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SN-38-Loaded Polymeric Micelles NK012

Known as: NK012 
A formulation consisting of polymeric micelles loaded with the irinotecan metabolite SN-38 with potential antineoplastic activity. SN-38-loaded… 
National Institutes of Health

Related topics

Related topics

1 relation
NCIt Antineoplastic Agent Terminology

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
Improving the carrier stability and drug loading of unimolecular micelle-based nanotherapeutics for acid-activated drug delivery and enhanced antitumor therapy.
Nanomedicines based on unimolecular micelles (UMs) have shown unique advantages such as high micellar stability, programmed cargo… 
2015
2015
A phase II study of NK012, a polymeric micelle formulation of SN-38, in colorectal cancer patients who had received prior oxaliplatin-based regimen.
3527 Background: NK012 is a micelle-forming macromolecular prodrug of SN-38, an active metabolite of irinotecan. In the completed… 
2012
2012
Fabrication of biodegradable micelles with sheddable poly(ethylene glycol) shells as the carrier of 7-ethyl-10-hydroxy-camptothecin.
2012
2012
A phase I study of NK012 in combination with 5-fluorouracil with or without leucovorin in patients (pts) with advanced solid tumors.
e13076 Background: NK012 is a micelle-forming macromolecular prodrug of EHC (7-ethyl-10-hydroxycamptothecin), also known as SN-38… 
2011
2011
Phase II study of NK012 in relapsed small cell lung cancer.
7079 Background: NK012 is a topoisomerase I (TI) inhibitor designed as a micelle-forming macromolecule to release a gradual and… 
2009
2009
NK012. Topoisomerase I inhibitor apoptosis inducer oncolytic
2008
2008
A phase I dose-escalation study of NK012
2538 Background: NK012 is a micelle-forming macromolecular prodrug of EHC (7-ethyl-10-hydroxycamptothecin), also known as SN-38… 
2008
2008
423 POSTER Phase I dose escalation study of NK012, polymer micelle of irinotecan metabolite SN-38, in patients with advanced cancer
2008
2008
NOVEL SN-38-INCORPORATED POLYMERIC MICELLES, NK012, ERADICATE LUNG METASTASES AND INCREASE SURVIVAL IN THE MURINE RENAL CANCER MODEL
2006
2006
Superior antitumor activity of NK012, 7-ethyl-10-hydroxycamptothecin-incorporating micellar nanoparticle, to irinotecan
Proc Amer Assoc Cancer Res, Volume 47, 2006 3062 Irinotecan hydrochloride (CPT-11) is clinically used to treat various tumors… 
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