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SD-208

 
National Institutes of Health

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1 relation

Broader (1)

Pteridines

Papers overview

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2014
2014
Overexpression of smad7 blocks primary tumor growth and lung metastasis development in osteosarcoma.
PURPOSE Osteosarcoma is the main malignant primary bone tumor in children and adolescents for whom the prognosis remains poor… Expand
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2013
2013
Evaluation of antitumor activity of a TGF-beta receptor I inhibitor (SD-208) on human colon adenocarcinoma
BackgroundTransforming growth factor-β (TGF-β) pathway is involved in primary tumor progression and in promoting metastasis in a… Expand
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Highly Cited
2011
Highly Cited
2011
TGF-beta-RI kinase inhibitor SD-208 reduces the development and progression of melanoma bone metastases.
Melanoma often metastasizes to bone where it is exposed to high concentrations of TGF-β. Constitutive Smad signaling occurs in… Expand
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2011
2011
Transforming growth factor-beta type 1 receptor (ALK5) and Smad proteins mediate TIMP-1 and collagen synthesis in experimental intestinal fibrosis.
Transforming growth factor β (TGF-β) is known to play a key role in intestinal fibrosis; however, the underlying mechanisms are… Expand
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Highly Cited
2008
Highly Cited
2008
Inhibition of the TGF-beta receptor I kinase promotes hematopoiesis in MDS.
MDS is characterized by ineffective hematopoiesis that leads to peripheral cytopenias. Development of effective treatments has… Expand
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2008
2008
Transforming growth factor-beta blockade down-regulates the renin-angiotensin system and modifies cardiac remodeling after myocardial infarction.
After myocardial infarction (MI), the heart may undergo progressive ventricular remodeling, resulting in a deterioration of… Expand
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Highly Cited
2007
Highly Cited
2007
Inhibition of transforming growth factor beta signaling reduces pancreatic adenocarcinoma growth and invasiveness.
Transforming growth factor beta (TGFbeta) is a pleiotropic factor that regulates cell proliferation, angiogenesis, metastasis… Expand
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2006
2006
Effect of transforming growth factor-beta receptor I kinase inhibitor 2,4-disubstituted pteridine (SD-208) in chronic allergic airway inflammation and remodeling.
Transforming growth factor (TGF)-beta is a multifunctional regulator of cell growth and differentiation with both pro- and anti… Expand
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Highly Cited
2006
Highly Cited
2006
Inhibition of growth and metastasis of mouse mammary carcinoma by selective inhibitor of transforming growth factor-beta type I receptor kinase in vivo.
PURPOSE Transforming growth factor-beta (TGF-beta) suppresses tumor development by inhibiting cellular proliferation, inducing… Expand
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Highly Cited
2004
Highly Cited
2004
SD-208, a novel transforming growth factor beta receptor I kinase inhibitor, inhibits growth and invasiveness and enhances immunogenicity of murine and human glioma cells in vitro and in vivo.
The cytokine transforming growth factor (TGF)-beta, by virtue of its immunosuppressive and promigratory properties, has become a… Expand
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