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RNA splicing, via transesterification reactions with bulged adenosine as nucleophile

Splicing of RNA via a series of two transesterification reactions with a bulged adenosine residue from the intron branch point as the initiating… 
National Institutes of Health

Papers overview

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2017
2017
Modular Construction of Protected 1,2/1,3-Diols, -Amino Alcohols, and -Diamines via Catalytic Asymmetric Dehydrative Allylation: An Application to Synthesis of Sphingosine.
A new enantioselective catalysis has been developed for the one-step construction of methylene-bridged chiral modules of 1,2- and… 
2013
2013
Allylic C-H alkylation with a CF3-containing nucleophile.
Allylic C-H alkylation of allylarenes with dimethyl 2-trifluoromethylmalonate was successfully developed. The reactions were… 
2010
2010
Heteroatom-nucleophile-induced C-C fragmentations: synthesis of allenes and entry to domino reactions.
Heteroatom nucleophiles (NuH) induce Grob-type fragmentations of cyclic vinyl triflates under mild conditions and provide… 
2008
2008
Electrophilic C12 building blocks for alkaloids: formal total synthesis of (+/-)-maritidine.
Silyl-protected benzyl alcohol derivatives and the salt 1 are used to form ortho-substituted C12 electrophilic organoiron… 
2008
2008
Biological Effects of and Responses to Exposure to Electrophilic Environmental Chemicals
Electrophiles readily bind to nucleophilic centers on intracellular macromolecules such as DNA and proteins. Electrophilic attack… 
2008
2008
A scalable synthesis of an azabicyclooctanyl derivative, a novel DPP-4 inhibitor.
A practical synthetic strategy to a chiral azabicycclooctanyl derivative (1), a potent DPP-4 inhibitor, starting from a… 
2008
2008
Determining the transition-state structure for different SN2 reactions using experimental nucleophile carbon and secondary alpha-deuterium kinetic isotope effects and theory.
Nucleophile (11)C/ (14)C [ k (11)/ k (14)] and secondary alpha-deuterium [( k H/ k D) alpha] kinetic isotope effects (KIEs) were… 
2000
2000
Three- to six-carbon ring-enlargement reaction of cyclic ortho esters bearing a diazocarbonyl side chain. Use of the intramolecular formation of tricyclooxonium ylides
Two types of bicyclic ortho esters 14 and 18, which are tethered to a diazocarbonyl group by polymethylene linkages--(CH2)n--of… 
2000
2000
Ring-expansion of thioacetal ring via bicyclosulfonium ylide. Effect Of protic nucleophile on ylide intermediate
The reaction of 2-(3-diazo-2-oxopropane-1-yl)-2-methyldithiolane 9a, 2-(4-diazo-3-oxobutane-2-yl)-2-methyldithiolane 9c, and 2-(3… 
1998
1998
Camptothecins inhibit the utilization of hydrogen peroxide in the ligation step of topoisomerase I catalysis.
The antitumor compounds camptothecin and its derivatives topotecan and irinotecan stabilize topoisomerase I cleavage complexes by… 
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