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R2TP complex

Known as: R2TP complex location 
A highly conserved protein complex comprised of two ATP-dependent DNA helicases (Rvb1p and Rvb2p in yeast, Pontin52 and Reptin52 in humans), Pih1p in… 
National Institutes of Health

Papers overview

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2019
2019
The R2TP complex regulates paramyxovirus RNA synthesis
The regulation of paramyxovirus RNA synthesis by host proteins is poorly understood. Here, we identified a novel regulation… 
2018
2018
Advances on the Structure of the R2TP/Prefoldin-like Complex.
Cellular stability, assembly and activation of a growing list of macromolecular complexes require the action of HSP90 working in… 
2017
2017
Axonemal dynein assembly requires the R2TP complex component Pontin
Pontin (Ruvbl1) and Reptin (Ruvbl2) are closely related AAA ATPases. They are components of the Ruvbl1-Ruvbl2-Tah1-Pih1 (R2TP… 
Review
2016
Review
2016
Assembly and trafficking of box C/D and H/ACA snoRNPs
ABSTRACT Box C/D and box H/ACA snoRNAs are abundant non-coding RNAs that localize in the nucleolus and mostly function as guides… 
Review
2015
Review
2015
Substrate recognition and function of the R2TP complex in response to cellular stress
The R2TP complex is a HSP90 co-chaperone, which consists of four subunits: PIH1D1, RPAP3, RUVBL1, and RUVBL2. It is involved in… 
2015
2015
A Novel Interaction of Ecdysoneless (ECD) Protein with R2TP Complex Component RUVBL1 Is Required for the Functional Role of ECD in Cell Cycle Progression
ABSTRACT Ecdysoneless (ECD) is an evolutionarily conserved protein whose germ line deletion is embryonic lethal. Deletion of Ecd… 
2015
2015
Structure/Function Analysis of Protein-Protein Interactions Developed by the Yeast Pih1 Platform Protein and Its Partners in Box C/D snoRNP Assembly.
2013
2013
High-resolution structural analysis shows how Tah1 tethers Hsp90 to the R2TP complex.
Review
2012
Review
2012
The R2TP complex: discovery and functions.
Highly Cited
2008
Highly Cited
2008
Molecular chaperone Hsp90 stabilizes Pih1/Nop17 to maintain R2TP complex activity that regulates snoRNA accumulation
Hsp90 is a highly conserved molecular chaperone that is involved in modulating a multitude of cellular processes. In this study… 
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