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RO4987655

Known as: MEK Inhibitor RO4987655 
An orally active small molecule, targeting mitogen-activated protein kinase kinase 1 (MAP2K1 or MEK1), with potential antineoplastic activity. MEK… 
National Institutes of Health

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CH 4987655

Papers overview

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2017
2017
Marcadores moleculares predictivos de respuesta en pacientes con tumores sólidos avanzados tratados con inhibidores de mek y raf dentro de estudios fase i
La via de RAS/RAF/MEK/ERK proteinas quinasas activadas por mitogenos (MAPK) esta implicada en la proliferacion, diferenciacion… 
2014
2014
Phase I and pharmacokinetics/pharmacodynamics (PK/PD) study of MEK inhibitor, RO4987655, in Japanese patients with advanced solid tumors.
116 Background: RO4987655 is an oral and selective inhibitor of MEK, a key enzyme of the MAPK signaling pathway. This was a phase… 
2012
2012
developmental therapeutics 438 O PHASE II ACTIVITY OF THE HSP 90 INHIBITOR AUY 922 IN PATIENTS WITH ALK-REARRANGED ( ALK + ) OR EGFR-MUTATED ADVANCED NON-SMALL CELL LUNG CANCER ( NSCLC )
E. Felip1, E. Carcereny2, F. Barlesi3, L. Gandhi4, L.V. Sequist5, S-W. Kim6, H.J. M. Groen7, B. Besse8, D-W. Kim9, E. Smit10, M… 
2009
2009
Cancer Therapy : Clinical The Safety , Tolerability , Pharmacokinetics , and Pharmacodynamics of Single Oral Doses of CH 4987655 in Healthy Volunteers : Target Suppression Using a Biomarker
Purpose:CH4987655 (RO4987655) is an orally active and highly selective small-molecule MEK inhibitor. It potently inhibits mitogen… 
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