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SD-208

 
National Institutes of Health

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1 relation

Broader (1)

Pteridines

Papers overview

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Highly Cited
2011
Highly Cited
2011
TGF-beta-RI kinase inhibitor SD-208 reduces the development and progression of melanoma bone metastases.
Melanoma often metastasizes to bone where it is exposed to high concentrations of TGF-β. Constitutive Smad signaling occurs in… Expand
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Highly Cited
2011
Highly Cited
2011
Transforming growth factor‐beta type 1 receptor (ALK5) and Smad proteins mediate TIMP‐1 and collagen synthesis in experimental intestinal fibrosis
Transforming growth factor β (TGF‐β) is known to play a key role in intestinal fibrosis; however, the underlying mechanisms are… Expand
Highly Cited
2008
Highly Cited
2008
Inhibition of the TGF-beta receptor I kinase promotes hematopoiesis in MDS.
MDS is characterized by ineffective hematopoiesis that leads to peripheral cytopenias. Development of effective treatments has… Expand
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Highly Cited
2008
Highly Cited
2008
Transforming growth factor-beta blockade down-regulates the renin-angiotensin system and modifies cardiac remodeling after myocardial infarction.
After myocardial infarction (MI), the heart may undergo progressive ventricular remodeling, resulting in a deterioration of… Expand
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Highly Cited
2007
Highly Cited
2007
Inhibition of Transforming Growth Factor β Signaling Reduces Pancreatic Adenocarcinoma Growth and Invasiveness
Transforming growth factor β (TGFβ) is a pleiotropic factor that regulates cell proliferation, angiogenesis, metastasis, and… Expand
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Highly Cited
2006
Highly Cited
2006
Effect of Transforming Growth Factor-β Receptor I Kinase Inhibitor 2,4-Disubstituted Pteridine (SD-208) in Chronic Allergic Airway Inflammation and Remodeling
Transforming growth factor (TGF)-β is a multifunctional regulator of cell growth and differentiation with both pro- and anti… Expand
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Highly Cited
2006
Highly Cited
2006
Inhibition of Growth and Metastasis of Mouse Mammary Carcinoma by Selective Inhibitor of Transforming Growth Factor-β Type I Receptor Kinase In vivo
Purpose: Transforming growth factor-β (TGF-β) suppresses tumor development by inhibiting cellular proliferation, inducing… Expand
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Highly Cited
2006
Highly Cited
2006
Transforming Growth Factor-β Receptor Type 1 (TGFβRI) Kinase Activity but Not p38 Activation Is Required for TGFβRI-Induced Myofibroblast Differentiation and Profibrotic Gene Expression
Transforming growth factor-β (TGFβ) is a major mediator of normal wound healing and of pathological conditions involving fibrosis… Expand
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Highly Cited
2004
Highly Cited
2004
SD-208, a Novel Transforming Growth Factor β Receptor I Kinase Inhibitor, Inhibits Growth and Invasiveness and Enhances Immunogenicity of Murine and Human Glioma Cells In vitro and In vivo
The cytokine transforming growth factor (TGF)-β, by virtue of its immunosuppressive and promigratory properties, has become a… Expand
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Highly Cited
2004
Highly Cited
2004
Transforming Growth Factor β Receptor I Kinase Inhibitor Down-Regulates Cytokine Secretion and Multiple Myeloma Cell Growth in the Bone Marrow Microenvironment
Purpose: Transforming growth factors (TGFs) have pleiotropic biological effects on tumor cells and their environment. In multiple… Expand
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