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SHOC2 gene

Known as: KIAA0862, SHOC2 leucine-rich repeat scaffold protein, SUR8 
 
National Institutes of Health

Papers overview

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2014
2014
Noonan‐like syndrome with loose anagen hair (NS/LAH; OMIM 607721) is a developmental disorder clinically related to Noonan… Expand
2014
2014
ABSTRACT Scaffold proteins play a critical role in controlling the activity of the extracellular signal-regulated kinase 1/2… Expand
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Highly Cited
2013
Highly Cited
2013
SHOC2 is mutated in Noonan syndrome and plays a key role in the activation of the ERK-MAPK pathway, which is upregulated in the… Expand
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Highly Cited
2010
Highly Cited
2010
Shoc2/SUR-8 positively regulates Ras/ERK MAP kinase signaling by serving as a scaffold for Ras and Raf. Here, we examined the… Expand
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2010
2010
Activation of Raf1 at the plasma membrane requires not only Ras activation but also an increase in Ca2+ concentration or… Expand
2010
2010
SUR‐8, a conserved leucine‐rich repeats protein, was first identified as a positive regulator of Ras pathway in Caenorhabditis… Expand
Highly Cited
2009
Highly Cited
2009
N-myristoylation is a common form of co-translational protein fatty acylation resulting from the attachment of myristate to a… Expand
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2005
2005
Growth hormone (GH) and IGF-I play important roles in wound healing during intestinal injury and inflammation, but there is also… Expand
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Highly Cited
1999
Highly Cited
1999
Ras proteins are conserved from yeasts to mammals and implicated in regulation of the actin cytoskeleton. The flightless-1 (fli-1… Expand
Highly Cited
1998
Highly Cited
1998
We describe the identification and characterization of a novel gene, sur-8, that positively regulates Ras-mediated signal… Expand
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