SD-208
National Institutes of Health
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BackgroundSprouting angiogenesis requires vascular endothelial proliferation, migration and morphogenesis. The process is…
Melanoma often metastasizes to bone where it is exposed to high concentrations of TGF-β. Constitutive Smad signaling occurs in…
Purpose. An early hallmark of preclinical diabetic retinopathy is thickening of the capillary basal lamina (BL). TGF-beta, a…
MDS is characterized by ineffective hematopoiesis that leads to peripheral cytopenias. Development of effective treatments has…
Transforming growth factor β (TGFβ) is a pleiotropic factor that regulates cell proliferation, angiogenesis, metastasis, and…
Transforming growth factor (TGF)-β is a multifunctional regulator of cell growth and differentiation with both pro- and anti…
Purpose: Transforming growth factor-β (TGF-β) suppresses tumor development by inhibiting cellular proliferation, inducing…
Transforming growth factor-β (TGFβ) is a major mediator of normal wound healing and of pathological conditions involving fibrosis…
The cytokine transforming growth factor (TGF)-β, by virtue of its immunosuppressive and promigratory properties, has become a…
Purpose: Transforming growth factors (TGFs) have pleiotropic biological effects on tumor cells and their environment. In multiple…