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Rifalazil

Known as: 3'-hydroxy-5'-(4-isobutyl-1-piperazinyl)benzoxazinorifamycin, 3'-hydroxy-5'-(4-isobutylpiperazinyl)benzoxazinorifamycin, benzoxazinorifamycin 
 
National Institutes of Health

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KRM 1648

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2013
2013
X-ray crystal structures of the Escherichia coli RNA polymerase in complex with benzoxazinorifamycins.
Rifampin, a semisynthetic rifamycin, is the cornerstone of current tuberculosis treatment. Among many semisynthetic rifamycins… Expand
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2008
2008
Bisphosphonated Benzoxazinorifamycin Prodrugs for the Prevention and Treatment of Osteomyelitis
Osteomyelitis represents a challenge to modern medicine. This inflammatory process is accompanied by bone necrosis, and results… Expand
Highly Cited
2007
Highly Cited
2007
In Vitro Activities of 15 Antimicrobial Agents against 110 Toxigenic Clostridium difficile Clinical Isolates Collected from 1983 to 2004
ABSTRACT The incidence and severity of Clostridium difficile-associated disease (CDAD) is increasing, and standard treatment is… Expand
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Highly Cited
2004
Highly Cited
2004
Rifalazil Treats and Prevents Relapse of Clostridium difficile-Associated Diarrhea in Hamsters
ABSTRACT Although vancomycin and metronidazole effectively treat Clostridium difficile-associated diarrhea and colitis (CDAD… Expand
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Highly Cited
2001
Highly Cited
2001
Safety and Bactericidal Activity of Rifalazil in Patients with Pulmonary Tuberculosis
ABSTRACT Rifalazil, also known as KRM-1648 or benzoxazinorifamycin, is a new semisynthetic rifamycin with a long half-life of… Expand
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Highly Cited
1997
Highly Cited
1997
HIV protease inhibitors, saquinavir, indinavir and ritonavir: inhibition of CYP3A4-mediated metabolism of testosterone and benzoxazinorifamycin, KRM-1648, in human liver microsomes.
The protease inhibitors, ritonavir, indinavir and saquinavir, the most potent anti-HIV drugs developed to date, interact with… Expand
1995
1995
In vitro activity of the benzoxazinorifamycin KRM-1648 against drug-susceptible and multidrug-resistant tubercle bacilli.
We investigated the activity of benzoxazinorifamycin (KRM-1648) against several drug-susceptible and multidrug-resistant strains… Expand
Highly Cited
1995
Highly Cited
1995
In vitro and in vivo activities of the benzoxazinorifamycin KRM-1648 against Mycobacterium tuberculosis.
The in vitro and in vivo activities of a new benzoxazinorifamycin, KRM-1648 (KRM), against Mycobacterium tuberculosis were… Expand
1993
1993
Synthesis and biological activity of 3'-hydroxy-5'-aminobenzoxazinorifamycin derivatives.
As a part of our studies on the syntheses of benzoxazinorifamycin derivatives, 3'-hydroxy-5'-aminobenzoxazinorifamycin… Expand
Highly Cited
1992
Highly Cited
1992
Chemotherapeutic efficacy of a newly synthesized benzoxazinorifamycin, KRM-1648, against Mycobacterium avium complex infection induced in mice.
Newly synthesized benzoxazinorifamycin, KRM-1648, was studied for its in vivo anti-Mycobacterium avium complex (MAC) activities… Expand
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