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RPA bicyclam

 
National Institutes of Health

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JM 3100

Papers overview

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2020
2020
64Cu PET Imaging of the CXCR4 Chemokine Receptor Using a Cross-Bridged Cyclam Bis-Tetraazamacrocyclic Antagonist
Expression of the chemokine receptor chemokine C-X-C motif receptor 4 (CXCR4) plays an important role in cancer metastasis, in… Expand
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2018
2018
Characterisation of targeted imaging and theranostic agents for cancer and fibrosis
Positron emission tomography (PET) imaging is a non-invasive modality that permits the characterisation of biological processes… Expand
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2014
2014
Oxometallate(VI) (M = Mo, W) Bridged Cadmium(II) Cyclam Dimers Bearing Cis-V Configurations
For instance,one of the metallocyclam units in the metalloxylyl-bicy-clam is folded with Cis-V configuration, where the… Expand
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2011
2011
A Lentiviral CXCR4 Overexpression and Knockdown Model in Colorectal Cancer Cell Lines Reveals Plerixafor-Dependent Suppression of SDF-1α-Induced Migration and Invasion
Background: The development of distant metastasis is associated with poor outcome in patients with colorectal cancer (CRC). The… Expand
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Highly Cited
2009
Highly Cited
2009
AMD3100 Is a CXCR7 Ligand with Allosteric Agonist Properties
The bicyclam AMD3100 is known as a small synthetic inhibitor of the CXCL12-binding chemokine receptor CXCR4. Here, we show that… Expand
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Highly Cited
2005
Highly Cited
2005
AMD3465, a monomacrocyclic CXCR4 antagonist and potent HIV entry inhibitor.
The chemokine receptors CCR5 and CXCR4 function as coreceptors for human immunodeficiency virus (HIV) and are attractive targets… Expand
Highly Cited
2005
Highly Cited
2005
Protein recognition of macrocycles: binding of anti-HIV metallocyclams to lysozyme.
The macrocyclic antiviral drug xylyl-bicyclam blocks entry of HIV into cells by targeting the CXCR4 coreceptor, a seven-helix… Expand
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Highly Cited
2002
Highly Cited
2002
Structure and dynamics of metallomacrocycles: recognition of zinc xylyl-bicyclam by an HIV coreceptor.
As platforms for the design of metal-based therapeutic and diagnostic agents, macrocycles are rigid enough to provide strong… Expand
Highly Cited
2001
Highly Cited
2001
Mutation of Asp(171) and Asp(262) of the chemokine receptor CXCR4 impairs its coreceptor function for human immunodeficiency virus-1 entry and abrogates the antagonistic activity of AMD3100.
The bicyclam AMD3100 is a highly potent and selective CXCR4 antagonist with strong antiviral activity against human… Expand
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Highly Cited
1999
Highly Cited
1999
Shift of Clinical Human Immunodeficiency Virus Type 1 Isolates from X4 to R5 and Prevention of Emergence of the Syncytium-Inducing Phenotype by Blockade of CXCR4
ABSTRACT The emergence of X4 human immunodeficiency virus type 1 (HIV-1) strains in HIV-1-infected individuals has been… Expand
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