FAQ

Rifalazil

Known as: 3'-hydroxy-5'-(4-isobutyl-1-piperazinyl)benzoxazinorifamycin, 3'-hydroxy-5'-(4-isobutylpiperazinyl)benzoxazinorifamycin, benzoxazinorifamycin 
 
National Institutes of Health

Topic mentions per year

Topic mentions per year

1992-2017
0519922017

Related topics

Related topics

1 relation

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KRM 1648

Related mentions per year

Related mentions per year

1991-2017
1990200020102020
Rifalazil
KRM 1648

Papers overview

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Highly Cited
2007
Highly Cited
2007
In vitro activities of 15 antimicrobial agents against 110 toxigenic clostridium difficile clinical isolates collected from 1983 to 2004.
The incidence and severity of Clostridium difficile-associated disease (CDAD) is increasing, and standard treatment is not always… (More)
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2007
2007
A randomized, double-blind study comparing single-dose rifalazil with single-dose azithromycin for the empirical treatment of nongonococcal urethritis in men.
OBJECTIVES To determine the safety and effectiveness of single-dose rifalazil, a new rifamycin, for the treatment of… (More)
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2005
2005
Emergence of resistance to rifampin and rifalazil in Chlamydophila pneumoniae and Chlamydia trachomatis.
Although rifamycins have excellent activity against Chlamydophila pneumoniae and Chlamydia trachomatis in vitro, concerns about… (More)
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2005
2005
Rifampin-resistant RNA polymerase mutants of Chlamydia trachomatis remain susceptible to the ansamycin rifalazil.
Stable, homotypic mutants of Chlamydia trachomatis for which MICs of rifampin and rifalazil are elevated were isolated by serial… (More)
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2004
2004
Rifalazil treats and prevents relapse of clostridium difficile-associated diarrhea in hamsters.
Although vancomycin and metronidazole effectively treat Clostridium difficile-associated diarrhea and colitis (CDAD), their use… (More)
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2001
2001
Safety and bactericidal activity of rifalazil in patients with pulmonary tuberculosis.
Rifalazil, also known as KRM-1648 or benzoxazinorifamycin, is a new semisynthetic rifamycin with a long half-life of… (More)
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2000
2000
Evaluation of rifalazil in long-term treatment regimens for tuberculosis in mice.
Previous experiments with rifalazil (RLZ) (also known as KRM-1648) in combination with isoniazid (INH) demonstrated its potential… (More)
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1995
1995
Mechanism of action of antimycobacterial activity of the new benzoxazinorifamycin KRM-1648.
The mechanism of antimicrobial activity of KRM-1648 (KRM), a new rifamycin derivative with potent antimycobacterial activity, was… (More)
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1995
1995
In vitro activity of the benzoxazinorifamycin KRM-1648 against drug-susceptible and multidrug-resistant tubercle bacilli.
We investigated the activity of benzoxazinorifamycin (KRM-1648) against several drug-susceptible and multidrug-resistant strains… (More)
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1994
1994
Activity of KRM-1648, a new benzoxazinorifamycin, against Mycobacterium tuberculosis in a murine model.
The activity of KRM-1648 was evaluated in a murine model of tuberculosis. Approximately 10(7) viable Mycobacterium tuberculosis… (More)
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