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SCH 527123

Known as: SCH-527123, SCH527123 
National Institutes of Health

Papers overview

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2016
2016
A1.16 Role of IL-8 and its receptor in anti-citrullinated protein antibody mediated osteoclastogenesis in ra
Background and objectives Circulating levels of IL-8 is related to the bone loss associated with breast cancer metastasis… 
2014
2014
Abstract 4874: CXCR2 signaling axis- a helping hand to KRAS(G12D) mutation in pancreatic cancer initiation
Pancreatic cancer (PC) is the fourth leading cause of cancer-related deaths in the United States. The high mortality can be… 
2012
2012
The CXCR2 antagonist, SCH-527123, demonstrates antitumor activity and sensitizes cells to oxaliplatin in preclinical colon cancer models
Colorectal cancer (CRC) is the second most common cause of cancer-related death in the United States. Recent studies showed that… 
2012
2012
Preclinical Development The CXCR 2 Antagonist , SCH-527123 , Shows Antitumor Activity andSensitizesCells toOxaliplatin inPreclinical Colon Cancer Models
Colorectal cancer is the second most common cause of cancer-related death in the United States. Recent studies showed that… 
2010
2010
Safety and efficacy of SCH527123, a novel CXCR2 antagonist, in patients with COPD
2010
2010
SCH527123, a Novel Treatment Option For Severe Neutrophilic Asthma
Results: 22 patients received active treatment (13 female, mean age 48.7, median ICS dose 1738mcg, median OCS dose 11.7mg/day… 
2010
2010
Treatment With The CXCR2 Antagonist SCH527123 Reduced Neutrophil Levels In Blood And Airways But Not Bone Marrow In Mild Asthmatic Subjects
Review
2010
Review
2010
Discovery of 3,4-diaminocyclobut-3-ene-1,2-dione-based CXCR2 receptor antagonists for the treatment of inflammatory disorders.
The CXC chemokine receptor 2 (CXCR2) has attracted a considerable amount of attention as a target for therapeutic intervention… 
2009
2009
CXCR2 Inverse Agonism Detected by Arrestin Redistribution
To study CXCR2 modulated arrestin redistribution, the authors employed arrestin as a fusion protein containing either the… 
2007
2007
Pharmacological Characterization of Sch 527123 , a Potent Allosteric CXCR 1 / CXCR 2 Antagonist
In neutrophils, growth-related protein(CXCL1) and interleukin-8 (CXCL8), are potent chemoattractants (Cytokine 14:27– 36, 2001… 
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