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WEE1 regulates the cell cycle by inactivating cyclin dependent protein kinases (CDKs) via phosphorylation. In yeast and animal… Expand BACKGROUND
Ras-extracellular signal-regulated kinase (Ras-ERK) signaling is central to the molecular machinery underlying… Expand NMDA-type glutamate receptors (NMDARs) contribute to many forms of long-term potentiation (LTP) and long-term depression (LTD… Expand BACKGROUND
Cell-cycle progression is tightly regulated during embryonic development. In the Drosophila early embryo, the levels… Expand Previous results have suggested that the Ras signaling pathway is involved in learning and memory. Ras is activated by nucleotide… Expand In previous studies we changed five conserved amino acid residues in the catalytic domain of the yeast Ras-specific guanine… Expand The levels of the B cyclin p56cdc13 and the phosphatase p80cdc25 have been followed in selection-synchronised cultures of… Expand The best characterized yeast guanine nucleotide releasing factor is CDC25, which acts on RAS and thereby stimulates cAMP… Expand A critical step in the activation of cellular Ras is the release of bound GDP. Oligonucleotide primers derived from a mouse cDNA… Expand In the yeast Saccharomyces cerevisiae, addition of glucose to cells grown under glucose-derepressed conditions induces a… Expand