R-(-)-Gossypol Acetic Acid

Known as: (-)-Gossypol Acetic Acid, (2,2'-Binaphthalene)-8,8'-dicarboxaldehyde, 1,1',6,6',7,7'-hexahydroxy-3,3'-dimethyl-(R)-5,5'-bis(1-methylethyl)-, (2R)-, compd. with acetic acid (1:1), GOSSYPOL ACETIC ACID, (R)-

The orally bioavailable solvate of the R-(-) enantiomer of gossypol and acetic acid with potential antineoplastic activity. As a BH3 mimetic, R… (More)

National Institutes of Health

Papers overview

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2012

2012

Sorafenib sensitizes (-)-gossypol-induced growth suppression in androgen-independent prostate cancer cells via Mcl-1 inhibition and Bak activation.

Jiqin Lian, Zhenhong Ni, +4 authors Feng-tian He
Molecular cancer therapeutics
2012

The natural BH3-mimetic (-)-gossypol shows promising efficacy in ongoing phase II/III clinical trials for human prostate cancer… (More)

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2012

2012

A validated HPLC assay for the determination of R-(-)-gossypol in human plasma and its application in clinical pharmacokinetic studies.

Hongxia Lin, Murugesan K. Gounder, Joseph R. Bertino, Ah-Ng. Tony Kong, Robert S. DiPaola, Mark N. Stein
Journal of pharmaceutical and biomedical analysis
2012

R-(-)-gossypol acetic acid (AT-101), a natural BH3 mimetic, is investigated in a Phase I/II clinical trial for the treatment of… (More)

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2010

2010

AT-101 (R-(-)-gossypol acetic acid) enhances the effectiveness of androgen deprivation therapy in the VCaP prostate cancer model.

Natalie A McGregor, Lalit R. Patel, Matthew E Craig, Savannah Weidner, Shaomeng Wang, Kenneth J. Pienta
Journal of cellular biochemistry
2010

Prostate cancer remains a leading cause of cancer death in American men. Androgen deprivation therapy (ADT) is the most common… (More)

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2008

2008

New acetylenic norlignan compounds from rhizomes of Curculigo crassifolia.

Kai-jin Wang, Ning Li, Hu Wang
Molecules
2008

Two pairs of diastereoisomeric acetylenic norlignan compounds with PhCH(OR(1))CH(OR(2))CH(2)C triple bond CPh skeleta: (1R, 2R)-1… (More)

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2007

2007

In vivo evaluation of AT-101 (R-(-)-gossypol acetic acid) in androgen-independent growth of VCaP prostate cancer cells in combination with surgical castration.

Robert D. Loberg, Natalie A McGregor, Chi C. Ying, Erin Sargent, Kenneth J. Pienta
Neoplasia
2007

PURPOSE Upregulation of Bcl-2 family members is a well-established mechanism in the development of androgen-independent prostate… (More)

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2006

2006

Molecular mechanisms of (-)-gossypol-induced apoptosis in human prostate cancer cells.

Yi-Wen Huang, Li-shu Wang, +4 authors Young C. Lin
Anticancer research
2006

BACKGROUND Gossypol, a natural compound present in cottonseeds, displays antiproliferative and pro-apoptotic effects against… (More)

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2006

2006

The peroxidative coupling of hemigossypol to (+)- and (-)-gossypol in cottonseed extracts.

Chauncey R Benedict, Jinggao Liu, Robert D Stipanovic
Phytochemistry
2006

Peroxidase(s) present in embryo extracts of Gossypium hirsutum cv. Texas Marker 1 catalyzed a bimolecular coupling of [4-(3)H… (More)

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