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Rifalazil
Known as:
3'-hydroxy-5'-(4-isobutyl-1-piperazinyl)benzoxazinorifamycin
, 3'-hydroxy-5'-(4-isobutylpiperazinyl)benzoxazinorifamycin
, benzoxazinorifamycin
National Institutes of Health
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KRM 1648
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Review
2010
Review
2010
Rifamycins--obstacles and opportunities.
P. Aristoff
,
G. Garcia
,
P. Kirchhoff
,
H. Showalter
Tuberculosis
2010
Corpus ID: 12791656
Review
2010
Review
2010
Resistance to rifampicin: at the crossroads between ecological, genomic and medical concerns.
A. Tupin
,
Maxime Gualtieri
,
Françoise Roquet-Banères
,
Zakia Morichaud
,
K. Brodolin
,
J. Leonetti
International Journal of Antimicrobial Agents
2010
Corpus ID: 19357646
2008
2008
Bisphosphonated Benzoxazinorifamycin Prodrugs for the Prevention and Treatment of Osteomyelitis
R. Reddy
,
Evelyne Dietrich
,
+12 authors
Adel Rafai Far
ChemMedChem
2008
Corpus ID: 11315014
Osteomyelitis represents a challenge to modern medicine. This inflammatory process is accompanied by bone necrosis, and results…
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Highly Cited
2007
Highly Cited
2007
In Vitro Activities of 15 Antimicrobial Agents against 110 Toxigenic Clostridium difficile Clinical Isolates Collected from 1983 to 2004
D. Hecht
,
Minerva A Galang
,
S. Sambol
,
J. Osmolski
,
Stuart Johnson
,
D. Gerding
Antimicrobial Agents and Chemotherapy
2007
Corpus ID: 33205502
ABSTRACT The incidence and severity of Clostridium difficile-associated disease (CDAD) is increasing, and standard treatment is…
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Highly Cited
2004
Highly Cited
2004
Rifalazil Treats and Prevents Relapse of Clostridium difficile-Associated Diarrhea in Hamsters
P. Anton
,
M. O'brien
,
+6 authors
C. Pothoulakis
Antimicrobial Agents and Chemotherapy
2004
Corpus ID: 22417098
ABSTRACT Although vancomycin and metronidazole effectively treat Clostridium difficile-associated diarrhea and colitis (CDAD…
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Highly Cited
2001
Highly Cited
2001
Safety and Bactericidal Activity of Rifalazil in Patients with Pulmonary Tuberculosis
R. Dietze
,
L. Teixeira
,
+6 authors
J. Ellner
Antimicrobial Agents and Chemotherapy
2001
Corpus ID: 32594728
ABSTRACT Rifalazil, also known as KRM-1648 or benzoxazinorifamycin, is a new semisynthetic rifamycin with a long half-life of…
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Highly Cited
1997
Highly Cited
1997
HIV protease inhibitors, saquinavir, indinavir and ritonavir: inhibition of CYP3A4-mediated metabolism of testosterone and benzoxazinorifamycin, KRM-1648, in human liver microsomes.
T. Inaba
,
N. Fischer
,
D. S. Riddick
,
D. Stewart
,
T. Hidaka
Toxicology Letters
1997
Corpus ID: 29770467
1995
1995
In vitro activity of the benzoxazinorifamycin KRM-1648 against drug-susceptible and multidrug-resistant tubercle bacilli
J. Luna-Herrera
,
M. V. Reddy
,
P. Gangadharam
Antimicrobial Agents and Chemotherapy
1995
Corpus ID: 42656573
We investigated the activity of benzoxazinorifamycin (KRM-1648) against several drug-susceptible and multidrug-resistant strains…
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Highly Cited
1995
Highly Cited
1995
In vitro and in vivo activities of the benzoxazinorifamycin KRM-1648 against Mycobacterium tuberculosis
T. Hirata
,
H. Saito
,
+4 authors
T. Hidaka
Antimicrobial Agents and Chemotherapy
1995
Corpus ID: 44938421
The in vitro and in vivo activities of a new benzoxazinorifamycin, KRM-1648 (KRM), against Mycobacterium tuberculosis were…
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Highly Cited
1992
Highly Cited
1992
Chemotherapeutic efficacy of a newly synthesized benzoxazinorifamycin, KRM-1648, against Mycobacterium avium complex infection induced in mice
H. Tomioka
,
H. Saito
,
+5 authors
T. Hidaka
Antimicrobial Agents and Chemotherapy
1992
Corpus ID: 41825740
Newly synthesized benzoxazinorifamycin, KRM-1648, was studied for its in vivo anti-Mycobacterium avium complex (MAC) activities…
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