SK&F 29661

7-(Aminosulfonyl)-1,2,3,4-tetrahydroisoquinoline (SK&F 29661, 1) is a potent inhibitor of the enzyme phenylethanolamine N… Expand

Several drugs that block epinephrine synthesis by inhibiting phenylethanolamine N-methyltransferase (PNMT) lower blood pressure… Expand

STUDY OBJECTIVE - The aim of the study was to investigate adrenaline synthesis in atrial and ventricular homogenates. DESIGN… Expand

We studied in vitro and in vivo epinephrine (E) synthesis by rat lung. Nine days after removal of the adrenal medullas… Expand

Experiments were undertaken to determine whether the steroid-dependent lordosis response of female guinea pigs is under… Expand

This study was undertaken to investigate whether hypothalamic adrenaline is involved in pulsatile LH release in rats. Various… Expand

Adrenergic mechanisms influence surfactant metabolism; however the nature and importance of catechol-mediated regulation is… Expand

SummarySK&F 29661 (1,2,3,4-tetrahydro-7-isoquinoline-sulfonamide) is a potent and selective in vitro and in vivo inhibitor of… Expand

Rapid bleeding in normotensive Sprague-Dawley rats produces a marked fall in arterial blood pressure and a profound decrease in… Expand

SK&F 29661 is an effective, reversible inhibitor of both central nervous system and adrenal phenylethanolamine N-methyl… Expand