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RHPP+

National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2015
Review
2015
[The neurotoxicity of pyridinium metabolites of haloperidol].
Haloperydol is a butyrophenone, typical neuroleptic agent characterized as a high antipsychotics effects in the treatment of… 
Review
1999
Review
1999
Enzyme-catalyzed bioactivation of cyclic tertiary amines to form potential neurotoxins.
The pyridinium metabolites formed in the MAO-B catalyzed oxidation of 1-methyl-4-substituted-1,2,3,6-tetrahydropyridinyl… 
1997
1997
Two pyridinium metabolites of haloperidol are present in the brain of patients at post-mortem.
1996
1996
Haloperidol and its tetrahydropyridine derivative (HPTP) are metabolized to potentially neurotoxic pyridinium species in the baboon.
1996
1996
Formation of pyridinium species of haloperidol in human liver and brain
Recent interest in the neurotoxicity of haloperidol is based on its oxidation in rodents to the pyridinium derivative, HPP+, a… 
1994
1994
Metabolic studies on haloperidol and its tetrahydropyridine analog in C57BL/6 mice.
The neuroleptic agent haloperidol (HP) is biotransformed in humans to a pyridinium metabolite, HPP+, that displays neurotoxic… 
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