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SN-38-Loaded Polymeric Micelles NK012

Known as: NK012 
A formulation consisting of polymeric micelles loaded with the irinotecan metabolite SN-38 with potential antineoplastic activity. SN-38-loaded… Expand
National Institutes of Health

Papers overview

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2016
2016
Abstract Convection-enhanced delivery (CED) of therapeutic agents is a promising local delivery technique that has been… Expand
2012
2012
Biodegradable micelles with sheddable poly(ethylene glycol) shells were fabricated based on poly(ethylene glycol)-block-poly… Expand
Review
2011
Review
2011
  • Y. Matsumura
  • Advanced drug delivery reviews
  • 2011
  • Corpus ID: 42320811
Polymeric micelles are ideally suited to exploit the EPR effect, and they have been used for the delivery of a range of… Expand
Highly Cited
2010
Highly Cited
2010
Purpose: We conducted a first-in-human phase I study to determine the dose-limiting toxicity (DLT), evaluate the pharmacokinetic… Expand
Highly Cited
2009
Highly Cited
2009
Recent published reports on clinical trials of CPT‐11 indicate the effectiveness of this compound, a prodrug of SN‐38, against… Expand
Review
2008
Review
2008
  • Y. Matsumura
  • Advanced drug delivery reviews
  • 2008
  • Corpus ID: 13369058
Polymeric micelles are expected to increase the accumulation of drugs in tumor tissues utilizing the EPR effect and to… Expand
Review
2008
Review
2008
  • Y. Matsumura
  • Japanese journal of clinical oncology
  • 2008
  • Corpus ID: 11735083
The purpose of drug delivery systems in cancer chemotherapy is to achieve selective delivery of anti-cancer agents to cancer… Expand
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Highly Cited
2008
Highly Cited
2008
It has been recently reported that NK012, a 7-ethyl-10-hydroxy-camptothecin (SN-38)-releasing nanodevice, markedly enhances the… Expand
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Highly Cited
2008
Highly Cited
2008
The authors reported in a previous study that NK012, a 7‐ethyl‐10‐hydroxy‐camptothecin (SN‐38)‐releasing nano‐system, exhibited… Expand
Highly Cited
2006
Highly Cited
2006
7-Ethyl-10-hydroxy-camptothecin (SN-38), a biological active metabolite of irinotecan hydrochloride (CPT-11), has potent… Expand
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