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RHEB gene

Known as: RHEB2, FORMERLY, Ras homolog enriched in brain, RAS HOMOLOG ENRICHED IN BRAIN 2, FORMERLY 
This gene plays a role in the regulation of MTORC1-dependent signaling.
National Institutes of Health

Related topics

Related topics

7 relations
GTP BindingHomo sapiensRHEBL1 geneRHEBP1 gene

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
Characterization of a Variant of Tuberous Sclerosis Complex 2 and its Interaction with Rheb
Protein-protein interactions are vital in maintaining proper function and homeostasis in cells. Some signaling pathways are… 
2018
2018
Determination of mTORC1 Complex Structures Reveals Regulatory Mechanisms.
RHEB promotes allosteric activation of mTOR whereas PRAS40 blocks substrate recruitment sites. 
2017
2017
Abstract 329: Selinexor or KPT-8602 mediated XPO1 inhibition synergizes with dexamethasone to repress convergent pathways in the mTORC1 signaling network and drive cell death in multiple myeloma
Background: Dexamethasone (DEX), a synthetic glucocorticoid (GC), is administered to nearly all multiple myeloma (MM) patients as… 
2013
2013
Functional Analysis of the RHEB Promoter
The small GTPase Rheb has been found to be overexpressed in some tumors, and its overexpression is thought to promote tumor… 
2012
2012
Creation of a mouse model with consitutively activated RHEB (RAS Homologue enriched in brain) in adipose tissue
2011
2011
Rheb: Enrichment beyond the brain
Comment on: Goorden SM, et al. Mol Cell Biol 2011; 31:1672-8. 
2009
2009
Activation of mTORC 1 in two steps : Rheb-GTP activation of catalytic function and increased binding of substrates to raptor 1
The signalling function of mTOR complex 1 is activated by Rheb-GTP, which controls the catalytic competence of the mTOR… 
2006
2006
TITLE : A Genetic Approach to Define the Importance of Rheb in Tuberous Sclerosis PRINCIPAL INVESTIGATOR :
2006
2006
The mTOR pathway integrates the glucose sufficiency through an interaction between Rheb and glyceraldehyde-3-phosphate dehydrogenase
2006
2006
A Genetic Approach to Define the Importance of Rheb in Tuberous Sclerosis
Abstract : This report summarizes our accomplishments in characterizing the TSC/Rheb/mTOR signaling pathway that is altered in…