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Razupenem

Known as: (4R,5S,6S)-6-((1r)-1-Hydroxyethyl)-4-Methyl-3-((4-((5S)-5-Methyl-2,5-Dihydro-1H-Pyrrol-3-yl)Thiazol-2-yl)Sulfanyl)-7-Oxo-1-Azabicyclo(3.2.0)Hept-2-Ene-2-Carboxylic Acid 
A broad-spectrum carbapenem with activity against gram-positive bacteria, including methicillin-resistant S. aureus.
National Institutes of Health

Papers overview

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Review
2017
Review
2017
Carbapenems are among the most commonly used and the most efficient antibiotics since they are relatively resistant to hydrolysis… Expand
2014
2014
The emergence of Gram‐negative “superbugs” exhibiting resistance to known antibacterials poses a major public health concern. Low… Expand
2013
2013
To obtain a status of a medicinal product, a compound possessing potential antimicrobial activity and displaying no cytotoxicity… Expand
2013
2013
New Delhi metallo-beta-lactamase (NDM-1) is a beta-lactamase (class B carbapenemase) containing Zn2+ and other divalent cations… Expand
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2011
2011
ABSTRACT Simulations of administration of razupenem at 1 g every 12 h by 1-h intravenous (i.v.) infusion were performed in an in… Expand
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2011
2011
ABSTRACT We evaluated the in vitro antianaerobic activity of razupenem (SMP-601, PTZ601), a new parenterally administered… Expand
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Review
2009
Review
2009
  • D. Livermore
  • The Journal of antimicrobial chemotherapy
  • 2009
  • Corpus ID: 40761788
Antibiotic resistance is a major public health concern, with fears expressed that we shortly will run out of antibiotics. In… Expand
2009
2009
BACKGROUND Razupenem (previously known as PTZ601, PZ-601, SMP-601 or SM-216601) is a novel carbapenem, active against… Expand
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2009
2009
ABSTRACT Multistep and single-step resistance selection studies were performed with razupenem, linezolid, and vancomycin against… Expand
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2009
2009
  • M. Page, J. Heim
  • IDrugs : the investigational drugs journal
  • 2009
  • Corpus ID: 20133919
Beta-lactams are among the most successful classes of antibiotics, both medically and commercially. However, more than 60 years… Expand