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Mouse REC114 is essential for meiotic DNA double-strand break formation and forms a complex with IHO1. Its N-terminal region… Expand Meiotic recombination is an essential biological process that generates genetic diversity and ensures proper segregation of… Expand An essential feature of meiosis is Spo11 catalysis of programmed DNA double strand breaks (DSBs). Evidence suggests that the… Expand During gamete formation, crossover recombination must occur on replicated DNA to ensure proper chromosome segregation in the… Expand Meiotic recombination is initiated by the programmed induction of DNA double-strand breaks (DSBs) catalyzed by the evolutionarily… Expand In most sexually reproducing organisms, meiotic recombination is initiated by DNA double-strand breaks (DSBs) formed by the Spo11… Expand Meiotic recombination is initiated by DNA double-stranded break (DSB) formation catalyzed by Spo11, a type-II topoisomerase-like… Expand In budding yeast, at least 10 proteins are required for formation of the double-strand breaks (DSBs) that initiate meiotic… Expand DMC1, the meiosis‐specific eukaryotic homologue of bacterial recA, is required for completion of meiotic recombination and cell… Expand REC114 is one of 10 genes known to be required for the initiation of meiotic recombination in Saccharomyces cerevisiae. It is… Expand