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SD-208

 

Topic mentions per year

Topic mentions per year

2004-2015
02420042015

Related topics

Related topics

1 relation

Broader (1)

Pteridines

Related mentions per year

Related mentions per year

1947-2018
19401960198020002020
SD-208
Pteridines

Papers overview

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2015
2015
Down-regulation of miR-135b in colon adenocarcinoma induced by a TGF-β receptor I kinase inhibitor (SD-208)
OBJECTIVES Transforming growth factor-β (TGF-β) is involved in colorectal cancer (CRC). The SD-208 acts as an anti-cancer agent… (More)
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2013
2013
Evaluation of antitumor activity of a TGF-beta receptor I inhibitor (SD-208) on human colon adenocarcinoma
Transforming growth factor-β (TGF-β) pathway is involved in primary tumor progression and in promoting metastasis in a… (More)
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Highly Cited
2011
Highly Cited
2011
TGF-beta-RI kinase inhibitor SD-208 reduces the development and progression of melanoma bone metastases.
Melanoma often metastasizes to bone where it is exposed to high concentrations of TGF-β. Constitutive Smad signaling occurs in… (More)
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2008
2008
Inhibition of the TGF-beta receptor I kinase promotes hematopoiesis in MDS.
MDS is characterized by ineffective hematopoiesis that leads to peripheral cytopenias. Development of effective treatments has… (More)
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2008
2008
Role of the TGF-beta/Alk5 signaling pathway in monocrotaline-induced pulmonary hypertension.
RATIONALE Pulmonary arterial hypertension is a progressive disease characterized by an elevation in the mean pulmonary artery… (More)
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2007
2007
Inhibition of transforming growth factor beta signaling reduces pancreatic adenocarcinoma growth and invasiveness.
Transforming growth factor beta (TGFbeta) is a pleiotropic factor that regulates cell proliferation, angiogenesis, metastasis… (More)
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2006
2006
Effect of transforming growth factor-beta receptor I kinase inhibitor 2,4-disubstituted pteridine (SD-208) in chronic allergic airway inflammation and remodeling.
Transforming growth factor (TGF)-beta is a multifunctional regulator of cell growth and differentiation with both pro- and anti… (More)
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Highly Cited
2006
Highly Cited
2006
Inhibition of growth and metastasis of mouse mammary carcinoma by selective inhibitor of transforming growth factor-beta type I receptor kinase in vivo.
PURPOSE Transforming growth factor-beta (TGF-beta) suppresses tumor development by inhibiting cellular proliferation, inducing… (More)
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Highly Cited
2004
Highly Cited
2004
SD-208, a novel transforming growth factor beta receptor I kinase inhibitor, inhibits growth and invasiveness and enhances immunogenicity of murine and human glioma cells in vitro and in vivo.
The cytokine transforming growth factor (TGF)-beta, by virtue of its immunosuppressive and promigratory properties, has become a… (More)
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2004
2004
Transforming growth factor beta receptor I kinase inhibitor down-regulates cytokine secretion and multiple myeloma cell growth in the bone marrow microenvironment.
PURPOSE Transforming growth factors (TGFs) have pleiotropic biological effects on tumor cells and their environment. In multiple… (More)
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