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R-2HMP

Known as: R-N-2-heptyl-N-methylpropargylamine 
 
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2002
Review
2002
Aliphatic propargylamines as symptomatic and neuroprotective treatments for neurodegenerative diseases.
Over the past several years, we have developed a number of novel aliphatic propargylamine-related compounds. These can be divided… Expand
2001
2001
Inhibition of rat liver microsomal CYP1A2 and CYP2B1 activity by N-(2-heptyl)-N-methyl-propargylamine and by N-(2-heptyl)-propargylamine.
  • L. Dyck, B. Davis
  • Drug metabolism and disposition: the biological…
  • 2001
    • Corpus ID: 11567189
(R)-N-(2-Heptyl)-N-methyl-propargylamine (R-2HMP) and (R)-N-(2-heptyl)-propargylamine (R-2HPA) are analogs of R-deprenyl. R… Expand
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Review
2001
Review
2001
Anti-apoptotic actions of R-2HMP in cerebellar granule cells : changes of mitochondrial membrane potential and sub-cellular GAPDH protein
(R)-N-(2-hepty1)-N-methyIpropargy1amine (R-2HMP) has been shown to reduce neuronal death through an action at the same site as R… Expand
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2000
2000
Metabolism and pharmacokinetics, in the rat, of (R)-N-(2-Heptyl)Methyl-propargylamine (R-2HMP), a new potent monoamine oxidase inhibitor and antiapoptotic agent.
(R)-N-(2-Heptyl)-N-methylpropargylamine (R-2HMP) is a monoamine oxidase inhibitor and putative antiapoptotic agent analogous to… Expand
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Review
2000
Review
2000
Common properties for propargylamines of enhancing superoxide dismutase and catalase activities in the dopaminergic system in the rat: implications for the life prolonging effect of (-)deprenyl.
(-)Deprenyl has been reported to prolong the life span of different animal species. Further, the drug effectively increases… Expand
Review
1999
Review
1999
Symptomatic and neuroprotective properties of the aliphatic propargylamines
  • A. Boulton
  • Mechanisms of Ageing and Development
  • 1999
    • Corpus ID: 39232669
This short review describes the development of several families of aliphatic propargylamine drugs. The parent family--the… Expand
1998
1998
Antiapoptotic actions of monoamine oxidase B inhibitors.
Publisher Summary R-Deprenyl is an irreversible inhibitor of monoamine oxidase (MAO) with selectivity for MAO-B and, believed to… Expand
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