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SHOC2 gene

Known as: KIAA0862, SHOC2 leucine-rich repeat scaffold protein, SUR8 
National Institutes of Health

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shoc2 gene analysis

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
SHOC2 phosphatase-dependent RAF dimerization mediates resistance to MEK inhibition in RAS-mutant cancers
Targeted inhibition of the ERK-MAPK pathway, upregulated in a majority of human cancers, has been hindered in the clinic by drug… 
2014
2014
HUWE1 Is a Molecular Link Controlling RAF-1 Activity Supported by the Shoc2 Scaffold
ABSTRACT Scaffold proteins play a critical role in controlling the activity of the extracellular signal-regulated kinase 1/2… 
Highly Cited
2013
Highly Cited
2013
An MRAS, SHOC2, and SCRIB complex coordinates ERK pathway activation with polarity and tumorigenic growth.
2012
2012
The space optical clocks project: Development of high-performance transportable and breadboard optical clocks and advanced subsystems
The use of ultra-precise optical clocks in space (“master clocks”) will allow for a range of new applications in the fields of… 
Highly Cited
2010
Highly Cited
2010
The Scaffold Protein Shoc2/SUR-8 Accelerates the Interaction of Ras and Raf*
Shoc2/SUR-8 positively regulates Ras/ERK MAP kinase signaling by serving as a scaffold for Ras and Raf. Here, we examined the… 
2010
2010
Ras and Calcium Signaling Pathways Converge at Raf1 via the Shoc2 Scaffold Protein
Activation of Raf1 at the plasma membrane requires not only Ras activation but also an increase in Ca2+ concentration or… 
2010
2010
Endothelial SUR-8 Acts in an ERK-Independent Pathway During Atrioventricular Cushion Development
  • J. Yi, Muyun Chen, R. Xu
  • Developmental dynamics : an official publication…
  • 2010
  • Corpus ID: 19026457
SUR‐8, a conserved leucine‐rich repeats protein, was first identified as a positive regulator of Ras pathway in Caenorhabditis… 
Highly Cited
2009
Highly Cited
2009
Mutation in SHOC2 promotes aberrant protein N-myristoylation and underlies Noonan-like syndrome with loose anagen hair
N-myristoylation is a common form of co-translational protein fatty acylation resulting from the attachment of myristate to a… 
Highly Cited
1999
Highly Cited
1999
Characterization of a novel Ras-binding protein Ce-FLI-1 comprising leucine-rich repeats and gelsolin-like domains.
Ras proteins are conserved from yeasts to mammals and implicated in regulation of the actin cytoskeleton. The flightless-1 (fli-1… 
Highly Cited
1998
Highly Cited
1998
SUR-8, a Conserved Ras-Binding Protein with Leucine-Rich Repeats, Positively Regulates Ras-Mediated Signaling in C. elegans
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