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RO4917523

National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2019
Review
2019
A new generation of antidepressants: an update on the pharmaceutical pipeline for novel and rapid-acting therapeutics in mood disorders based on glutamate/GABA neurotransmitter systems.
2018
2018
Bidirectional variation in glutamate efflux in the medial prefrontal cortex induced by selective positive and negative allosteric mGluR5 modulators
Dysregulation of prefrontal cortical glutamatergic signalling via NMDA receptor hypofunction has been implicated in cognitive… 
Highly Cited
2015
Highly Cited
2015
Pharmacology of Basimglurant (RO4917523, RG7090), a Unique Metabotropic Glutamate Receptor 5 Negative Allosteric Modulator in Clinical Development for Depression
Major depressive disorder (MDD) is a serious public health burden and a leading cause of disability. Its pharmacotherapy is… 
Review
2015
Review
2015
Ketamine and other potential glutamate antidepressants
Highly Cited
2015
Highly Cited
2015
Metabotropic glutamate receptor 5 negative allosteric modulators: discovery of 2-chloro-4-[1-(4-fluorophenyl)-2,5-dimethyl-1H-imidazol-4-ylethynyl]pyridine (basimglurant, RO4917523), a promising…
Negative allosteric modulators (NAMs) of metabotropic glutamate receptor 5 (mGlu5) have potential for the treatment of… 
2015
2015
Dissociable effects of mGluR5 allosteric modulation on distinct forms of impulsivity in rats: interaction with NMDA receptor antagonism
Impaired N-methyl-d-aspartate (NMDA) receptor signalling underlies several psychiatric disorders that express high levels of… 
Review
2013
Review
2013
Glutamate modulators as potential therapeutic drugs in schizophrenia and affective disorders
Severe psychiatric disorders such as schizophrenia are related to cognitive and negative symptoms, which often are resistant to… 
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