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SK&F 29661

Known as: SK&F-29661, SKF 29661, SKF-29661 
National Institutes of Health

Papers overview

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2004
2004
Studies on the long term effects of SK&F 29661 upon adrenal catecholamines
SummarySK&F 29661 (1,2,3,4-tetrahydro-7-isoquinoline-sulfonamide) is a potent and selective in vitro and in vivo inhibitor of… Expand
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1997
1997
Examination of the role of the acidic hydrogen in imparting selectivity of 7-(aminosulfonyl)-1,2,3,4-tetrahydroisoquinoline (SK&F 29661) toward inhibition of phenylethanolamine N-methyltransferase vs…
7-(Aminosulfonyl)-1,2,3,4-tetrahydroisoquinoline (SK&F 29661, 1) is a potent inhibitor of the enzyme phenylethanolamine N… Expand
1993
1993
Glucocorticoid hypertension and nonadrenal phenylethanolamine N-methyltransferase.
Several drugs that block epinephrine synthesis by inhibiting phenylethanolamine N-methyltransferase (PNMT) lower blood pressure… Expand
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1991
1991
Epinephrine synthesis by rat arteries.
Carotid artery and aorta homogenates synthesized epinephrine (E) from norepinephrine (NE) in the presence of S-adenosylmethionine… Expand
1990
1990
Cardiac atria and ventricles contain different inducible adrenaline synthesising enzymes.
STUDY OBJECTIVE - The aim of the study was to investigate adrenaline synthesis in atrial and ventricular homogenates. DESIGN… Expand
1990
1990
Lung epinephrine synthesis.
We studied in vitro and in vivo epinephrine (E) synthesis by rat lung. Nine days after removal of the adrenal medullas… Expand
1989
1989
Inhibition of guinea pig lordosis behavior by the phenylethanolamine N-methyltransferase (PNMT) inhibitor SKF-64139: Mediation by α noradrenergic receptors
Experiments were undertaken to determine whether the steroid-dependent lordosis response of female guinea pigs is under… Expand
1986
1986
Effects of various inhibitors of phenylethanolamine N-methyltransferase on pulsatile release of LH in ovariectomized rats.
This study was undertaken to investigate whether hypothalamic adrenaline is involved in pulsatile LH release in rats. Various… Expand
1984
1984
[Adrenal epinephrine and the regulation of pulmonary surfactant release in neonatal rabbits].
Adrenergic mechanisms influence surfactant metabolism; however the nature and importance of catechol-mediated regulation is… Expand
1979
1979
Studies on SK&F 29661, an organ-specific inhibitor of phenylethanolamine N-methyltransferase.
SK&F 29661 is an effective, reversible inhibitor of both central nervous system and adrenal phenylethanolamine N-methyl… Expand
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