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RO 4929097

Known as: Gamma-Secretase Inhibitor RO4929097, RO-4929097, RO4929097 
An orally bioavailable, small-molecule gamma secretase (GS) inhibitorwith potential antitumor activity. Gamma secretase inhibitor RO4929097 binds to… 
National Institutes of Health

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NCIt Antineoplastic Agent Terminology

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2016
2016
Anti-myeloma effect of pharmacological inhibition of Notch/gamma-secretase with RO4929097 is mediated by modulation of tumor microenvironment
ABSTRACT Multiple myeloma (MM), a blood cancer characterized by the uncontrolled proliferation of plasma cells, remains incurable… 
2014
2014
Use of small molecule inhibitors of the Wnt and Notch signaling pathways during Xenopus development.
2013
2013
PTEN regulates sensitivity of melanoma cells to RO4929097, the γ-secretase inhibitor.
De-regulated expression of components of the Notch signaling pathway is observed in malignant melanoma. This pathway is activated… 
2013
2013
A phase I/II trial combining erlotinib with gamma secretase inhibitor RO4929097 in advanced non-small cell lung cancer (NSCLC).
8104 Background: All NSCLC patients treated with erlotinib (E) eventually develop resistance. Both the epithelial-mesenchymal… 
2012
2012
Moving forward one Notch at a time.
In the articles that accompany this editorial, Tolcher et al and Krop et al report the results of two phase I studies that… 
2012
2012
Abstract P2-14-04: A Phase Ib Dose Escalation Trial of RO4929097 (a γ-secretase inhibitor) in Combination with Exemestane in Patients with ER + Metastatic Breast Cancer.
Background: RO4929097 is a potent and oral selective inhibitor of γ-secretase (GSI), producing inhibitory activity of Notch 1–4… 
2012
2012
Morphologic and Functional Effects of Gamma Secretase Inhibition on Splenic Marginal Zone B Cells
The γ-secretase complex is a promising target in Alzheimer's disease because of its role in the amyloidogenic processing of… 
2012
2012
A phase II study of RO4929097 (RO), a gamma-secretase inhibitor, in advanced platinum (Pt)-resistant (R) ovarian cancer (OC): A study of the PMH, Chicago, and California phase II consortia.
5019 Background: Notch signalling pathway plays a critical role in regulating cellular differentiation, proliferation, and… 
2011
2011
Validation and implementation of a liquid chromatography/tandem mass spectrometry assay for quantitation of the total and unbound RO4929097, a γ-secretase inhibitor targeting Notch signaling, in…
2011
2011
Phase II study of RO4929097 in metastatic colorectal cancer.
e14058 Background: The Notch pathway is activated in colorectal cancer. Downstream signaling is mediated via cleavage of… 
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