Skip to search formSkip to main content
You are currently offline. Some features of the site may not work correctly.

R-(-)-Gossypol Acetic Acid

Known as: (-)-Gossypol Acetic Acid, (2,2'-Binaphthalene)-8,8'-dicarboxaldehyde, 1,1',6,6',7,7'-hexahydroxy-3,3'-dimethyl-(R)-5,5'-bis(1-methylethyl)-, (2R)-, compd. with acetic acid (1:1), GOSSYPOL ACETIC ACID, (R)- 
The orally bioavailable solvate of the R-(-) enantiomer of gossypol and acetic acid with potential antineoplastic activity. As a BH3 mimetic, R… Expand
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2014
2014
Natural BH3-memitic (-)-gossypol shows promising antitumor efficacy in several kinds of cancer. However, our previous studies… Expand
2012
2012
R-(-)-gossypol acetic acid (AT-101), a natural BH3 mimetic, is investigated in a Phase I/II clinical trial for the treatment of… Expand
  • table 2
  • table 3
2011
2011
The natural BH3-mimetic (−)-gossypol shows promising efficacy in ongoing phase II/III clinical trials for human prostate cancer… Expand
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
2010
2010
Bcl-2 is a key dual regulator of autophagy and apoptosis, but how the level of Bcl-2 influences the cellular decision between… Expand
2010
2010
Prostate cancer remains a leading cause of cancer death in American men. Androgen deprivation therapy (ADT) is the most common… Expand
2008
2008
Two pairs of diastereoisomeric acetylenic norlignan compounds with PhCH(OR1)CH(OR2)CH2C≡CPh skeleta: (1R, 2R)-1-O… Expand
  • table 1
  • figure 1
  • table 2
2007
2007
PURPOSE Upregulation of Bcl-2 family members is a well-established mechanism in the development of androgen-independent prostate… Expand
2004
2004
Optical Schiff's bases of gossypol were prepared with chiral gossypol and ethylamine. As has been similarly observed among the… Expand
2002
2002
Gossypol is an antifertilizing agent in males and females. However, gossypol and its metabolite, gossypolone, have also gained… Expand
2000
2000
Abstract(1′R, 2R)-, (1′R, 2S)-, (1′S, 2R)- and (1′S, 2S)-α-hydroxymetoprolol; (2R)- and (2S)-O-desmethylmetoprolol; and (2R)- and… Expand
  • figure 1