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SCID-Repopulating Cell

Known as: SRC, SCID Repopulating Cell, Severe Combined Immunodeficient Repopulating Cell 
A human hematopoietic stem cell that is able to repopulate the hematopoietic system of non-obese diabetic/severe combined immunodeficient mice (NOD… 
National Institutes of Health

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Hematopoietic and Lymphoid TissueHemopoietic tissue

Papers overview

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Highly Cited
2014
Highly Cited
2014
Impaired neurovascular unit function contributes to persistent symptoms after concussion: a pilot study.
Research shows that approximately 14% of school age children with mild traumatic brain injury (TBI) including sports-related… 
Highly Cited
2011
Highly Cited
2011
H2S-Induced Sulfhydration of the Phosphatase PTP1B and Its Role in the Endoplasmic Reticulum Stress Response
Reversible inactivation by sulfhydration of the protein tyrosine phosphatase PTP1B activates the kinase PERK to promote the ER… 
Highly Cited
2005
Highly Cited
2005
Rapid mobilization of murine and human hematopoietic stem and progenitor cells with AMD3100, a CXCR4 antagonist
Improving approaches for hematopoietic stem cell (HSC) and hematopoietic progenitor cell (HPC) mobilization is clinically… 
Highly Cited
2003
Highly Cited
2003
Lentiviral vector transduction of NOD/SCID repopulating cells results in multiple vector integrations per transduced cell: risk of insertional mutagenesis.
Efficient vector transduction of hematopoietic stem cells is a requirement for successful gene therapy of hematologic disorders… 
Highly Cited
2003
Highly Cited
2003
SCID-repopulating cell activity of human cord blood-derived CD34- cells assured by intra-bone marrow injection.
Precise analysis of human CD34-negative (CD34(-)) hematopoietic stem cells (HSCs) has been hindered by the lack of a simple and… 
Highly Cited
2000
Highly Cited
2000
Expansion of human cord blood CD34(+)CD38(-) cells in ex vivo culture during retroviral transduction without a corresponding increase in SCID repopulating cell (SRC) frequency: dissociation of SRC…
Current procedures for the genetic manipulation of hematopoietic stem cells are relatively inefficient due, in part, to a poor… 
Highly Cited
1998
Highly Cited
1998
The Steroid Receptor Coactivator-1 Contains Multiple Receptor Interacting and Activation Domains That Cooperatively Enhance the Activation Function 1 (AF1) and AF2 Domains of Steroid Receptors*
Steroid receptors are ligand-inducible transcription factors, and their association with steroid receptor coactivators (SRCs… 
Highly Cited
1998
Highly Cited
1998
Ligand-independent recruitment of steroid receptor coactivators to estrogen receptor by cyclin D1.
The estrogen receptor (ER) is an important regulator of growth and differentiation of breast epithelium. Transactivation by ER… 
Highly Cited
1997
Highly Cited
1997
Primitive human hematopoietic cells are enriched in cord blood compared with adult bone marrow or mobilized peripheral blood as measured by the quantitative in vivo SCID-repopulating cell assay.
We have previously reported the development of in vivo functional assays for primitive human hematopoietic cells based on their… 
Highly Cited
1996
Highly Cited
1996
Identification of primitive human hematopoietic cells capable of repopulating NOD/SCID mouse bone marrow: Implications for gene therapy
The development of stem–cell gene therapy is hindered by the absence of repopulation assays for primitive human hematopoietic… 
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