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SK053

National Institutes of Health

Papers overview

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2016
2016
THIOL-REACTIVE PEPTIDOMIMETIC SK053 TARGETS DIMERIC PEROXIREDOXINS IN HUMAN LYMPHOMA CELL LINES
Peroxiredoxins (PRDXs) are thioredoxin-family antioxidant enzymes that scavenge peroxides. PRDXs are abundantly expressed in… 
2015
2015
Abstract 5347: SK053, a small molecule inhibitor of enzymes involved in allosteric disulfide bonds formation, shows potent anti-leukemic effects and induces differentiation of human AML cells
Although differentiation-inducing agents have significantly improved the management of acute promyelocytic leukemia, no… 
2014
2014
SK053, an Inhibitor of Enzymes Involved in Allosteric Disulfide Bonds Formation, Targets Expression of Histone Genes and Induces Differentiation of Human AML Cell
Targeting epigenetic modifiers, such as histone deacetylases, bromodomain and extraterminal (BET) domains or methyltransferases… 
2012
2012
Studies toward novel peptidomimetic inhibitors of thioredoxin-thioredoxin reductase system.
Thioredoxins (Trx) are ubiquitous multifunctional low-molecular weight proteins that together with thioredoxin reductases (TrxR… 
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