RPA bicyclam
National Institutes of Health
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Expression of the chemokine receptor chemokine C-X-C motif receptor 4 (CXCR4) plays an important role in cancer metastasis, in…
Positron emission tomography (PET) imaging is a non-invasive modality that permits the characterisation of biological processes…
For instance,one of the metallocyclam units in the metalloxylyl-bicy-clam is folded with Cis-V configuration, where the…
Background: The development of distant metastasis is associated with poor outcome in patients with colorectal cancer (CRC). The…
The bicyclam AMD3100 is known as a small synthetic inhibitor of the CXCL12-binding chemokine receptor CXCR4. Here, we show that…
The macrocyclic antiviral drug xylyl-bicyclam blocks entry of HIV into cells by targeting the CXCR4 coreceptor, a seven-helix…
As platforms for the design of metal-based therapeutic and diagnostic agents, macrocycles are rigid enough to provide strong…
The bicyclam AMD3100 is a highly potent and selective CXCR4 antagonist with strong antiviral activity against human…
ABSTRACT The emergence of X4 human immunodeficiency virus type 1 (HIV-1) strains in HIV-1-infected individuals has been…