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SHOC2 gene

Known as: KIAA0862, SHOC2 leucine-rich repeat scaffold protein, SUR8 
 
National Institutes of Health

Topic mentions per year

Topic mentions per year

1998-2017
024619982017

Papers overview

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2014
2014
A Novel SHOC2 Variant in Rasopathy.
Rasopathies are a group of genetic disorders caused by germline mutations in multiple genes of the Extracellular signal-Regulated… (More)
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2014
2014
Phenotypic variability associated with the invariant SHOC2 c.4A>G (p.Ser2Gly) missense mutation.
Noonan-like syndrome with loose anagen hair (NS/LAH; OMIM 607721) is a developmental disorder clinically related to Noonan… (More)
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2014
2014
Rare copy number variations containing genes involved in RASopathies: deletion of SHOC2 and duplication of PTPN11
RASopathies are a group of disorders related to Noonan syndrome that with dysregulated RAS-mitogen-activated protein kinase (MAPK… (More)
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2012
2012
Shoc2 Is Targeted to Late Endosomes and Required for Erk1/2 Activation in EGF-Stimulated Cells
Shoc2 is the putative scaffold protein that interacts with RAS and RAF, and positively regulates signaling to extracellular… (More)
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2011
2011
Sur8/Shoc2 involves both inhibition of differentiation and maintenance of self-renewal of neural progenitor cells via modulation of extracellular signal-regulated kinase signaling.
Sur8/Shoc2 is a scaffold protein that regulates the Ras-extracellular signal-regulated kinase (ERK) pathway. However, the roles… (More)
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2010
2010
The scaffold protein Shoc2/SUR-8 accelerates the interaction of Ras and Raf.
Shoc2/SUR-8 positively regulates Ras/ERK MAP kinase signaling by serving as a scaffold for Ras and Raf. Here, we examined the… (More)
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2006
2006
Erbin inhibits RAF activation by disrupting the sur-8-Ras-Raf complex.
Erbin is a member of the LAP (leucine-rich repeat (LRR) and PDZ domain) family. It inhibits Ras-mediated activation of ERK in… (More)
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2005
2005
Suppressor of cytokine signaling-2 modulates the fibrogenic actions of GH and IGF-I in intestinal mesenchymal cells.
Growth hormone (GH) and IGF-I play important roles in wound healing during intestinal injury and inflammation, but there is also… (More)
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1999
1999
Characterization of a novel Ras-binding protein Ce-FLI-1 comprising leucine-rich repeats and gelsolin-like domains.
Ras proteins are conserved from yeasts to mammals and implicated in regulation of the actin cytoskeleton. The flightless-1 (fli-1… (More)
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Highly Cited
1998
Highly Cited
1998
SUR-8, a Conserved Ras-Binding Protein with Leucine-Rich Repeats, Positively Regulates Ras-Mediated Signaling in C. elegans
We describe the identification and characterization of a novel gene, sur-8, that positively regulates Ras-mediated signal… (More)
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