SKIL gene

Known as: SKI-like proto-oncogene, SKIL, SKI-LIKE 
This gene plays a role in signal transduction. It is involved in regulating whether cells undergo differentiation or division.
National Institutes of Health

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Cell Proliferation Regulatory ProcessSKIL protein, humanSignal TransductionTranscriptional Regulation
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Papers overview

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2008
2008
TGFbeta-Smad2 signaling regulates the Cdh1-APC/SnoN pathway of axonal morphogenesis.
Axon growth is critical to the establishment of neuronal connectivity. The E3 ubiquitin ligase Cdh1-anaphase-promoting complex… (More)
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2005
2005
Cytoplasmic SnoN in normal tissues and nonmalignant cells antagonizes TGF-beta signaling by sequestration of the Smad proteins.
TGF-beta is a ubiquitously expressed cytokine that signals through the Smad proteins to regulate many diverse cellular processes… (More)
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Highly Cited
2005
Highly Cited
2005
NEDD4-2 (neural precursor cell expressed, developmentally down-regulated 4-2) negatively regulates TGF-beta (transforming growth factor-beta) signalling by inducing ubiquitin-mediated degradation of…
Inhibitory Smad, Smad7, is a potent inhibitor of TGF-beta (transforming growth factor-beta) superfamily signalling. By binding to… (More)
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Review
2004
Review
2004
Regulation of the TGFβ signalling pathway by ubiquitin-mediated degradation
The transforming growth factor-β (TGFβ) superfamily controls a plethora of biological responses, and alterations in its… (More)
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Highly Cited
2004
Highly Cited
2004
A novel mechanism by which hepatocyte growth factor blocks tubular epithelial to mesenchymal transition.
Hepatocyte growth factor (HGF) is a potent antifibrotic cytokine that blocks tubular epithelial to mesenchymal transition (EMT… (More)
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Review
2004
Review
2004
Ski and SnoN: negative regulators of TGF-beta signaling.
Ski and SnoN are unique proto-oncoproteins in that they can induce both oncogenic transformation and terminal muscle… (More)
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2003
2003
Downregulation of Smad transcriptional corepressors SnoN and Ski in the fibrotic kidney: an amplification mechanism for TGF-beta1 signaling.
TGF-beta1 is a profibrotic cytokine that plays a central role in the onset and progression of chronic renal diseases. The… (More)
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Highly Cited
2001
Highly Cited
2001
The anaphase-promoting complex mediates TGF-beta signaling by targeting SnoN for destruction.
Degradation of SnoN is thought to play an important role in the transactivation of TGF-beta responsive genes. We demonstrate that… (More)
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Highly Cited
2001
Highly Cited
2001
TGF-β induces assembly of a Smad2–Smurf2 ubiquitin ligase complex that targets SnoN for degradation
The receptor-regulated Smad proteins are essential intracellular mediators of signal transduction by the transforming growth… (More)
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Highly Cited
1998
Highly Cited
1998
The highly conserved, coregulated SNO and SNZ gene families in Saccharomyces cerevisiae respond to nutrient limitation.
SNZ1, a member of a highly conserved gene family, was first identified through studies of proteins synthesized in stationary… (More)
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