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RRM2 gene

Known as: RIBONUCLEOTIDE REDUCTASE, R2 SUBUNIT, RRM2, R2 
This gene is involved in the promotion of cell cycle-specific gene expression.
National Institutes of Health

Related topics

Related topics

6 relations
Cell ProliferationDNA ReplicationDrug resistanceOxidation-Reduction

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
Atomic-level evidence for packing and positional amyloid polymorphism by segment from TDP-43 RRM2
Proteins in the fibrous amyloid state are a major hallmark of neurodegenerative disease. Understanding the multiple conformations… 
2017
2017
APLP2, RRM2, and PRC1: New Putative Markers for the Differential Diagnosis of Thyroid Follicular Lesions.
BACKGROUND Current methods based on fine-needle aspiration biopsy (FNAB) are not sufficient to distinguish among follicular… 
2017
2017
Vasohibin 2 reduces chemosensitivity to gemcitabine in pancreatic cancer cells via Jun proto-oncogene dependent transactivation of ribonucleotide reductase regulatory subunit M2
Vasohibin 2 (VASH2) has previously been identified as an agiogenenic factor and a cancer related protein. Here we investigated… 
2014
2014
MicroRNA Modulation Induced by AICA Ribonucleotide in J1 Mouse ES Cells
ES cells can propagate indefinitely, maintain self-renewal, and differentiate into almost any cell type of the body. These… 
2012
2012
Abstract A30: Differential processing of let 7a precursors influences gemcitabine chemosensitivity in pancreatic cancer: Role of ribonucleotide reductase subunit M2.
Ribonucleotide reductase subunit M2 (RRM2) involved in deoxyribonucleotide synthesis acts as a key determinant of chemoresistance… 
2012
2012
Three RNA recognition motifs participate in RNA recognition and structural organization by the pro-apoptotic factor TIA-1.
2011
2011
siRNA knockdown of ribonucleotide reductase inhibits melanoma cell line proliferation alone or synergistically with temozolomide.
Systemically delivered small interfering RNA (siRNA) therapies for cancer have begun clinical development. The effects of siRNA… 
2010
2010
Abstract 3677: Nanoparticle mediated delivery of siRNA targeting RRM2 inhibits tumor growth of head and neck and lung cancers
Proceedings: AACR 101st Annual Meeting 2010‐‐ Apr 17‐21, 2010; Washington, DC Inhibition of specific genes by small interfering… 
Highly Cited
2006
Highly Cited
2006
Structural characterization of Set1 RNA recognition motifs and their role in histone H3 lysine 4 methylation.
1994
1994
Characterization of cDNAs encoding the murine A+U-rich RNA-binding protein AUF1.
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