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RS 86

Known as: RS-86 
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
1993
1993
Synthesis and pharmacological evaluation of a new class of 2-oxo-8-azaspiro (4,5)decan-1-ones as analogues of the muscarinic agonist RS-86.
A new series of 8-substituted-2-oxo-8-azaspiro (4,5)decan-1-ones has been synthesized and compounds tested for their cholinergic… 
1992
1992
Comparative pharmacological profile of muscarinic agonists in the isolated ileum, the pithed rat, and the mouse charcoal meal transit test.
Highly Cited
1989
Highly Cited
1989
The cholinergic rapid eye movement sleep induction test with RS-86. State or trait marker of depression?
Rapid eye movement (REM) sleep disinhibition at the beginning of the night is one of the most frequently described biologic… 
1989
1989
EEG Mapping During Cholinergic Drug Challenge with RS-86
The cholinergic-adrenergic balance hypothesis of affective disorders postulates cholinergic overactivity in depression (Janowsky… 
Highly Cited
1988
Highly Cited
1988
No response to high‐dose muscarinic agonist therapy in Alzheimer's disease
Cholinergic deficiency is the most consistent transmitter system abnormality in Alzheimer's disease. To test the acute… 
1988
1988
Role of dentate gyrus cells in retention of a radial arm maze task and sensitivity of rats to cholinergic drugs.
Male adult Fischer-344 rats that received bilateral injections of colchicine into two rostrocaudal sites showed relatively long… 
1988
1988
2-Methyl-1,3-dioxaazaspiro[4.5]decanes as novel muscarinic cholinergic agonists.
Many nonquaternary ammonium muscarinic agonists have been developed over the last few years, but most of the existing compounds… 
1986
1986
Animal Models of Alzheimer's Disease: Behavior, Pharmacology, Transplants
Abstract: Physostigmine, oxotremorine, RS-86, and a combination of piracetam and lecithin, have all been studied in patients with… 
1983
1983
Cholinergic potentiation of neuroleptic effects in the nucleus accumbens.
The CNS cholinergic agonist spiro-(1-methyl-4-piperidyl)-N-ethyl-succinimide (RS-86) potentiated the ability of typical… 
1977
1977
Δ9-Tetrahydrocannabinol and the extrapyramidal system
The behavioural effects of stereotypy and catalepsy by Δ9-Tetrahydrocannabinol (Δ9-THC) in the rat were estimated and the… 
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