
2012
Highly Cited
2012
Metabolic stress response implicated in diabetic retinopathy: The role of calpain, and the therapeutic impact of calpain inhibitor
2010
2010
Cardioprotective effects of a novel calpain inhibitor SNJ-1945 for reperfusion injury after cardioplegic cardiac arrest.
We have previously indicated that calpain inhibitor-1 prevents the heart from ischemia- reperfusion injury associated with the… 
2007
2007
Contribution of calpains to photoreceptor cell death in N-methyl-N-nitrosourea-treated rats
2006
2006
Amelioration of retinal degeneration and proteolysis in acute ocular hypertensive rats by calpain inhibitor ((1S)-1-((((1S)-1-benzyl-3-cyclopropylamino-2,3-di-oxopropyl)amino)carbonyl)-3-methylbutyl…
Highly Cited
2006
Highly Cited
2006
Calpain inhibition by alpha-ketoamide and cyclic hemiacetal inhibitors revealed by X-ray crystallography.
Calpains are intracellular calcium-activated cysteine proteases whose unregulated proteolysis following the loss of calcium… 
2006
2006
Retinal penetration of calpain inhibitors in rats after oral administration.
Calpain-mediated proteolysis has been involved in neuronal cell death of retinal neurological degeneration. An aldehyde-based… 
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