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RO 4929097

Known as: Gamma-Secretase Inhibitor RO4929097, RO-4929097, RO4929097 
An orally bioavailable, small-molecule gamma secretase (GS) inhibitorwith potential antitumor activity. Gamma secretase inhibitor RO4929097 binds to… Expand
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2016
2016
Glioblastoma multiforme (GBM) is the most common malignant brain tumor in adults. The current standard of care includes surgery… Expand
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Highly Cited
2014
Highly Cited
2014
Retinal damage in teleosts, unlike mammals, induces robust Müller glia-mediated regeneration of lost neurons. We examined whether… Expand
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Highly Cited
2014
Highly Cited
2014
SummaryPurpose The notch pathway is overexpressed in pancreatic adenocarcinoma. RO4929097, an oral inhibitor of the γ-secretase… Expand
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2014
2014
Glioblastoma is the most common malignant primary brain tumor. Temozolomide (TMZ) is the standard chemotherapeutic agent for this… Expand
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Review
2013
Review
2013
The Notch signaling pathway is evolutionarily conserved and responsible for cell fate determination in the developing embryo and… Expand
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2013
2013
SummaryPurpose To establish the recommended phase II dose of the oral γ-secretase inhibitor RO4929097 (RO) in combination with… Expand
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2013
2013
Background:The Notch signalling pathway has been implicated in tumour initiation, progression, angiogenesis and development of… Expand
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Highly Cited
2012
Highly Cited
2012
BACKGROUND The Notch signalling pathway is activated in a variety of malignancies and has been implicated in colorectal cancer… Expand
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Highly Cited
2012
Highly Cited
2012
PURPOSE To determine the maximum-tolerated dose (MTD) and assess safety, pharmacokinetics, pharmacodynamics, and evidence of… Expand
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2011
2011
Several reports have demonstrated a role for aberrant NOTCH signaling in melanoma genesis and progression, prompting us to… Expand
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