Skip to search formSkip to main content
You are currently offline. Some features of the site may not work correctly.

RO4987655

Known as: MEK Inhibitor RO4987655 
An orally active small molecule, targeting mitogen-activated protein kinase kinase 1 (MAP2K1 or MEK1), with potential antineoplastic activity. MEK… Expand
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
MAPK pathway activation is frequently observed in human malignancies, including melanoma, and is associated with sensitivity to… Expand
  • table 1
  • table 2
  • table 3
2015
2015
RO4987655 is an oral and selective inhibitor of MEK, a key enzyme of the mitogen-activated protein kinase (MAPK) signaling… Expand
  • table 2
  • figure 1
  • table 3
  • figure 2
  • table 4
Highly Cited
2014
Highly Cited
2014
Purpose: This phase I expansion study assessed safety, pharmacodynamic effects, and antitumor activity of RO4987655, a pure MEK… Expand
  • table 1
  • table 2
  • figure 1
  • figure 2
  • table 3
Review
2014
Review
2014
Mitogen-activated protein kinases (MAPKs) are a family of ubiquitous eukaryotic signal transduction enzymes which link… Expand
  • figure 1
  • figure 2
  • table 1
2014
2014
BackgroundInhibition of mitogen-activated protein kinase (MEK, also known as MAPK2, MAPKK), a key molecule of the Ras/MAPK… Expand
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Review
2013
Review
2013
Four distinct MAP kinase signaling pathways involving 7 MEK enzymes have been identified. MEK1 and MEK2 are the prototype members… Expand
  • figure 1
  • figure 2
  • table 1
  • figure 3
Highly Cited
2012
Highly Cited
2012
Purpose: This phase I study of the mitogen-activated protein/extracellular signal–regulated kinase inhibitor RO4987655 (CH4987655… Expand
  • table 1
  • figure 1
  • figure 2
  • table 3
  • figure 3
2012
2012
Two mitogen-activated protein kinase kinase (MAPK2, also known as MEK) inhibitors were assessed with 18F-FDG PET in separate… Expand
  • table 1
  • table 2
  • figure 1
  • figure 1
  • figure 2
2011
2011
3017 Background: Mutations of Ras/Raf lead to a sustained and constitutive activation of ERK pathway. MEK1/2 is the only enzyme… Expand
2009
2009
Purpose: CH4987655 (RO4987655) is an orally active and highly selective small-molecule MEK inhibitor. It potently inhibits… Expand
  • table 1
  • table 2
  • figure 2
  • figure 1
  • figure 3