RO 4929097

Known as: Gamma-Secretase Inhibitor RO4929097, RO-4929097, RO4929097 
An orally bioavailable, small-molecule gamma secretase (GS) inhibitorwith potential antitumor activity. Gamma secretase inhibitor RO4929097 binds to… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

2009-2017
0246820092017

Papers overview

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2014
2014
Retinal damage in teleosts, unlike mammals, induces robust Müller glia-mediated regeneration of lost neurons. We examined whether… (More)
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2013
2013
Purpose To establish the recommended phase II dose of the oral γ-secretase inhibitor RO4929097 (RO) in combination with… (More)
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2013
2013
Background:The Notch signalling pathway has been implicated in tumour initiation, progression, angiogenesis and development of… (More)
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Highly Cited
2012
Highly Cited
2012
PURPOSE To determine the maximum-tolerated dose (MTD) and assess safety, pharmacokinetics, pharmacodynamics, and evidence of… (More)
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2012
2012
BACKGROUND The Notch signalling pathway is activated in a variety of malignancies and has been implicated in colorectal cancer… (More)
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2012
2012
Basal breast cancer, common among patients presenting with inflammatory breast cancer (IBC), has been shown to be resistant to… (More)
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2012
2012
RO4929097 is a potent and selective inhibitor of γ-secretase and as a result is able to inhibit Notch pathway signaling. The… (More)
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2011
2011
Several reports have demonstrated a role for aberrant NOTCH signaling in melanoma genesis and progression, prompting us to… (More)
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2011
2011
Interest continues to build around the early application of patient selection markers to prospectively identify patients likely… (More)
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Highly Cited
2009
Highly Cited
2009
Notch signaling is an area of great interest in oncology. RO4929097 is a potent and selective inhibitor of gamma-secretase… (More)
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