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S-Methyl-5'-Thioadenosine Phosphorylase

Known as: MTAPase, MeSAdo Phosphorylase, 5'-Methylthioadenosine Phosphorylase 
S-methyl-5'-thioadenosine phosphorylase (283 aa, ~31 kDa) is encoded by the human MTAP gene. This protein plays a role in amino acid, nucleotide and… 
National Institutes of Health

Related topics

Related topics

9 relations
5'-Methylthioadenosine phosphorylaseAmino Acid BiosynthesisCarbohydrate MetabolismCytoplasmic matrix

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2019
Highly Cited
2019
MTAP immunohistochemistry is an accurate and reproducible surrogate for CDKN2A fluorescence in situ hybridization in diagnosis of malignant pleural mesothelioma
Ancillary studies facilitate accurate diagnosis of morphologically challenging mesothelial proliferations. The current diagnostic… 
Highly Cited
2017
Highly Cited
2017
Immunohistochemical detection of MTAP and BAP1 protein loss for mesothelioma diagnosis: Comparison with 9p21 FISH and BAP1 immunohistochemistry.
Highly Cited
2017
Highly Cited
2017
Novel pleiotropic risk loci for melanoma and nevus density implicate multiple biological pathways
The total number of acquired melanocytic nevi on the skin is strongly correlated with melanoma risk. Here we report a meta… 
Highly Cited
2012
Highly Cited
2012
A Seven-Marker Signature and Clinical Outcome in Malignant Melanoma: A Large-Scale Tissue-Microarray Study with Two Independent Patient Cohorts
Background Current staging methods such as tumor thickness, ulceration and invasion of the sentinel node are known to be… 
Highly Cited
2010
Highly Cited
2010
CDKN2A and MTAP deletions in peritoneal mesotheliomas are correlated with loss of p16 protein expression and poor survival
Homozygous deletion of CDKN2A (p16) is one of the most common genetic alterations in pleural mesotheliomas, occurring in up to 74… 
Highly Cited
2003
Highly Cited
2003
Characterization of methylthioadenosin phosphorylase (MTAP) expression in malignant melanoma.
Highly Cited
1998
Highly Cited
1998
Homozygous deletions of methylthioadenosine phosphorylase (MTAP) are more frequent than p16INK4A (CDKN2) homozygous deletions in primary non-small cell lung cancers (NSCLC)
Homozygous deletions of the tumor suppressor gene p16INK4A and deficiency of methylthioadenosine phosphorylase (MTAP), both… 
Highly Cited
1996
Highly Cited
1996
Gene deletion chemoselectivity: codeletion of the genes for p16(INK4), methylthioadenosine phosphorylase, and the alpha- and beta-interferons in human pancreatic cell carcinoma lines and its…
Pancreatic carcinoma cells lines are known to have a high incidence of homozygous deletion of the candidate tumor suppressor gene… 
Highly Cited
1996
Highly Cited
1996
Frequent deletion in the methylthioadenosine phosphorylase gene in T-cell acute lymphoblastic leukemia: strategies for enzyme-targeted therapy.
Methylthioadenosine phosphorylase (MTAP), an enzyme essential for the salvage of adenine and methionine, is deficient in a… 
Highly Cited
1992
Highly Cited
1992
Mapping of the shortest region of overlap of deletions of the short arm of chromosome 9 associated with human neoplasia.
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