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R-(-)-Gossypol Acetic Acid
Known as:
(-)-Gossypol Acetic Acid
, (2,2'-Binaphthalene)-8,8'-dicarboxaldehyde, 1,1',6,6',7,7'-hexahydroxy-3,3'-dimethyl-(R)-5,5'-bis(1-methylethyl)-, (2R)-, compd. with acetic acid (1:1)
, GOSSYPOL ACETIC ACID, (R)-
The orally bioavailable solvate of the R-(-) enantiomer of gossypol and acetic acid with potential antineoplastic activity. As a BH3 mimetic, R…
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National Institutes of Health
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gossypol acetic acid
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2015
2015
Correction: BNIP3 Regulates AT101 [(-)-Gossypol] Induced Death in Malignant Peripheral Nerve Sheath Tumor Cells
Niroop Kaza
,
Latika Kohli
,
Christopher D. Graham
,
B. Klocke
,
S. Carroll
,
K. Roth
PLoS ONE
2015
Corpus ID: 6284204
There is an error in Fig 1. In Fig 1C, the y-axis should read: “Percentage of ethidium homodimer-1 positive dead cells.” Please…
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2012
2012
A validated HPLC assay for the determination of R-(-)-gossypol in human plasma and its application in clinical pharmacokinetic studies.
Hongxia Lin
,
M. Gounder
,
J. Bertino
,
A. Kong
,
R. DiPaola
,
M. Stein
Journal of Pharmaceutical and Biomedical Analysis
2012
Corpus ID: 5098442
2010
2010
A phase I study of R-(-)-gossypol (AT-101) in combination with cisplatin (P) and etoposide (E) in patients with advanced solid tumors and extensive-stage small cell lung cancer (ES-SCLC).
T. Leal
,
W. Schelman
,
+5 authors
G. Wilding
Journal of Clinical Oncology
2010
Corpus ID: 21064288
e13502 Background: AT-101 [R-(-)-gossypol acetic acid] (AT) is an orally-administered BH3 mimetic that lowers the threshold for…
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2010
2010
Phase II trial of R-(-)-gossypol acetic acid (NSC 726190, AT-101) in patients with recurrent extensive stage small cell lung cancer (ES-SCLC).
M. Baggstrom
,
R. Govindan
,
+5 authors
C. Erlichman
2010
Corpus ID: 74193480
e17523 Background: AT-101 is an oral inhibitor of the anti-apoptotic Bcl proteins (Bcl-2, Bcl-XL, Bcl-W, and Mcl-1) and potent…
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2004
2004
Cytotoxicity of enantiomers of gossypol Schiff's bases and optical stability of gossypolone.
Vithuy Dao
,
M. Dowd
,
Marie-Thérèse Martin
,
C. Gaspard
,
M. Mayer
,
R. Michelot
European journal of medicinal chemistry
2004
Corpus ID: 1677305
2000
2000
Chiral separation of the enantiomers of metoprolol and its metabolites by high performance liquid chromatography
K. Kim
,
Sang Duk Shin
,
+5 authors
Hyun Ju Kim
Archives of pharmacal research
2000
Corpus ID: 41855067
Abstract(1′R, 2R)-, (1′R, 2S)-, (1′S, 2R)- and (1′S, 2S)-α-hydroxymetoprolol; (2R)- and (2S)-O-desmethylmetoprolol; and (2R)- and…
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