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R 115866

Known as: R-115866, R115866 
National Institutes of Health

Related topics

Related topics

5 relations

Broader (3)

BenzothiazolesCytochrome P-450 Enzyme InhibitorsTriazoles

Narrower (1)

Rambazole
talarozole

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2012
2012
Homology Models of Human All-Trans Retinoic Acid Metabolizing Enzymes CYP26B1 and CYP26B1 Spliced Variant
Homology models of CYP26B1 (cytochrome P450RAI2) and CYP26B1 spliced variant were derived using the crystal structure of… 
2010
2010
CYP26A1-specific antagonist influence on embryonic implantation, gene expression and endogenous retinoid concentration in rats.
2010
2010
CYP 26 B 1 Plays a Major Role in the Regulation of All-trans-Retinoic Acid Metabolism and Signaling in Human Aortic Smooth Muscle Cells
Aim: The cytochrome P450 enzymes of the CYP26 family are involved in the catabolism of the biologically active retinoid alltrans… 
2009
2009
Topical treatment with CYP26 inhibitor talarozole (R115866) dose dependently alters the expression of retinoid‐regulated genes in normal human epidermis
Background  An alternative approach to retinoid therapy is to inhibit the cytochrome P450 (CYP)‐mediated catabolism of endogenous… 
2008
2008
Homology Models and Molecular Modeling of Human Retinoic Acid Metabolizing Enzymes Cytochrome P450 26A1 (CYP26A1) and P450 26B1 (CYP26B1).
Homology models of cytochrome P450 26A1 and cytochrome P450 26B1 were constructed using the crystal structures of human, CYP2C8… 
2008
2008
Oral R115866 in the treatment of moderate to severe plaque-type psoriasis
2007
2007
Oral R115866 in the treatment of moderate to severe plaque‐type psoriasis
Background  R115866 (RambazoleTM) is a new generation all‐trans retinoic acid metabolism blocking agent, highly specific against… 
2007
2007
Oral R115866 in the treatment of moderate to severe facial acne vulgaris: an exploratory study
Background  R115866 (RambazoleTM; Barrier Therapeutics NV, Geel, Belgium), a new‐generation retinoic acid metabolism‐blocking… 
2007
2007
CYP26 Inhibitor R115866 Increases Retinoid Signaling in Intimal Smooth Muscle Cells
Objective—Intimal smooth muscle cells (SMCs) are dedifferentiated SMCs that have a powerful ability to proliferate and migrate… 
2005
2005
Novel tetralone-derived retinoic acid metabolism blocking agents: synthesis and in vitro evaluation with liver microsomal and MCF-7 CYP26A1 cell assays.
The potent inhibitory activity of novel 2-benzyltetralone and 2-benzylidenetetralone derivatives vs liver microsomal retinoic… 
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