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SCH 527123

Known as: SCH-527123, SCH527123 
 
National Institutes of Health

Papers overview

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Review
2015
Review
2015
Neutrophil infiltration and activation in the lung are important pathophysiological features in COPD, severe asthma and… Expand
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Highly Cited
2013
Highly Cited
2013
Alveolar macrophages produce neutrophil chemoattractants; this cellular cross-talk contributes to neutrophilic airway… Expand
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Highly Cited
2012
Highly Cited
2012
Colorectal cancer is the second most common cause of cancer-related death in the United States. Recent studies showed that… Expand
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Highly Cited
2012
Highly Cited
2012
BACKGROUND Increased numbers of neutrophils are reported in the airways of patients with severe asthma. It is not clear if they… Expand
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Highly Cited
2011
Highly Cited
2011
CXCR1 and CXCR2 are G-protein coupled receptors, that have been shown to play important role in tumor growth and metastasis, and… Expand
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Highly Cited
2010
Highly Cited
2010
BACKGROUND AND PURPOSE We have previously shown that SB265610 (1-(2-bromo-phenyl)-3-(7-cyano-3H-benzotriazol-4-yl)-urea) behaves… Expand
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Highly Cited
2009
Highly Cited
2009
SCH527123 is a novel, selective CXC chemokine receptor 2 antagonist that inhibits neutrophil activation and modulates neutrophil… Expand
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Highly Cited
2009
Highly Cited
2009
Purpose: Melanoma, the most aggressive form of skin cancer, accounts for 75% of all skin cancer-related deaths and current… Expand
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Highly Cited
2007
Highly Cited
2007
Sch527123 [2-hydroxy-N,N-dimethyl-3-[[2-[[1(R)-(5-methyl-2-furanyl)propyl]amino]-3,4-dioxo-1-cyclobuten-1-yl]amino]ben-zamide] is… Expand
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Highly Cited
2006
Highly Cited
2006
Structure-activity studies on lead cyclobutenedione 3 led to the discovery of 4 (SCH 527123), a potent, orally bioavailable CXCR2… Expand
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