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R-(-)-Gossypol Acetic Acid
Known as:
(-)-Gossypol Acetic Acid
, (2,2'-Binaphthalene)-8,8'-dicarboxaldehyde, 1,1',6,6',7,7'-hexahydroxy-3,3'-dimethyl-(R)-5,5'-bis(1-methylethyl)-, (2R)-, compd. with acetic acid (1:1)
, GOSSYPOL ACETIC ACID, (R)-
The orally bioavailable solvate of the R-(-) enantiomer of gossypol and acetic acid with potential antineoplastic activity. As a BH3 mimetic, R…
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National Institutes of Health
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gossypol acetic acid
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2010
2010
Phase II trial of R-(-)-gossypol acetic acid (NSC 726190, AT-101) in patients with recurrent extensive stage small cell lung cancer (ES-SCLC).
M. Baggstrom
,
R. Govindan
,
+5 authors
C. Erlichman
2010
Corpus ID: 74193480
e17523 Background: AT-101 is an oral inhibitor of the anti-apoptotic Bcl proteins (Bcl-2, Bcl-XL, Bcl-W, and Mcl-1) and potent…
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