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R1479

 
National Institutes of Health

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2017
2017
The henipaviruses Nipah virus and Hendra virus are highly pathogenic zoonotic paramyxoviruses which have caused fatal outbreaks… Expand
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Highly Cited
2013
Highly Cited
2013
BACKGROUND Dengue is the most common arboviral infection of humans. There are currently no specific treatments for dengue… Expand
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2009
2009
We report the design, synthesis and evaluation of a family of ca 50 phosphoramidate ProTides of the potent anti-HCV compound 4… Expand
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Highly Cited
2008
Highly Cited
2008
OBJECTIVES To characterize the effect of hepatitis C virus (HCV) polymerase intrinsic genetic heterogeneity on the inhibitory… Expand
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Highly Cited
2008
Highly Cited
2008
Specific inhibitors of hepatitis C virus (HCV) replication that target the NS3/4A protease (e.g., VX-950) or the NS5B polymerase… Expand
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2008
2008
UNLABELLED R1626, a prodrug of the hepatitis C virus (HCV) RNA polymerase inhibitor R1479, showed time-dependent and dose… Expand
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2008
2008
UNLABELLED The nucleoside analog R1479 is a potent and highly selective inhibitor of nonstructural protein 5B-directed hepatitis… Expand
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2007
2007
A series of 4'-substituted ribonucleoside derivatives has been prepared and evaluated for inhibition of hepatitis C virus (HCV… Expand
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2007
2007
RNA polymerases effectively discriminate against deoxyribonucleotides and specifically recognize ribonucleotide substrates most… Expand
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Highly Cited
2006
Highly Cited
2006
Hepatitis C virus (HCV) polymerase activity is essential for HCV replication. Targeted screening of nucleoside analogs identified… Expand
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