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R 848

Known as: R-848, R848 compound 
National Institutes of Health

Papers overview

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Highly Cited
2005
Highly Cited
2005
TLRs are involved in innate cell activation by conserved structures expressed by microorganisms. Human T cells express the mRNA… Expand
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Highly Cited
2005
Highly Cited
2005
TLR ligands that mimic pathogen associated molecular patterns and activate immune cells via Toll-like receptors (TLRs) are being… Expand
Highly Cited
2004
Highly Cited
2004
ABSTRACT In this study, we analyzed the phenotypic and physiological consequences of the interaction of plasmacytoid dendritic… Expand
Highly Cited
2003
Highly Cited
2003
Loxoribine (7‐allyl‐7,8‐dihydro‐8‐oxo‐guanosine) acts as synthetic adjuvant in anti‐tumor responses. Here we first demonstrate… Expand
Highly Cited
2003
Highly Cited
2003
Certain C8-substituted and N7, C8-disubstituted guanine ribonucleosides comprise a class of small molecules with… Expand
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Highly Cited
2002
Highly Cited
2002
Highly Cited
2002
The imidazoquinoline compounds imiquimod and R-848 are low-molecular-weight immune response modifiers that can induce the… Expand
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Highly Cited
2000
Highly Cited
2000
Imiquimod (R-837) and its more potent derivative (R-848) are imidazoquinolines that have adjuvant activity in cultured human… Expand
Highly Cited
2000
Highly Cited
2000
R-848 and imiquimod belong to a class of immune response modifiers that are potent inducers of cytokines, including IFN-alpha… Expand
Highly Cited
1999
Highly Cited
1999
Cytokines produced by antigen-presenting cells are known to affect the development and cytokine profile of T cells. The immune… Expand