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Rifalazil

Known as: 3'-hydroxy-5'-(4-isobutyl-1-piperazinyl)benzoxazinorifamycin, 3'-hydroxy-5'-(4-isobutylpiperazinyl)benzoxazinorifamycin, benzoxazinorifamycin 
National Institutes of Health

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KRM 1648

Papers overview

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Review
2003
Review
2003
Development potential of rifalazil
Rifalazil represents a new generation of ansamycins that contain a unique four-ring structure. Originally rifalazil was developed… 
1999
1999
Isolation and identification of major metabolites of rifalazil in mouse and human.
1. Three metabolites of rifalazil have been isolated from dog urine and identified as 25-deacetyl-rifalazil, 30-hydroxy-rifalazil… 
1998
1998
Antimicrobial activities of benzoxazinorifamycin KRM-1648, clarithromycin and levofloxacin against intracellular Mycobacterium avium complex phagocytosed by murine peritoneal macrophages.
The in-vitro activities of KRM-1648, a new benzoxazinorifamycin, clarithromycin and levofloxacin against clinical isolates of… 
1997
1997
HIV protease inhibitors, saquinavir, indinavir and ritonavir: inhibition of CYP3A4-mediated metabolism of testosterone and benzoxazinorifamycin, KRM-1648, in human liver microsomes.
1997
1997
Effects of benzoxazinorifamycin KRM-1648 on cytokine production at sites of Mycobacterium avium complex infection induced in mice
Although various antimicrobial agents exhibit appreciable microbicidal activity in the early phase (weeks 2 t0 4) of… 
1996
1996
In vitro metabolism of a rifamycin derivative by animal and human liver microsomes, whole blood and expressed human CYP3A isoform.
1. In vitro metabolism of a rifamycin derivative, benzoxazinorifamycin KRM-1648, was studied using mouse, rat, guinea pig, dog… 
1995
1995
Therapeutic effect of KRM-1648 with various antimicrobials against Mycobacterium avium complex infection in mice.
1994
1994
Activities of the benzoxazinorifamycin KRM 1648 and ethambutol against Mycobacterium avium complex in vitro and in macrophages
KRM 1648 is a 4-aminobenzoxazine derivative of rifamycin S with potent in vitro activity against the Mycobacterium avium complex… 
1993
1993
Therapeutic efficacy of the benzoxazinorifamycin KRM-1648 against experimental Mycobacterium avium infection induced in rabbits
The therapeutic efficacy of the benzoxazinorifamycin KRM-1648 was studied in an experimental rabbit infection system with avian… 
Highly Cited
1992
Highly Cited
1992
Chemotherapeutic efficacy of a newly synthesized benzoxazinorifamycin, KRM-1648, against Mycobacterium avium complex infection induced in mice
Newly synthesized benzoxazinorifamycin, KRM-1648, was studied for its in vivo anti-Mycobacterium avium complex (MAC) activities… 
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