FAQ

Relaxin

Known as: Relaxin [Chemical/Ingredient] 
A water-soluble polypeptide (molecular weight approximately 8,000) extractable from the corpus luteum of pregnancy. It produces relaxation of the… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1944-2017
05010019442016

Related topics

Related topics

14 relations
In BloodProcess of secretionadministration & dosageagonists
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Broader (2)

peptide hormonereproductive hormone

Narrower (2)

preprorelaxinprorelaxin

Related mentions per year

Related mentions per year

1936-2018
19401960198020002020
Relaxin
physiological aspects
agonists
peptide hormone
chemical synthesis
standards characteristics

Papers overview

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Highly Cited
2009
Highly Cited
2009
Relaxin for the treatment of patients with acute heart failure (Pre-RELAX-AHF): a multicentre, randomised, placebo-controlled, parallel-group, dose-finding phase IIb study.
BACKGROUND Most patients admitted for acute heart failure have normal or increase blood pressure. Relaxin is a natural human… (More)
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2004
2004
Evolution of the relaxin-like peptide family
The relaxin-like peptide family belongs in the insulin superfamily and consists of 7 peptides of high structural but low sequence… (More)
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Highly Cited
2004
Highly Cited
2004
Relaxin modulates cardiac fibroblast proliferation, differentiation, and collagen production and reverses cardiac fibrosis in vivo.
Cardiac fibrosis is a key component of heart disease and involves the proliferation and differentiation of matrix-producing… (More)
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Highly Cited
2003
Highly Cited
2003
Identification of relaxin-3/INSL7 as an endogenous ligand for the orphan G-protein-coupled receptor GPCR135.
GPCR135, publicly known as somatostatin- and angiotensin-like peptide receptor, is expressed in the central nervous system and… (More)
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Highly Cited
2003
Highly Cited
2003
Identification of relaxin-3/INSL7 as a ligand for GPCR142.
We have recently identified the insulin-like peptide relaxin-3 (aka INSL7) as the endogenous ligand for an orphan G-protein… (More)
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Highly Cited
2002
Highly Cited
2002
Activation of orphan receptors by the hormone relaxin.
Relaxin is a hormone important for the growth and remodeling of reproductive and other tissues during pregnancy. Although binding… (More)
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Highly Cited
2002
Highly Cited
2002
Human relaxin gene 3 (H3) and the equivalent mouse relaxin (M3) gene. Novel members of the relaxin peptide family.
We have identified a novel human relaxin gene, designated H3 relaxin, and an equivalent relaxin gene in the mouse from the Celera… (More)
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Highly Cited
1999
Highly Cited
1999
Relaxin is a potent renal vasodilator in conscious rats.
The kidneys and other nonreproductive organs vasodilate during early gestation; however, the "pregnancy hormones" responsible for… (More)
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Highly Cited
1996
Highly Cited
1996
Relaxin induces an extracellular matrix-degrading phenotype in human lung fibroblasts in vitro and inhibits lung fibrosis in a murine model in vivo.
Pulmonary fibrosis is the common end stage of a number of pneumopathies. In this study, we examined the ability of the human… (More)
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Highly Cited
1995
Highly Cited
1995
Radiological assessment of relaxin-induced pubic symphyseal changes in guinea pigs: A model for screening disease modifying agents for osteoarthritis
Cartilage degeneration in the pubic symphysis of pregnant guinea pigs shares many features with interleukin-1 (IL-1) mediated… (More)
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