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Signal transduction by small ubiquitin-like modifier (SUMO) regulates a myriad of nuclear processes. Here we report on the role… Expand Significance The anaphase-promoting complex/cyclosome (APC/C) is a large E3 ubiquitin ligase that controls progression through… Expand ABSTRACT Human cytomegalovirus (HCMV) deregulates the cell cycle by several means, including inactivation of the anaphase… Expand The anaphase-promoting complex/cyclosome (APC/C) is a multi-subunit E3 ubiquitin ligase that initiates chromosome segregation and… Expand The anaphase-promoting complex/cyclosome (APC/C) is an E3 ubiquitin ligase that is involved in regulating cell-cycle progression… Expand ABSTRACT Infection of quiescent cells by human cytomegalovirus (HCMV) elicits severe cell cycle deregulation, resulting in a G1/S… Expand The anaphase-promoting complex or cyclosome (APC) is an unusually complicated ubiquitin ligase, composed of 13 core subunits and… Expand BACKGROUND
Chromosome segregation and mitotic exit depend on activation of the anaphase-promoting complex (APC) by the substrate… Expand The anaphase-promoting complex is composed of eight protein subunits, including BimE (APC1), CDC27 (APC3), CDC16 (APC6), and… Expand Proteins that interact with both cytoskeletal and membrane components are candidates to modulate membrane trafficking. The tumor… Expand