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SDHB gene
Known as:
SDH2, HOMOLOG OF
, iron-sulfur subunit of complex II
, SUCCINATE DEHYDROGENASE 2, S. CEREVISIAE, HOMOLOG OF
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This gene plays a role in electron transport in the mitochondria.
National Institutes of Health
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Related topics
Related topics
5 relations
Cell Respiration
Hereditary Paraganglioma
Hereditary Paraganglioma-Pheochromocytoma Syndrome
Oxidation-Reduction
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Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2010
Highly Cited
2010
SDHA is a tumor suppressor gene causing paraganglioma.
N. Burnichon
,
J. Briere
,
+11 authors
A. Gimenez-Roqueplo
Human Molecular Genetics
2010
Corpus ID: 17031471
Mitochondrial succinate-coenzyme Q reductase (complex II) consists of four subunits, SDHA, SDHB, SDHC and SDHD. Heterozygous…
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Highly Cited
2010
Highly Cited
2010
Tumor risks and genotype–phenotype–proteotype analysis in 358 patients with germline mutations in SDHB and SDHD
C. Ricketts
,
Julia R. Forman
,
+24 authors
E. Maher
Human Mutation
2010
Corpus ID: 22888808
Succinate dehydrogenase B (SDHB) and D (SDHD) subunit gene mutations predispose to adrenal and extraadrenal pheochromocytomas…
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Highly Cited
2010
Highly Cited
2010
Research resource: Transcriptional profiling reveals different pseudohypoxic signatures in SDHB and VHL-related pheochromocytomas.
E. López-Jiménez
,
G. Gómez-López
,
+21 authors
A. Cascón
Molecular Endocrinology
2010
Corpus ID: 11931679
The six major genes involved in hereditary susceptibility for pheochromocytoma (PCC)/paraganglioma (PGL) (RET, VHL, NF1, SDHB…
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Highly Cited
2008
Highly Cited
2008
Germline SDHB mutations and familial renal cell carcinoma.
C. Ricketts
,
E. Woodward
,
+4 authors
E. Maher
Journal of the National Cancer Institute
2008
Corpus ID: 24147195
Familial renal cell carcinoma (RCC) is a heterogeneous disorder that is most commonly caused by germline mutations in the VHL…
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Highly Cited
2006
Highly Cited
2006
High frequency of SDHB germline mutations in patients with malignant catecholamine-producing paragangliomas: implications for genetic testing.
F. M. Brouwers
,
G. Eisenhofer
,
+4 authors
K. Pacak
Journal of Clinical Endocrinology and Metabolism
2006
Corpus ID: 43308271
CONTEXT Adrenal and extraadrenal paragangliomas are tumors of chromaffin cells that are usually benign but that may also develop…
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Highly Cited
2004
Highly Cited
2004
Distinct clinical features of paraganglioma syndromes associated with SDHB and SDHD gene mutations.
H. Neumann
,
Christian Pawlu
,
+13 authors
C. Eng
Journal of the American Medical Association (JAMA…
2004
Corpus ID: 21673619
CONTEXT Germline mutations of the genes encoding succinate dehydrogenase subunits B (SDHB) and D (SDHD) predispose to…
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Highly Cited
2004
Highly Cited
2004
Early-onset renal cell carcinoma as a novel extraparaganglial component of SDHB-associated heritable paraganglioma.
Sakari Vanharanta
,
Mary Buchta
,
+15 authors
C. Eng
American Journal of Human Genetics
2004
Corpus ID: 15720860
Hereditary paraganglioma syndrome has recently been shown to be caused by germline heterozygous mutations in three (SDHB, SDHC…
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Highly Cited
2003
Highly Cited
2003
Mutations in the SDHB gene are associated with extra-adrenal and/or malignant phaeochromocytomas.
A. Gimenez-Roqueplo
,
J. Favier
,
+7 authors
X. Jeunemaître
Cancer Research
2003
Corpus ID: 6351762
Germ-line mutations in the genes encoding succinate dehydrogenase complex subunits B (SDHB) and D (SDHD) have been reported in…
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Highly Cited
2002
Highly Cited
2002
Prevalence of SDHB, SDHC, and SDHD germline mutations in clinic patients with head and neck paragangliomas
B. Baysal
,
J. E. Willett-Brozick
,
+9 authors
W. Rubinstein
Journal of Medical Genetics
2002
Corpus ID: 11926368
Background: Paragangliomas are rare and highly heritable tumours of neuroectodermal origin that often develop in the head and…
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Highly Cited
2001
Highly Cited
2001
Gene mutations in the succinate dehydrogenase subunit SDHB cause susceptibility to familial pheochromocytoma and to familial paraganglioma.
D. Astuti
,
F. Latif
,
+7 authors
E. Maher
American Journal of Human Genetics
2001
Corpus ID: 24592258
The pheochromocytomas are an important cause of secondary hypertension. Although pheochromocytoma susceptibility may be…
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