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R-(-)-Gossypol Acetic Acid

Known as: (-)-Gossypol Acetic Acid, (2,2'-Binaphthalene)-8,8'-dicarboxaldehyde, 1,1',6,6',7,7'-hexahydroxy-3,3'-dimethyl-(R)-5,5'-bis(1-methylethyl)-, (2R)-, compd. with acetic acid (1:1), GOSSYPOL ACETIC ACID, (R)- 
The orally bioavailable solvate of the R-(-) enantiomer of gossypol and acetic acid with potential antineoplastic activity. As a BH3 mimetic, R… 
National Institutes of Health

Papers overview

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2011
2011
The natural BH3-mimetic (−)-gossypol shows promising efficacy in ongoing phase II/III clinical trials for human prostate cancer… 
2010
2010
Prostate cancer remains a leading cause of cancer death in American men. Androgen deprivation therapy (ADT) is the most common… 
2009
2009
e13502 Background: AT-101 [R-(-)-gossypol acetic acid] (AT) is an orally-administered BH3 mimetic that lowers the threshold for… 
2008
2008
Two pairs of diastereoisomeric acetylenic norlignan compounds with PhCH(OR1)CH(OR2)CH2C≡CPh skeleta: (1R, 2R)-1-O… 
2007
2007
PURPOSE Upregulation of Bcl-2 family members is a well-established mechanism in the development of androgen-independent prostate… 
2002
2002
Gossypol is an antifertilizing agent in males and females. However, gossypol and its metabolite, gossypolone, have also gained… 
2000
2000
Abstract(1′R, 2R)-, (1′R, 2S)-, (1′S, 2R)- and (1′S, 2S)-α-hydroxymetoprolol; (2R)- and (2S)-O-desmethylmetoprolol; and (2R)- and…