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SC 435

Known as: SC-435, SC435 
 
National Institutes of Health

Papers overview

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Highly Cited
2016
Highly Cited
2016
Pharmacological inhibition of apical sodium‐dependent bile acid transporter changes bile composition and blocks progression of sclerosing cholangitis in multidrug resistance 2 knockout mice
Deficiency of multidrug resistance 2 (mdr2), a canalicular phospholipid floppase, leads to excretion of low‐phospholipid “toxic… Expand
2011
2011
Active Transport of Bile Acids Decreases Mucin 2 in Neonatal Ileum: Implications for Development of Necrotizing Enterocolitis
Necrotizing enterocolitis (NEC) is the most common gastrointestinal emergency of premature infants, but its etiology remains… Expand
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Highly Cited
2010
Highly Cited
2010
Colesevelam improves insulin resistance in a diet-induced obesity (F-DIO) rat model by increasing the release of GLP-1.
Bile acid sequestrants have been shown to lower glucose levels in patients with type 2 diabetes. To investigate how colesevelam… Expand
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2008
2008
Inhibition of intestinal absorption of cholesterol by ezetimibe or bile acids by SC-435 alters lipoprotein metabolism and extends the lifespan of SR-BI/apoE double knockout mice.
SR-BI/apoE double knockout (dKO) mice exhibit many features of human coronary heart disease (CHD), including hypercholesterolemia… Expand
2005
2005
SC-435, an ileal apical sodium-codependent bile acid transporter inhibitor alters mRNA levels and enzyme activities of selected genes involved in hepatic cholesterol and lipoprotein metabolism in…
We have demonstrated that SC-435, an apical sodium codependent bile acid transporter (ASBT) inhibitor, lowers plasma low-density… Expand
Highly Cited
2005
Highly Cited
2005
FXR-activating ligands inhibit rabbit ASBT expression via FXR-SHP-FTF cascade.
  • Hai Li, Frank Chen, +8 authors G. Xu
  • American journal of physiology. Gastrointestinal…
  • 2005
    • Corpus ID: 16134395
The regulation of the rabbit apical sodium-dependent bile acid transporter (ASBT) was studied both in vivo and in vitro. New… Expand
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Highly Cited
2004
Highly Cited
2004
Inhibition of ileal bile acid transport lowers plasma cholesterol levels by inactivating hepatic farnesoid X receptor and stimulating cholesterol 7 alpha-hydroxylase.
  • H. Li, G. Xu, +7 authors G. Salen
  • Metabolism: clinical and experimental
  • 2004
    • Corpus ID: 42736469
We investigated the effect of SC-435, a competitive inhibitor of ileal apical sodium-dependent bile acid cotransporter (ASBT) on… Expand
Highly Cited
2003
Highly Cited
2003
Inhibition of ileal bile acid transport and reduced atherosclerosis in apoE−/− mice by SC-435 Published, JLR Papers in Press, June 16, 2003. DOI 10.1194/jlr.M200469-JLR200
Blocking intestinal bile acid absorption by inhibiting the apical sodium codependent bile acid transporter (ASBT) is a target for… Expand
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2002
2002
1-[4-[4[(4R,5R)-3,3-Dibutyl-7-(dimethylamino)-2,3,4,5-tetrahydro-4-hydroxy-1,1-dioxido-1-benzothiepin-5-yl]phenoxy]butyl]-4-aza-1-azoniabicyclo[2.2.2]octane Methanesulfonate (SC-435), an Ileal Apical…
Male Hartley guinea pigs (10/group) were assigned either to a control diet (no drug treatment) or to diets containing 0.4, 2.2… Expand
Highly Cited
2002
Highly Cited
2002
Inhibition of the Apical Sodium-Dependent Bile Acid Transporter Reduces LDL Cholesterol and ApoB by Enhanced Plasma Clearance of LDL ApoB
Objective—Cloning of the ileal apical sodium-dependent bile acid transporter (ASBT) has identified a new pharmacological target… Expand
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