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SC 435

Known as: SC-435, SC435 
National Institutes of Health

Papers overview

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2018
2018
Dysregulated bile acid signaling contributes to the neurological impairment in murine models of acute and chronic liver failure
Highly Cited
2016
Highly Cited
2016
Pharmacological inhibition of apical sodium‐dependent bile acid transporter changes bile composition and blocks progression of sclerosing cholangitis in multidrug resistance 2 knockout mice
Deficiency of multidrug resistance 2 (mdr2), a canalicular phospholipid floppase, leads to excretion of low‐phospholipid “toxic… 
2011
2011
Active Transport of Bile Acids Decreases Mucin 2 in Neonatal Ileum: Implications for Development of Necrotizing Enterocolitis
Necrotizing enterocolitis (NEC) is the most common gastrointestinal emergency of premature infants, but its etiology remains… 
Highly Cited
2010
Highly Cited
2010
Colesevelam improves insulin resistance in a diet-induced obesity (F-DIO) rat model by increasing the release of GLP-1.
Bile acid sequestrants have been shown to lower glucose levels in patients with type 2 diabetes. To investigate how colesevelam… 
2010
2010
Apical sodium-dependent bile acid transporter upregulation is associated with necrotizing enterocolitis.
Necrotizing enterocolitis (NEC) is the most common gastrointestinal emergency of premature infants. Previously, we showed that… 
Highly Cited
2005
Highly Cited
2005
FXR-activating ligands inhibit rabbit ASBT expression via FXR-SHP-FTF cascade.
The regulation of the rabbit apical sodium-dependent bile acid transporter (ASBT) was studied both in vivo and in vitro. New… 
Highly Cited
2004
Highly Cited
2004
Inhibition of ileal bile acid transport lowers plasma cholesterol levels by inactivating hepatic farnesoid X receptor and stimulating cholesterol 7 alpha-hydroxylase.
Highly Cited
2003
Highly Cited
2003
Inhibition of ileal bile acid transport and reduced atherosclerosis in apoE−/− mice by SC-435 Published, JLR Papers in Press, June 16, 2003. DOI 10.1194/jlr.M200469-JLR200
Blocking intestinal bile acid absorption by inhibiting the apical sodium codependent bile acid transporter (ASBT) is a target for… 
2002
2002
1-[4-[4[(4R,5R)-3,3-Dibutyl-7-(dimethylamino)-2,3,4,5-tetrahydro-4-hydroxy-1,1-dioxido-1-benzothiepin-5-yl]phenoxy]butyl]-4-aza-1-azoniabicyclo[2.2.2]octane Methanesulfonate (SC-435), an Ileal Apical…
Male Hartley guinea pigs (10/group) were assigned either to a control diet (no drug treatment) or to diets containing 0.4, 2.2… 
Highly Cited
2002
Highly Cited
2002
Inhibition of the Apical Sodium-Dependent Bile Acid Transporter Reduces LDL Cholesterol and ApoB by Enhanced Plasma Clearance of LDL ApoB
Objective—Cloning of the ileal apical sodium-dependent bile acid transporter (ASBT) has identified a new pharmacological target… 
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