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R-(-)-Gossypol Acetic Acid

Known as: (-)-Gossypol Acetic Acid, (2,2'-Binaphthalene)-8,8'-dicarboxaldehyde, 1,1',6,6',7,7'-hexahydroxy-3,3'-dimethyl-(R)-5,5'-bis(1-methylethyl)-, (2R)-, compd. with acetic acid (1:1), GOSSYPOL ACETIC ACID, (R)- 
The orally bioavailable solvate of the R-(-) enantiomer of gossypol and acetic acid with potential antineoplastic activity. As a BH3 mimetic, R… Expand
National Institutes of Health

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gossypol acetic acid

Papers overview

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2014
2014
Hsp90 inhibitor 17-AAG sensitizes Bcl-2 inhibitor (-)-gossypol by suppressing ERK-mediated protective autophagy and Mcl-1 accumulation in hepatocellular carcinoma cells.
Natural BH3-memitic (-)-gossypol shows promising antitumor efficacy in several kinds of cancer. However, our previous studies… Expand
2012
2012
A validated HPLC assay for the determination of R-(-)-gossypol in human plasma and its application in clinical pharmacokinetic studies.
R-(-)-gossypol acetic acid (AT-101), a natural BH3 mimetic, is investigated in a Phase I/II clinical trial for the treatment of… Expand
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2011
2011
Sorafenib Sensitizes (−)-Gossypol-Induced Growth Suppression in Androgen-Independent Prostate Cancer Cells via Mcl-1 Inhibition and Bak Activation
The natural BH3-mimetic (−)-gossypol shows promising efficacy in ongoing phase II/III clinical trials for human prostate cancer… Expand
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2010
2010
The Bcl-2-Beclin 1 interaction in (-)-gossypol-induced autophagy versus apoptosis in prostate cancer cells.
Bcl-2 is a key dual regulator of autophagy and apoptosis, but how the level of Bcl-2 influences the cellular decision between… Expand
2010
2010
AT‐101 (R‐(−)‐gossypol acetic acid) enhances the effectiveness of androgen deprivation therapy in the VCaP prostate cancer model
Prostate cancer remains a leading cause of cancer death in American men. Androgen deprivation therapy (ADT) is the most common… Expand
2008
2008
New Acetylenic Norlignan Compounds from Rhizomes of Curculigo crassifolia
Two pairs of diastereoisomeric acetylenic norlignan compounds with PhCH(OR1)CH(OR2)CH2C≡CPh skeleta: (1R, 2R)-1-O… Expand
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2007
2007
In vivo evaluation of AT-101 (R-(-)-gossypol acetic acid) in androgen-independent growth of VCaP prostate cancer cells in combination with surgical castration.
PURPOSE Upregulation of Bcl-2 family members is a well-established mechanism in the development of androgen-independent prostate… Expand
2004
2004
Cytotoxicity of enantiomers of gossypol Schiff's bases and optical stability of gossypolone.
Optical Schiff's bases of gossypol were prepared with chiral gossypol and ethylamine. As has been similarly observed among the… Expand
2002
2002
Gossypol and gossypolone enantiomers in tissues of rainbow trout fed low and high levels of dietary cottonseed meal.
Gossypol is an antifertilizing agent in males and females. However, gossypol and its metabolite, gossypolone, have also gained… Expand
2000
2000
Chiral separation of the enantiomers of metoprolol and its metabolites by high performance liquid chromatography
Abstract(1′R, 2R)-, (1′R, 2S)-, (1′S, 2R)- and (1′S, 2S)-α-hydroxymetoprolol; (2R)- and (2S)-O-desmethylmetoprolol; and (2R)- and… Expand
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