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SIB 1508Y
Known as:
SIB-1508Y
National Institutes of Health
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Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2008
2008
Pharmacological characterization of (S)-(2)-5-ethynyl-3-(1-methyl-2-pyrrolidinyl)pyridine HCl (SIB-1508Y, Altinicline), a novel nicotinic acetylcholine receptor agonist
T. Rao
,
P. Adams
,
+4 authors
N. Cosford
Brain Research
2008
Corpus ID: 23547813
2006
2006
Expedient five-step synthesis of SIB-1508Y from natural nicotine.
F. Wagner
,
D. Comins
The Journal of organic chemistry
2006
Corpus ID: 5853389
Altinicline (SIB-1508Y), an anti-Parkinson's agent, was prepared in five steps from natural nicotine in 32% overall yield via a…
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2006
2006
Randomized placebo-controlled study of the nicotinic agonist SIB-1508Y in Parkinson disease
Neurology
2006
Corpus ID: 31720763
This randomized, placebo-controlled, 5-week Phase II trial evaluated the safety and tolerability of SIB-1508Y, a selective α4β2…
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Highly Cited
2000
Highly Cited
2000
Antidepressant-like effects of the subtype-selective nicotinic acetylcholine receptor agonist, SIB-1508Y, in the learned helplessness rat model of depression
S. Ferguson
,
J. Brodkin
,
G. Kenneth Lloyd
,
F. Menzaghi
Psychopharmacology
2000
Corpus ID: 7174735
Abstract.Rationale: Epidemiological studies of smokers suggest that there is a link between nicotine and depression. Nonetheless…
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2000
2000
Recombinant human receptors and functional assays in the discovery of altinicline (SIB-1508Y), a novel acetylcholine-gated ion channel (nAChR) agonist.
N. Cosford
,
L. Bleicher
,
+7 authors
I. McDonald
Pharmaceutica acta Helvetiae
2000
Corpus ID: 12087277
Highly Cited
1999
Highly Cited
1999
Nicotinic acetylcholine receptor agonist SIB-1508Y improves cognitive functioning in chronic low-dose MPTP-treated monkeys.
J. Schneider
,
J. Tinker
,
M. Van Velson
,
F. Menzaghi
,
G. Lloyd
The Journal of pharmacology and experimental…
1999
Corpus ID: 22366696
Monkeys that receive chronic low-dose 1-methyl-4-phenyl-1,2,3, 6-tetrahydropyridine (MPTP) administration have difficulty…
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Highly Cited
1998
Highly Cited
1998
Effects of SIB‐1508Y, a novel neuronal nicotinic acetylcholine receptor agonist, on motor behavior in parkinsonian monkeys
J. Schneider
,
A. Pope-Coleman
,
M. Van Velson
,
F. Menzaghi
,
G. Kenneth Lloyd
Movement disorders : official journal of the…
1998
Corpus ID: 38665656
The potential antiparkinsonian effects of the centrally acting, subtype‐selective neuronal nicotinic acetylcholine receptor…
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Review
1998
Review
1998
The potential of subtype-selective neuronal nicotinic acetylcholine receptor agonists as therapeutic agents.
G. Lloyd
,
F. Menzaghi
,
+14 authors
L. A. McDonald
Life sciences
1998
Corpus ID: 1405429
Review
1998
Review
1998
Effects of the nicotinic acetylcholine receptor agonist SIB‐1508Y on object retrieval performance in MPTP‐Treated monkeys: Comparison with levodopa treatment
J. Schneider
,
M. Van Velson
,
F. Menzaghi
,
G. Lloyd
Annals of neurology
1998
Corpus ID: 25418414
This study assessed the relative potencies of levodopa/benserazide and the nicotinic acetylcholine receptor agonist SIB‐1508Y on…
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Highly Cited
1996
Highly Cited
1996
(S)-(-)-5-ethynyl-3-(1-methyl-2-pyrrolidinyl)pyridine maleate (SIB-1508Y): a novel anti-parkinsonian agent with selectivity for neuronal nicotinic acetylcholine receptors.
N. Cosford
,
L. Bleicher
,
+18 authors
I. McDonald
Journal of medicinal chemistry
1996
Corpus ID: 24844160
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