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TLRs are involved in innate cell activation by conserved structures expressed by microorganisms. Human T cells express the mRNA… Expand TLR ligands that mimic pathogen associated molecular patterns and activate immune cells via Toll-like receptors (TLRs) are being… Expand ABSTRACT In this study, we analyzed the phenotypic and physiological consequences of the interaction of plasmacytoid dendritic… Expand Loxoribine (7‐allyl‐7,8‐dihydro‐8‐oxo‐guanosine) acts as synthetic adjuvant in anti‐tumor responses. Here we first demonstrate… Expand Certain C8-substituted and N7, C8-disubstituted guanine ribonucleosides comprise a class of small molecules with… Expand The imidazoquinoline compounds imiquimod and R-848 are low-molecular-weight immune response modifiers that can induce the… Expand Imiquimod (R-837) and its more potent derivative (R-848) are imidazoquinolines that have adjuvant activity in cultured human… Expand R-848 and imiquimod belong to a class of immune response modifiers that are potent inducers of cytokines, including IFN-alpha… Expand Cytokines produced by antigen-presenting cells are known to affect the development and cytokine profile of T cells. The immune… Expand