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R-2HMP

Known as: R-N-2-heptyl-N-methylpropargylamine 
 

Topic mentions per year

Topic mentions per year

1999-2001
012319992001

Papers overview

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Review
2002
Review
2002
Aliphatic propargylamines as symptomatic and neuroprotective treatments for neurodegenerative diseases.
Over the past several years, we have developed a number of novel aliphatic propargylamine-related compounds. These can be divided… (More)
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2001
2001
Inhibition of rat liver microsomal CYP1A2 and CYP2B1 activity by N-(2-heptyl)-N-methyl-propargylamine and by N-(2-heptyl)-propargylamine.
(R)-N-(2-Heptyl)-N-methyl-propargylamine (R-2HMP) and (R)-N-(2-heptyl)-propargylamine (R-2HPA) are analogs of R-deprenyl. R… (More)
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2000
2000
Metabolism and pharmacokinetics, in the rat, of (R)-N-(2-Heptyl)Methyl-propargylamine (R-2HMP), a new potent monoamine oxidase inhibitor and antiapoptotic agent.
(R)-N-(2-Heptyl)-N-methylpropargylamine (R-2HMP) is a monoamine oxidase inhibitor and putative antiapoptotic agent analogous to… (More)
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Review
2000
Review
2000
Common properties for propargylamines of enhancing superoxide dismutase and catalase activities in the dopaminergic system in the rat: implications for the life prolonging effect of (-)deprenyl.
(-)Deprenyl has been reported to prolong the life span of different animal species. Further, the drug effectively increases… (More)
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1999
1999
Loss of mitochondrial membrane potential is dependent on the apoptotic program activated: prevention by R-2HMP.
Recent evidence suggests that the mitochondrial membrane potential begins to decrease well before the cells commit to apoptotic… (More)
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Review
1999
Review
1999
R-2HMP: an Orally Active Agent Combining Independent Antiapoptotic and MAO-B-Inhibitory Activities
During the past decade, much interest has been focused on the potential utility of monoamine oxidase (MAO) type B inhibitors in… (More)
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Review
1999
Review
1999
Symptomatic and neuroprotective properties of the aliphatic propargylamines.
This short review describes the development of several families of aliphatic propargylamine drugs. The parent family--the… (More)
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