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R-(-)-Gossypol Acetic Acid

Known as: (-)-Gossypol Acetic Acid, (2,2'-Binaphthalene)-8,8'-dicarboxaldehyde, 1,1',6,6',7,7'-hexahydroxy-3,3'-dimethyl-(R)-5,5'-bis(1-methylethyl)-, (2R)-, compd. with acetic acid (1:1), GOSSYPOL ACETIC ACID, (R)- 
The orally bioavailable solvate of the R-(-) enantiomer of gossypol and acetic acid with potential antineoplastic activity. As a BH3 mimetic, R… 
National Institutes of Health

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gossypol acetic acid

Papers overview

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2015
2015
Correction: BNIP3 Regulates AT101 [(-)-Gossypol] Induced Death in Malignant Peripheral Nerve Sheath Tumor Cells
There is an error in Fig 1. In Fig 1C, the y-axis should read: “Percentage of ethidium homodimer-1 positive dead cells.” Please… 
2012
2012
A validated HPLC assay for the determination of R-(-)-gossypol in human plasma and its application in clinical pharmacokinetic studies.
2010
2010
A phase I study of R-(-)-gossypol (AT-101) in combination with cisplatin (P) and etoposide (E) in patients with advanced solid tumors and extensive-stage small cell lung cancer (ES-SCLC).
e13502 Background: AT-101 [R-(-)-gossypol acetic acid] (AT) is an orally-administered BH3 mimetic that lowers the threshold for… 
2010
2010
Phase II trial of R-(-)-gossypol acetic acid (NSC 726190, AT-101) in patients with recurrent extensive stage small cell lung cancer (ES-SCLC).
e17523 Background: AT-101 is an oral inhibitor of the anti-apoptotic Bcl proteins (Bcl-2, Bcl-XL, Bcl-W, and Mcl-1) and potent… 
2004
2004
Cytotoxicity of enantiomers of gossypol Schiff's bases and optical stability of gossypolone.
2000
2000
Chiral separation of the enantiomers of metoprolol and its metabolites by high performance liquid chromatography
Abstract(1′R, 2R)-, (1′R, 2S)-, (1′S, 2R)- and (1′S, 2S)-α-hydroxymetoprolol; (2R)- and (2S)-O-desmethylmetoprolol; and (2R)- and… 
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