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Rad51B-Rad51C-Rad51D-XRCC2 complex

Known as: BCDX2 complex, BCDX2 complex location, Rad51B-Rad51C-Rad51D-XRCC2 complex location 
A DNA recombinase mediator complex that contains the Rad51 paralogs RAD51B, RAD51C, RAD51D, and XRCC2, or orthologs thereof. [GOC:mah, PMID:16093548… Expand
National Institutes of Health

Papers overview

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Highly Cited
2013
Highly Cited
2013
Rad51 paralog complexes BCDX2 and CX3 act at different stages in the BRCA1-BRCA2-dependent homologous recombination pathway.
The Rad51 paralogs are required for homologous recombination (HR) and the maintenance of genomic stability. The molecular… Expand
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2010
2010
Ring-shaped Rad51 Paralog Protein Complexes Bind Holliday Junctions and Replication Forks as Visualized by Electron Microscopy*
In mammals, there are five Rad51 paralogs that form two distinct complexes in vivo. One complex is composed of Rad51B-Rad51C… Expand
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Highly Cited
2007
Highly Cited
2007
Role of RAD51C and XRCC3 in Genetic Recombination and DNA Repair*
In germ line cells, recombination is required for gene reassortment and proper chromosome segregation at meiosis, whereas in… Expand
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2007
2007
The RAD51D E233G variant and breast cancer risk: population-based and clinic-based family studies of Australian women
RAD51D is a homolog of the RAD51 protein, which is known to be an important component of the DNA repair pathway. A rare missense… Expand
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Highly Cited
2004
Highly Cited
2004
Human Rad51C Deficiency Destabilizes XRCC3, Impairs Recombination, and Radiosensitizes S/G2-phase Cells*
The highly conserved Rad51 protein plays an essential role in repairing DNA damage through homologous recombination. In… Expand
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Highly Cited
2004
Highly Cited
2004
Domain mapping of the Rad51 paralog protein complexes.
The five human Rad51 paralogs are suggested to play an important role in the maintenance of genome stability through their… Expand
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Highly Cited
2002
Highly Cited
2002
A potential role for the XRCC2 R188H polymorphic site in DNA-damage repair and breast cancer.
An acquired genetic instability, resulting from the loss of some types of DNA repair, is an early event in the development of a… Expand
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Highly Cited
2002
Highly Cited
2002
Involvement of Rad51C in two distinct protein complexes of Rad51 paralogs in human cells.
Genetic studies in rodent and chicken mutant cell lines have suggested that Rad51 paralogs (XRCC2, XRCC3, Rad51B/Rad51L1, Rad51C… Expand
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Highly Cited
2002
Highly Cited
2002
Interactions involving the Rad51 paralogs Rad51C and XRCC3 in human cells.
Homologous recombinational repair of DNA double-strand breaks and crosslinks in human cells is likely to require Rad51 and the… Expand
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2002
2002
Interactions involving the Rad 51 paralogs Rad 51 C and XRCC 3 in human cells
Homologous recombinational repair of DNA doublestrand breaks and crosslinks in human cells is likely to require Rad51 and the… Expand
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