Rifalazil

Known as: 3'-hydroxy-5'-(4-isobutyl-1-piperazinyl)benzoxazinorifamycin, 3'-hydroxy-5'-(4-isobutylpiperazinyl)benzoxazinorifamycin, benzoxazinorifamycin 
 
National Institutes of Health

Topic mentions per year

Topic mentions per year

1992-2017
0519922017

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2007
Highly Cited
2007
The incidence and severity of Clostridium difficile-associated disease (CDAD) is increasing, and standard treatment is not always… (More)
Is this relevant?
2007
2007
OBJECTIVES To determine the safety and effectiveness of single-dose rifalazil, a new rifamycin, for the treatment of… (More)
Is this relevant?
2005
2005
Although rifamycins have excellent activity against Chlamydophila pneumoniae and Chlamydia trachomatis in vitro, concerns about… (More)
  • table 1
Is this relevant?
2005
2005
Stable, homotypic mutants of Chlamydia trachomatis for which MICs of rifampin and rifalazil are elevated were isolated by serial… (More)
  • figure 1
  • table 1
  • table 2
  • table 3
  • table 4
Is this relevant?
2004
2004
Although vancomycin and metronidazole effectively treat Clostridium difficile-associated diarrhea and colitis (CDAD), their use… (More)
  • figure 1
  • figure 4
  • figure 2
  • figure 3
Is this relevant?
2001
2001
Rifalazil, also known as KRM-1648 or benzoxazinorifamycin, is a new semisynthetic rifamycin with a long half-life of… (More)
  • table 1
  • table 2
  • table 3
Is this relevant?
2000
2000
Previous experiments with rifalazil (RLZ) (also known as KRM-1648) in combination with isoniazid (INH) demonstrated its potential… (More)
Is this relevant?
1995
1995
The mechanism of antimicrobial activity of KRM-1648 (KRM), a new rifamycin derivative with potent antimycobacterial activity, was… (More)
  • figure 1
  • table 1
  • figure 4
  • figure 2
  • figure 3
Is this relevant?
1995
1995
We investigated the activity of benzoxazinorifamycin (KRM-1648) against several drug-susceptible and multidrug-resistant strains… (More)
Is this relevant?
1994
1994
The activity of KRM-1648 was evaluated in a murine model of tuberculosis. Approximately 10(7) viable Mycobacterium tuberculosis… (More)
Is this relevant?