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R-(-)-Gossypol Acetic Acid

Known as: (-)-Gossypol Acetic Acid, (2,2'-Binaphthalene)-8,8'-dicarboxaldehyde, 1,1',6,6',7,7'-hexahydroxy-3,3'-dimethyl-(R)-5,5'-bis(1-methylethyl)-, (2R)-, compd. with acetic acid (1:1), GOSSYPOL ACETIC ACID, (R)- 
The orally bioavailable solvate of the R-(-) enantiomer of gossypol and acetic acid with potential antineoplastic activity. As a BH3 mimetic, R… Expand
National Institutes of Health

Papers overview

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2015
2015
There is an error in Fig 1. In Fig 1C, the y-axis should read: “Percentage of ethidium homodimer-1 positive dead cells.” Please… Expand
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2014
2014
Natural BH3-memitic (-)-gossypol shows promising antitumor efficacy in several kinds of cancer. However, our previous studies… Expand
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2012
2012
R-(-)-gossypol acetic acid (AT-101), a natural BH3 mimetic, is investigated in a Phase I/II clinical trial for the treatment of… Expand
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2011
2011
The natural BH3-mimetic (−)-gossypol shows promising efficacy in ongoing phase II/III clinical trials for human prostate cancer… Expand
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2010
2010
Bcl-2 is a key dual regulator of autophagy and apoptosis, but how the level of Bcl-2 influences the cellular decision between… Expand
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2010
2010
Prostate cancer remains a leading cause of cancer death in American men. Androgen deprivation therapy (ADT) is the most common… Expand
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2009
2009
e13502 Background: AT-101 [R-(-)-gossypol acetic acid] (AT) is an orally-administered BH3 mimetic that lowers the threshold for… Expand
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2007
2007
PURPOSE Upregulation of Bcl-2 family members is a well-established mechanism in the development of androgen-independent prostate… Expand
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2004
2004
Optical Schiff's bases of gossypol were prepared with chiral gossypol and ethylamine. As has been similarly observed among the… Expand
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2002
2002
Gossypol is an antifertilizing agent in males and females. However, gossypol and its metabolite, gossypolone, have also gained… Expand
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