SN-38-Loaded Polymeric Micelles NK012

Known as: NK012 
A formulation consisting of polymeric micelles loaded with the irinotecan metabolite SN-38 with potential antineoplastic activity. SN-38-loaded… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

2006-2018
0520062018

Papers overview

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2016
2016
Convection-enhanced delivery (CED) of therapeutic agents is a promising local delivery technique that has been extensively… (More)
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2015
2015
Cisplatin (CDDP) and paclitaxel (PTX) are two established chemotherapeutic drugs used in combination for the treatment of many… (More)
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2010
2010
PURPOSE We conducted a first-in-human phase I study to determine the dose-limiting toxicity (DLT), evaluate the pharmacokinetic… (More)
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2010
2010
PURPOSE To clarify and compare the antitumor effects and specific biodistribution of NK012, an SN-38-incorporating polymeric… (More)
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2010
2010
PURPOSE To clarify the effect of bevacizumab on NK012 therapy in mice bearing U87MG glioblastoma orthotopic xenografts in… (More)
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2009
2009
Recent published reports on clinical trials of CPT-11 indicate the effectiveness of this compound, a prodrug of SN-38, against… (More)
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2008
2008
It has been recently reported that NK012, a 7-ethyl-10-hydroxy-camptothecin (SN-38)-releasing nanodevice, markedly enhances the… (More)
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2008
2008
The authors reported in a previous study that NK012, a 7-ethyl-10-hydroxy-camptothecin (SN-38)-releasing nano-system, exhibited… (More)
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2008
2008
Human pancreatic cancer is generally hypovascular in nature and rich in interstitium. These pathological barriers may contribute… (More)
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Highly Cited
2006
Highly Cited
2006
7-Ethyl-10-hydroxy-camptothecin (SN-38), a biological active metabolite of irinotecan hydrochloride (CPT-11), has potent… (More)
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