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SB 649868

Known as: SB-649868, SB649868 
 
National Institutes of Health

Papers overview

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Highly Cited
2014
Highly Cited
2014
In accordance with the prominent role of orexins in the maintenance of wakefulness via activation of orexin-1 (OX1R) and orexin-2… Expand
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2014
2014
RationaleThe orexin-hypocretin system is important for translating peripheral metabolic signals and central neuronal inputs to a… Expand
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Review
2013
Review
2013
Orexins A and B (hypocretins 1 and 2) and their two receptors (OX1R and OX2R) were discovered in 1998 by two different groups… Expand
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Highly Cited
2013
Highly Cited
2013
Dual orexin receptor (OXR) antagonists (DORAs) such as almorexant, 1 (SB-649868), or suvorexant have shown promise for the… Expand
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2013
2013
Dual orexin receptor (OXR) antagonists (DORAs) such as almorexant, SB-649868, suvorexant (MK-4305), and filorexant (MK-6096… Expand
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Highly Cited
2012
Highly Cited
2012
STUDY OBJECTIVES To assess the acute effects of SB-649868 in male subjects with Primary Insomnia with regard to (1) objective and… Expand
Highly Cited
2012
Highly Cited
2012
The orexin system plays a major role in the integration of metabolic and circadian influences that drive wakefulness. This paper… Expand
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Highly Cited
2012
Highly Cited
2012
Orexins have a role in sleep regulation, and orexin receptor antagonists are under development for the treatment of insomnia. We… Expand
Highly Cited
2012
Highly Cited
2012
Orexins (OX) and their receptors (OXR) modulate feeding, arousal, stress, and drug abuse. Neural systems that motivate and… Expand
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2011
2011
N-[[(2S)-1-[[5-(4-fluorophenyl)-2-methyl-4-thiazolyl]carbonyl]-2-piperidinyl]methyl]-4-benzofurancarboxamide (SB-649868) is a… Expand
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