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The SLC9 gene family encodes Na+/H+ exchangers (NHEs). These transmembrane proteins transport ions across lipid bilayers in a… Expand The pH and lumenal environment of intracellular organelles is considered essential for protein sorting and trafficking through… Expand The proximal tubule is critical for whole-organism volume and acid–base homeostasis by reabsorbing filtered water, NaCl… Expand NHE8 is a newly identified NHE isoform expressed in rat intestine. To date, the kinetic characteristics and the intestinal… Expand We previously demonstrated that there are developmental changes in proximal tubule Na(+)/H(+) exchanger (NHE) activity. There is… Expand In mammalian cells, four Na+/H+ exchangers (NHE6 - NHE9) are localized to intracellular compartments. NHE6 and NHE9 are… Expand NHE8 is expressed in the apical membrane of the proximal tubule and is predicted to be a Na+/H+ exchanger on the basis of its… Expand Four isoforms of the Na+/H+ exchanger (NHE6–NHE9) are distributed to intracellular compartments in human cells. They are… Expand In situ hybridization studies demonstrated that Na+/H+ exchanger NHE8 is expressed in kidney proximal tubules. Although membrane… Expand Although Na(+)/H(+) exchanger isoform 3 (NHE3) mediates most Na(+)/H(+) exchange in the proximal tubule, studies of NHE3/NHE2… Expand