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SHOC2 gene
Known as:
KIAA0862
, SHOC2 leucine-rich repeat scaffold protein
, SUR8
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National Institutes of Health
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Related topics
1 relation
shoc2 gene analysis
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
SHOC2 phosphatase-dependent RAF dimerization mediates resistance to MEK inhibition in RAS-mutant cancers
Greg G. Jones
,
Isabel Boned Del Río
,
+10 authors
P. Rodriguez-Viciana
Nature Communications
2019
Corpus ID: 182951072
Targeted inhibition of the ERK-MAPK pathway, upregulated in a majority of human cancers, has been hindered in the clinic by drug…
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2014
2014
HUWE1 Is a Molecular Link Controlling RAF-1 Activity Supported by the Shoc2 Scaffold
Eun Ryoung Jang
,
Ping Shi
,
+6 authors
E. Galperin
Molecular and Cellular Biology
2014
Corpus ID: 34248437
ABSTRACT Scaffold proteins play a critical role in controlling the activity of the extracellular signal-regulated kinase 1/2…
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Highly Cited
2013
Highly Cited
2013
An MRAS, SHOC2, and SCRIB complex coordinates ERK pathway activation with polarity and tumorigenic growth.
L. C. Young
,
N. Hartig
,
+12 authors
P. Rodriguez-Viciana
Molecular cell
2013
Corpus ID: 206988304
2012
2012
The space optical clocks project: Development of high-performance transportable and breadboard optical clocks and advanced subsystems
S. Schiller
,
A. Gorlitz
,
+28 authors
F. Levi
European Frequency and Time Forum
2012
Corpus ID: 25127826
The use of ultra-precise optical clocks in space (“master clocks”) will allow for a range of new applications in the fields of…
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Highly Cited
2010
Highly Cited
2010
The Scaffold Protein Shoc2/SUR-8 Accelerates the Interaction of Ras and Raf*
Rie Matsunaga-Udagawa
,
Y. Fujita
,
+6 authors
M. Matsuda
The Journal of Biological Chemistry
2010
Corpus ID: 205295307
Shoc2/SUR-8 positively regulates Ras/ERK MAP kinase signaling by serving as a scaffold for Ras and Raf. Here, we examined the…
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2010
2010
Ras and Calcium Signaling Pathways Converge at Raf1 via the Shoc2 Scaffold Protein
Sayaka Yoshiki
,
Rie Matsunaga-Udagawa
,
K. Aoki
,
Y. Kamioka
,
E. Kiyokawa
,
M. Matsuda
Molecular biology of the cell
2010
Corpus ID: 16715213
Activation of Raf1 at the plasma membrane requires not only Ras activation but also an increase in Ca2+ concentration or…
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2010
2010
Endothelial SUR-8 Acts in an ERK-Independent Pathway During Atrioventricular Cushion Development
J. Yi
,
Muyun Chen
,
+5 authors
R. Xu
Developmental dynamics : an official publication…
2010
Corpus ID: 19026457
SUR‐8, a conserved leucine‐rich repeats protein, was first identified as a positive regulator of Ras pathway in Caenorhabditis…
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Highly Cited
2009
Highly Cited
2009
Mutation in SHOC2 promotes aberrant protein N-myristoylation and underlies Noonan-like syndrome with loose anagen hair
V. Cordeddu
,
E. Di Schiavi
,
+28 authors
M. Tartaglia
Nature Genetics
2009
Corpus ID: 11476085
N-myristoylation is a common form of co-translational protein fatty acylation resulting from the attachment of myristate to a…
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Highly Cited
1999
Highly Cited
1999
Characterization of a novel Ras-binding protein Ce-FLI-1 comprising leucine-rich repeats and gelsolin-like domains.
M. Goshima
,
K. Kariya
,
+5 authors
T. Kataoka
Biochemical and biophysical research…
1999
Corpus ID: 44987283
Ras proteins are conserved from yeasts to mammals and implicated in regulation of the actin cytoskeleton. The flightless-1 (fli-1…
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Highly Cited
1998
Highly Cited
1998
SUR-8, a Conserved Ras-Binding Protein with Leucine-Rich Repeats, Positively Regulates Ras-Mediated Signaling in C. elegans
D. Sieburth
,
Qun Sun
,
Min Han
Cell
1998
Corpus ID: 13102676
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