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R1479

 
National Institutes of Health

Papers overview

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2017
2017
The henipaviruses Nipah virus and Hendra virus are highly pathogenic zoonotic paramyxoviruses which have caused fatal outbreaks… Expand
Highly Cited
2013
Highly Cited
2013
Background. Dengue is the most common arboviral infection of humans. There are currently no specific treatments for dengue… Expand
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2009
2009
We report the design, synthesis and evaluation of a family of ca 50 phosphoramidate ProTides of the potent anti-HCV compound 4… Expand
Highly Cited
2008
Highly Cited
2008
ABSTRACT Specific inhibitors of hepatitis C virus (HCV) replication that target the NS3/4A protease (e.g., VX-950) or the NS5B… Expand
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Highly Cited
2008
Highly Cited
2008
OBJECTIVES To characterize the effect of hepatitis C virus (HCV) polymerase intrinsic genetic heterogeneity on the inhibitory… Expand
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Highly Cited
2008
Highly Cited
2008
The nucleoside analog R1479 is a potent and highly selective inhibitor of nonstructural protein 5B–directed hepatitis C virus… Expand
Highly Cited
2008
Highly Cited
2008
R1626, a prodrug of the hepatitis C virus (HCV) RNA polymerase inhibitor R1479, showed time‐dependent and dose‐dependent… Expand
Highly Cited
2007
Highly Cited
2007
A series of 4'-substituted ribonucleoside derivatives has been prepared and evaluated for inhibition of hepatitis C virus (HCV… Expand
Highly Cited
2006
Highly Cited
2006
Hepatitis C virus (HCV) polymerase activity is essential for HCV replication. Targeted screening of nucleoside analogs identified… Expand
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Highly Cited
2006
Highly Cited
2006
The HCV polymerase is an attractive target for the development of new and specific anti-HCV drugs. Herein, the characterization… Expand
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