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Sudden unexplained nocturnal death syndrome (SUNDS) remains an enigma to both forensic pathologists and physicians. Previous… Expand Background—Loss-of-function mutations in Nav1.5 cause sodium channelopathies, including Brugada syndrome, dilated cardiomyopathy… Expand BACKGROUND
Brugada syndrome (BrS) is a primary arrhythmia syndrome characterized by the occurrence of malignant ventricular… Expand Background— Brugada syndrome (BrS) is caused mainly by mutations in the SCN5A gene, which encodes the &agr;-subunit of the… Expand BACKGROUND
The protein MOG1 is a cofactor of the cardiac sodium channel, Nav1.5. Overexpression of MOG1 in Nav1.5-expressing… Expand The cardiac sodium channel Nav1.5 is essential for the physiological function of the heart and contributes to lethal cardiac… Expand Many of the proteins that mediate transport into and out of the nucleus have been structurally and functionally conserved… Expand Mog1 is a nuclear protein that interacts with Ran, the Ras family GTPase that confers directionality to nuclear import and export… Expand We have cloned and characterized the Schizosaccharomyces pombe gene mog1(+), which encodes a protein with homology to the… Expand We previously isolated 25 temperature-sensitive gsp1 alleles of Saccharomyces cerevisiae Ran homologue, each of which possesses… Expand