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SHOC2 gene

Known as: KIAA0862, SHOC2 leucine-rich repeat scaffold protein, SUR8 
 
National Institutes of Health

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shoc2 gene analysis

Papers overview

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2014
2014
Rare copy number variations containing genes involved in RASopathies: deletion of SHOC2 and duplication of PTPN11
BackgroundRASopathies are a group of disorders related to Noonan syndrome that with dysregulated RAS-mitogen-activated protein… Expand
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2014
2014
HUWE1 is a molecular link controlling RAF-1 activity supported by the Shoc2 scaffold.
Scaffold proteins play a critical role in controlling the activity of the extracellular signal-regulated kinase 1/2 (ERK1/2… Expand
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2014
2014
Phenotypic variability associated with the invariant SHOC2 c.4A>G (p.Ser2Gly) missense mutation.
Noonan-like syndrome with loose anagen hair (NS/LAH; OMIM 607721) is a developmental disorder clinically related to Noonan… Expand
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2013
2013
An MRAS, SHOC2, and SCRIB complex coordinates ERK pathway activation with polarity and tumorigenic growth.
SHOC2 is mutated in Noonan syndrome and plays a key role in the activation of the ERK-MAPK pathway, which is upregulated in the… Expand
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2012
2012
The space optical clocks project: Development of high-performance transportable and breadboard optical clocks and advanced subsystems
The use of ultra-precise optical clocks in space (“master clocks”) will allow for a range of new applications in the fields of… Expand
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2010
2010
The scaffold protein Shoc2/SUR-8 accelerates the interaction of Ras and Raf.
Shoc2/SUR-8 positively regulates Ras/ERK MAP kinase signaling by serving as a scaffold for Ras and Raf. Here, we examined the… Expand
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2010
2010
Ras and Calcium Signaling Pathways Converge at Raf1 via the Shoc2 Scaffold Protein
Activation of Raf1 at the plasma membrane requires not only Ras activation but also an increase in Ca2+ concentration or… Expand
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2005
2005
Suppressor of cytokine signaling-2 modulates the fibrogenic actions of GH and IGF-I in intestinal mesenchymal cells.
Growth hormone (GH) and IGF-I play important roles in wound healing during intestinal injury and inflammation, but there is also… Expand
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1999
1999
Characterization of a novel Ras-binding protein Ce-FLI-1 comprising leucine-rich repeats and gelsolin-like domains.
Ras proteins are conserved from yeasts to mammals and implicated in regulation of the actin cytoskeleton. The flightless-1 (fli-1… Expand
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Highly Cited
1998
Highly Cited
1998
SUR-8, a Conserved Ras-Binding Protein with Leucine-Rich Repeats, Positively Regulates Ras-Mediated Signaling in C. elegans
We describe the identification and characterization of a novel gene, sur-8, that positively regulates Ras-mediated signal… Expand
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