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SN-38-Loaded Polymeric Micelles NK012

Known as: NK012 
A formulation consisting of polymeric micelles loaded with the irinotecan metabolite SN-38 with potential antineoplastic activity. SN-38-loaded… Expand
National Institutes of Health

Papers overview

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2016
2016
PurposeThis study evaluated the safety, tolerability, pharmacokinetics, and maximum tolerated dose (MTD) and recommended phase II… Expand
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2012
2012
Biodegradable micelles with sheddable poly(ethylene glycol) shells were fabricated based on poly(ethylene glycol)-block-poly… Expand
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Review
2011
Review
2011
Polymeric micelles are ideally suited to exploit the EPR effect, and they have been used for the delivery of a range of… Expand
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Highly Cited
2010
Highly Cited
2010
Purpose: We conducted a first-in-human phase I study to determine the dose-limiting toxicity (DLT), evaluate the pharmacokinetic… Expand
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2010
2010
Purpose: To clarify the effect of bevacizumab on NK012 therapy in mice bearing U87MG glioblastoma orthotopic xenografts in… Expand
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2009
2009
Recent published reports on clinical trials of CPT-11 indicate the effectiveness of this compound, a prodrug of SN-38, against… Expand
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Review
2008
Review
2008
Polymeric micelles are expected to increase the accumulation of drugs in tumor tissues utilizing the EPR effect and to… Expand
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2008
2008
It has been recently reported that NK012, a 7-ethyl-10-hydroxy-camptothecin (SN-38)-releasing nanodevice, markedly enhances the… Expand
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2008
2008
The authors reported in a previous study that NK012, a 7-ethyl-10-hydroxy-camptothecin (SN-38)-releasing nano-system, exhibited… Expand
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Highly Cited
2006
Highly Cited
2006
7-Ethyl-10-hydroxy-camptothecin (SN-38), a biological active metabolite of irinotecan hydrochloride (CPT-11), has potent… Expand
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