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Razupenem

Known as: (4R,5S,6S)-6-((1r)-1-Hydroxyethyl)-4-Methyl-3-((4-((5S)-5-Methyl-2,5-Dihydro-1H-Pyrrol-3-yl)Thiazol-2-yl)Sulfanyl)-7-Oxo-1-Azabicyclo(3.2.0)Hept-2-Ene-2-Carboxylic Acid 
A broad-spectrum carbapenem with activity against gram-positive bacteria, including methicillin-resistant S. aureus.
National Institutes of Health

Papers overview

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Review
2017
Review
2017
2014
2014
The emergence of Gram‐negative “superbugs” exhibiting resistance to known antibacterials poses a major public health concern. Low… 
2013
2013
To obtain a status of a medicinal product, a compound possessing potential antimicrobial activity and displaying no cytotoxicity… 
2013
2013
New Delhi metallo-beta-lactamase (NDM-1) is a beta-lactamase (class B carbapenemase) containing Zn2+ and other divalent cations… 
2011
2011
ABSTRACT Simulations of administration of razupenem at 1 g every 12 h by 1-h intravenous (i.v.) infusion were performed in an in… 
2011
2011
ABSTRACT We evaluated the in vitro antianaerobic activity of razupenem (SMP-601, PTZ601), a new parenterally administered… 
Review
2009
Review
2009
  • D. Livermore
  • The Journal of antimicrobial chemotherapy
  • 2009
  • Corpus ID: 40761788
Antibiotic resistance is a major public health concern, with fears expressed that we shortly will run out of antibiotics. In… 
2009
2009
BACKGROUND Razupenem (previously known as PTZ601, PZ-601, SMP-601 or SM-216601) is a novel carbapenem, active against… 
2009
2009
ABSTRACT Multistep and single-step resistance selection studies were performed with razupenem, linezolid, and vancomycin against… 
2009
2009
  • M. Page, J. Heim
  • IDrugs : the investigational drugs journal
  • 2009
  • Corpus ID: 20133919
Beta-lactams are among the most successful classes of antibiotics, both medically and commercially. However, more than 60 years…