RG7112
National Institutes of Health
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Purpose: p53 pathway alterations are key molecular events in glioblastoma (GBM). MDM2 inhibitors increase expression and…
BACKGROUND
Approaches in disruption of MDM2-p53 interactions have now emerged as an important therapeutic strategy in…
Background: Acute myeloid leukemia (AML) is characterized by the clonal expansion of immature myeloid cells. AML is treated…
Background Activation of the p53 pathway through inhibition of its negative regulator MDM2 is a promising strategy for cancer…
MDM2 is overproduced as a mechanism to impair p53 function in many cancers. By reactivating p53, antagonists of p53-MDM2…
Abstract 675
Background: Activation of the p53 pathway by inhibition of its negative regulator MDM2 has been proposed as a…
The Philadelphia chromosome negative myeloproliferative neoplasms (MPN) originate at the level of the pluripotent hematopoietic…
10007b Background: WD/DD LPS are a prominent subset (15%) of sarcomas, where cytotoxic treatments have limited activity. MDM2…
Abstract 1545 Background: The tumor suppressor p53 plays a critical role in protecting cells from malignant transformation by…