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R1479

National Institutes of Health

Papers overview

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Highly Cited
2018
Highly Cited
2018
Paramyxoviruses represent a family of RNA viruses causing significant human diseases. These include measles virus, the most… 
Highly Cited
2013
Highly Cited
2013
Background. Dengue is the most common arboviral infection of humans. There are currently no specific treatments for dengue… 
Highly Cited
2009
Highly Cited
2009
The discovery of 4'-azidocytidine (3) (R1479) (J. Biol. Chem. 2006, 281, 3793; Bioorg. Med. Chem. Lett. 2007, 17, 2570) as a… 
Highly Cited
2008
Highly Cited
2008
ABSTRACT Specific inhibitors of hepatitis C virus (HCV) replication that target the NS3/4A protease (e.g., VX-950) or the NS5B… 
Highly Cited
2008
Highly Cited
2008
OBJECTIVES To characterize the effect of hepatitis C virus (HCV) polymerase intrinsic genetic heterogeneity on the inhibitory… 
Highly Cited
2008
Highly Cited
2008
The nucleoside analog R1479 is a potent and highly selective inhibitor of nonstructural protein 5B–directed hepatitis C virus… 
Highly Cited
2008
Highly Cited
2008
RNA polymerases effectively discriminate against deoxyribonucleotides and specifically recognize ribonucleotide substrates most… 
Highly Cited
2008
Highly Cited
2008
R1626, a prodrug of the hepatitis C virus (HCV) RNA polymerase inhibitor R1479, showed time‐dependent and dose‐dependent… 
Highly Cited
2006
Highly Cited
2006
Hepatitis C virus (HCV) polymerase activity is essential for HCV replication. Targeted screening of nucleoside analogs identified…