SC-2001
National Institutes of Health
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MCL-1 (BCL-2 family anti-apoptotic protein) is responsible for melanoma's resistance to therapy. Cancer initiating cells also…
Interfering oncogenic STAT3 signaling is a promising anti-cancer strategy. We examined the efficacy and drug mechanism of an…
Obatoclax is a small molecule which targets the Bcl-2 family, and is to treat leukemia, lymphoma and lung carcinoma. Previously…
Interfering oncogenic STAT3 signaling is a promising anti-cancer strategy. We examined the efficacy and drug mechanism of an…
Proceedings: AACR Annual Meeting 2014; April 5-9, 2014; San Diego, CA
Background: Interfering the oncogenic STAT3 signaling is…
Proceedings: AACR Annual Meeting 2014; April 5-9, 2014; San Diego, CA
Obatoclax is under clinical trial currently. Previously…
Background: STAT3 has been shown to play an important role in breast carcinogenesis and is often overexpressed in primary breast…
Proceedings: AACR 102nd Annual Meeting 2011‐‐ Apr 2‐6, 2011; Orlando, FL
The activation of signal transducers and activators of…