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SIRPa-Fc Fusion Protein TTI-621

Known as: SIRPaFc, TTI 621, TTI-621 
A soluble recombinant antibody-like fusion protein composed of the N-terminal CD47 binding domain of human signal-regulatory protein alpha (SIRPa… 
National Institutes of Health

Related topics

Related topics

1 relation
antigen binding

Papers overview

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2019
2019
Designing a multifunctional staphylokinase variant (SAK-2RGD-TTI) with appropriate thrombolytic activity in vitro
Thrombin, platelets, and plasmin are three key factors involved in hemostasis and thrombolysis. Thrombolytic therapy with… 
2018
2018
Intralesional Injection of the CD47-blocking immune checkpoint inhibitor TTI-621 (SIRPaFc) induces antitumor activity in patients with relapsed/refractory mycosis fungoides and Sézary syndrome…
2017
2017
TTI-621 (SIRPαFc), an Immune Checkpoint Inhibitor Blocking the CD47 “Do Not Eat” Signal, Induces Objective Responses in Patients with Advanced, Relapsed/Refractory Diffuse Large B-Cell Lymphoma…
Background CD47 is an immune checkpoint that binds to signal regulatory protein alpha (SIRPα) and delivers a "do not eat" signal… 
2017
2017
Abstract 2653: The anti-myeloma activity of TTI-621 (SIRPαFc), a CD47-blocking immunotherapeutic, is enhanced when combined with a proteasome inhibitor
CD47 is transmembrane glycoprotein that delivers an anti-phagocytic (“do not eat”) signal by binding to its receptor, signal… 
2017
2017
Effects of TTI-621 (SIRPαFc) on CD47 and serum cytokines associated with phagocytosis in subjects with relapsed, refractory hematologic malignancies: Pharmacodynamic findings from a first-in-human…
112Background: CD47 delivers an anti-phagocytic (“do not eat”) signal by binding SIRPα on macrophages and is overexpressed on… 
2017
2017
A phase 1 dose-escalation trial of intratumoral TTI-621, a novel immune checkpoint inhibitor targeting CD47, in subjects with relapsed or refractory percutaneously-accessible solid tumors and mycosis…
TPS3101Background: CD47 is an immune checkpoint that binds to signal regulatory protein alpha (SIRPα) and delivers a "do not eat… 
2016
2016
Study on system latency reduction based on Shorten TTI
System latency is one key metric that guides LTE design. Shortening TTI by reducing subframe length along with backward… 
2013
2013
Ray-based gridded tomography for tilted transversely isotropic media
Reflection tomography in the migrated domain can help reconstruct heterogeneous, anisotropic velocity fields needed for accurate… 
2012
2012
Anisotropic velocity analysis of P-wave reflection and borehole data
Efficient application of the modern imaging technology requires development of velocityanalysis methods that take anisotropy into… 
1969
1969
The Effects of Maternal Employment on the Scholastic Performance of Children
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