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SC 435
Known as:
SC-435
, SC435
National Institutes of Health
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2018
2018
Dysregulated bile acid signaling contributes to the neurological impairment in murine models of acute and chronic liver failure
G. Xie
,
Xiaoning Wang
,
+13 authors
Wei Jia
EBioMedicine
2018
Corpus ID: 53043310
Highly Cited
2016
Highly Cited
2016
Pharmacological inhibition of apical sodium‐dependent bile acid transporter changes bile composition and blocks progression of sclerosing cholangitis in multidrug resistance 2 knockout mice
A. Miethke
,
Wujuan Zhang
,
+10 authors
K. Setchell
Hepatology
2016
Corpus ID: 205897772
Deficiency of multidrug resistance 2 (mdr2), a canalicular phospholipid floppase, leads to excretion of low‐phospholipid “toxic…
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2011
2011
Active Transport of Bile Acids Decreases Mucin 2 in Neonatal Ileum: Implications for Development of Necrotizing Enterocolitis
Nina A. Martin
,
Sarah K Mount Patrick
,
+4 authors
M. Halpern
PLoS ONE
2011
Corpus ID: 283561
Necrotizing enterocolitis (NEC) is the most common gastrointestinal emergency of premature infants, but its etiology remains…
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Highly Cited
2010
Highly Cited
2010
Colesevelam improves insulin resistance in a diet-induced obesity (F-DIO) rat model by increasing the release of GLP-1.
Q. Shang
,
Monica Saumoy
,
J. Holst
,
G. Salen
,
Guorong Xu
American Journal of Physiology - Gastrointestinal…
2010
Corpus ID: 10835620
Bile acid sequestrants have been shown to lower glucose levels in patients with type 2 diabetes. To investigate how colesevelam…
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2010
2010
Apical sodium-dependent bile acid transporter upregulation is associated with necrotizing enterocolitis.
M. Halpern
,
J. Weitkamp
,
+4 authors
B. Dvořák
American Journal of Physiology - Gastrointestinal…
2010
Corpus ID: 15248465
Necrotizing enterocolitis (NEC) is the most common gastrointestinal emergency of premature infants. Previously, we showed that…
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Highly Cited
2005
Highly Cited
2005
FXR-activating ligands inhibit rabbit ASBT expression via FXR-SHP-FTF cascade.
Hai Li
,
Frank Chen
,
+8 authors
Guorong Xu
American Journal of Physiology - Gastrointestinal…
2005
Corpus ID: 16134395
The regulation of the rabbit apical sodium-dependent bile acid transporter (ASBT) was studied both in vivo and in vitro. New…
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Highly Cited
2004
Highly Cited
2004
Inhibition of ileal bile acid transport lowers plasma cholesterol levels by inactivating hepatic farnesoid X receptor and stimulating cholesterol 7 alpha-hydroxylase.
Hai Li
,
Guorong Xu
,
+7 authors
G. Salen
Metabolism: Clinical and Experimental
2004
Corpus ID: 42736469
Highly Cited
2003
Highly Cited
2003
Inhibition of ileal bile acid transport and reduced atherosclerosis in apoE−/− mice by SC-435 Published, JLR Papers in Press, June 16, 2003. DOI 10.1194/jlr.M200469-JLR200
B. Bhat
,
S. Rapp
,
+6 authors
B. Keller
Journal of Lipid Research
2003
Corpus ID: 14952479
Blocking intestinal bile acid absorption by inhibiting the apical sodium codependent bile acid transporter (ASBT) is a target for…
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2002
2002
1-[4-[4[(4R,5R)-3,3-Dibutyl-7-(dimethylamino)-2,3,4,5-tetrahydro-4-hydroxy-1,1-dioxido-1-benzothiepin-5-yl]phenoxy]butyl]-4-aza-1-azoniabicyclo[2.2.2]octane Methanesulfonate (SC-435), an Ileal Apical…
K. West
,
T. Ramjiganesh
,
Suheeta Roy
,
B. Keller
,
M. Fernández
Journal of Pharmacology and Experimental…
2002
Corpus ID: 12163646
Male Hartley guinea pigs (10/group) were assigned either to a control diet (no drug treatment) or to diets containing 0.4, 2.2…
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Highly Cited
2002
Highly Cited
2002
Inhibition of the Apical Sodium-Dependent Bile Acid Transporter Reduces LDL Cholesterol and ApoB by Enhanced Plasma Clearance of LDL ApoB
M. Huff
,
D. E. Telford
,
+5 authors
B. Keller
Arteriosclerosis, Thrombosis and Vascular Biology
2002
Corpus ID: 5708109
Objective—Cloning of the ileal apical sodium-dependent bile acid transporter (ASBT) has identified a new pharmacological target…
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