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SCH 48461

Known as: SCH-48461 
 
National Institutes of Health

Topic mentions per year

Topic mentions per year

1995-2004
012319952004

Papers overview

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Review
2004
Review
2004
Beta-lactam cholesterol absorption inhibitors.
beta-Lactams have recently been identified as potent, highly efficacious cholesterol absorption inhibitors (CAIs). The discovery… (More)
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2002
2002
Inhibition of cholesterol absorption by SCH 58053 in the mouse is not mediated via changes in the expression of mRNA for ABCA1, ABCG5, or ABCG8 in the enterocyte.
Intestinal cholesterol absorption is a major determinant of plasma low density lipoprotein-cholesterol (LDL-C) concentrations… (More)
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2002
2002
Synthesis of iodinated biochemical tools related to the 2-azetidinone class of cholesterol absorption inhibitors.
The discoveries of Sch 48461 and Sch 58235 and their novel pharmacology of inhibition of cholesterol absorption have prompted… (More)
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2001
2001
Reduction of LDL cholesterol in patients with primary hypercholesterolemia by SCH 48461: results of a multicenter dose-ranging study.
SCH 48461, an inhibitor of gastrointestinal absorption of cholesterol, was evaluated for its effects on lipid parameters in… (More)
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2001
2001
The synergistic hypocholesterolemic activity of the potent cholesterol absorption inhibitor, ezetimibe, in combination with 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitors in dogs.
Ezetimibe (SCH 58235) and SCH 48461 are potent cholesterol absorption inhibitors, which cause significant decreases in plasma… (More)
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2001
2001
Conformational and temperature effects on separation of stereoisomers of a C3,C4-substituted beta-lactamic cholesterol absorption inhibitor on amylose-based chiral stationary phases.
A direct liquid chromatography method was developed for the diastereo- and enantioselective analysis of a C3,C4-substituted beta… (More)
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1996
1996
2-Azetidinone cholesterol absorption inhibitors: structure-activity relationships on the heterocyclic nucleus.
A series of azetidinone cholesterol absorption inhibitors related to SCH 48461 ((-)-6) has been prepared, and compounds were… (More)
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1995
1995
Hypocholesterolemic activity of a novel inhibitor of cholesterol absorption, SCH 48461.
The amount of cholesterol that circulates in the plasma as lipoproteins can be affected by the balance of cholesterol metabolism… (More)
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1995
1995
Substituted 2-azaspiro[5.3]nonan-1-ones as potent cholesterol absorption inhibitors: defining a binding conformation for SCH 48461.
 
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