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SCH 48461
Known as:
SCH-48461
National Institutes of Health
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Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Review
2003
Review
2003
Ezetimibe for Management of Hypercholesterolemia
V. F. Mauro
,
Chad E Tuckerman
The Annals of pharmacotherapy
2003
Corpus ID: 23228426
OBJECTIVE: To review the primary literature describing the pharmacology of ezetimibe and clinical trials investigating its use in…
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Highly Cited
2002
Highly Cited
2002
Inhibition of cholesterol absorption by SCH 58053 in the mouse is not mediated via changes in the expression of mRNA for ABCA1, ABCG5, or ABCG8 in the enterocyte Published, JLR Papers in Press…
J. Repa
,
J. Dietschy
,
S. Turley
Journal of Lipid Research
2002
Corpus ID: 23300227
Intestinal cholesterol absorption is a major determinant of plasma low density lipoprotein-cholesterol (LDL-C) concentrations…
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Highly Cited
2001
Highly Cited
2001
The synergistic hypocholesterolemic activity of the potent cholesterol absorption inhibitor, ezetimibe, in combination with 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitors in dogs.
H. Davis
,
K. Pula
,
K. Alton
,
R. Burrier
,
R. Watkins
Metabolism: clinical and experimental
2001
Corpus ID: 25107888
Ezetimibe (SCH 58235) and SCH 48461 are potent cholesterol absorption inhibitors, which cause significant decreases in plasma…
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2001
2001
Reduction of LDL Cholesterol in Patients with Primary Hypercholesterolemia by SCH 48461: Results of a Multicenter Dose‐Ranging Study
C. Dujovne
,
H. Bays
,
+7 authors
C. Cuffie-Jackson
Journal of clinical pharmacology
2001
Corpus ID: 30737100
SCH 48461, an inhibitor of gastrointestinal absorption of cholesterol, was evaluated for its effects on lipid parameters in…
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Highly Cited
1998
Highly Cited
1998
Discovery of 1-(4-fluorophenyl)-(3R)-[3-(4-fluorophenyl)-(3S)-hydroxypropyl]-(4S)-(4 -hydroxyphenyl)-2-azetidinone (SCH 58235): a designed, potent, orally active inhibitor of cholesterol absorption.
S. Rosenblum
,
T. Huynh
,
+4 authors
D. A. Burnett
Journal of medicinal chemistry
1998
Corpus ID: 25526253
(3R)-(3-Phenylpropyl)-1,(4S)-bis(4-methoxyphenyl)-2-azetidinone (2, SCH 48461), a novel inhibitor of intestinal cholesterol…
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1997
1997
Spectroscopic identification of an amorphous-to-crystalline drug transition in a solid dispersion SCH 48461 capsule formulation.
R. Markovich
,
C. A. Evans
,
C. Coscolluela
,
S. Zibas
,
J. Rosen
Journal of pharmaceutical and biomedical analysis
1997
Corpus ID: 26115287
Highly Cited
1996
Highly Cited
1996
2-Azetidinone cholesterol absorption inhibitors: structure-activity relationships on the heterocyclic nucleus.
J. Clader
,
D. Burnett
,
+9 authors
H. Davis
Journal of medicinal chemistry
1996
Corpus ID: 19259252
A series of azetidinone cholesterol absorption inhibitors related to SCH 48461 ((-)-6) has been prepared, and compounds were…
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Highly Cited
1995
Highly Cited
1995
Hypocholesterolemic activity of a novel inhibitor of cholesterol absorption, SCH 48461.
B. Salisbury
,
H. Davis
,
+7 authors
D. G. McGregor
Atherosclerosis
1995
Corpus ID: 35702163
1995
1995
Substituted 2-azaspiro[5.3]nonan-1-ones as potent cholesterol absorption inhibitors: defining a binding conformation for SCH 48461.
S. Dugar
,
J. Clader
,
T. Chan
,
H. Davis
Journal of medicinal chemistry
1995
Corpus ID: 9493006
1994
1994
SCH 48461, a novel inhibitor of cholesterol absorption
E. Sybertz
,
H. Davis
,
B. Salisbury
,
R. Burrier
,
J. Clader
,
D. Burnett
1994
Corpus ID: 72093673
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